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KPNA6 (karyopherin subunit alpha 6)

Identity

Alias_nameskaryopherin alpha 6 (importin alpha 7)
karyopherin alpha 6
Alias_symbol (synonym)IPOA7
KPNA7
MGC17918
FLJ11249
Other alias
HGNC (Hugo) KPNA6
LocusID (NCBI) 23633
Atlas_Id 78551
Location 1p35.2  [Link to chromosome band 1p35]
Location_base_pair Starts at 32108043 and ends at 32176567 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EXOSC10 (1p36.22) / KPNA6 (1p35.1)HDAC1 (1p35.1) / KPNA6 (1p35.1)KPNA6 (1p35.1) / KHDRBS1 (1p35.1)
KPNA6 (1p35.1) / KPNA6 (1p35.1)KPNA6 (1p35.1) / RHCE (1p36.11)KPNA6 (1p35.1) / SUGP2 (19p13.11)
PDGFRB (5q32) / KPNA6 (1p35.1)RLF (1p34.2) / KPNA6 (1p35.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KPNA6   6399
Cards
Entrez_Gene (NCBI)KPNA6  23633  karyopherin subunit alpha 6
AliasesIPOA7; KPNA7
GeneCards (Weizmann)KPNA6
Ensembl hg19 (Hinxton)ENSG00000025800 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000025800 [Gene_View]  chr1:32108043-32176567 [Contig_View]  KPNA6 [Vega]
ICGC DataPortalENSG00000025800
TCGA cBioPortalKPNA6
AceView (NCBI)KPNA6
Genatlas (Paris)KPNA6
WikiGenes23633
SOURCE (Princeton)KPNA6
Genetics Home Reference (NIH)KPNA6
Genomic and cartography
GoldenPath hg38 (UCSC)KPNA6  -     chr1:32108043-32176567 +  1p35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KPNA6  -     1p35.2   [Description]    (hg19-Feb_2009)
EnsemblKPNA6 - 1p35.2 [CytoView hg19]  KPNA6 - 1p35.2 [CytoView hg38]
Mapping of homologs : NCBIKPNA6 [Mapview hg19]  KPNA6 [Mapview hg38]
OMIM610563   
Gene and transcription
Genbank (Entrez)AB621806 AF060543 AK000724 AK002111 AK128609
RefSeq transcript (Entrez)NM_012316
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KPNA6
Cluster EST : UnigeneHs.711019 [ NCBI ]
CGAP (NCI)Hs.711019
Alternative Splicing GalleryENSG00000025800
Gene ExpressionKPNA6 [ NCBI-GEO ]   KPNA6 [ EBI - ARRAY_EXPRESS ]   KPNA6 [ SEEK ]   KPNA6 [ MEM ]
Gene Expression Viewer (FireBrowse)KPNA6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23633
GTEX Portal (Tissue expression)KPNA6
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60684   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60684  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60684
Splice isoforms : SwissVarO60684
PhosPhoSitePlusO60684
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Arm_3    Armadillo    Importin-a_IBB    Importing_su_alpha   
Domain families : Pfam (Sanger)Arm (PF00514)    Arm_3 (PF16186)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam16186    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)KPNA6
DMDM Disease mutations23633
Blocks (Seattle)KPNA6
PDB (SRS)4UAD   
PDB (PDBSum)4UAD   
PDB (IMB)4UAD   
PDB (RSDB)4UAD   
Structural Biology KnowledgeBase4UAD   
SCOP (Structural Classification of Proteins)4UAD   
CATH (Classification of proteins structures)4UAD   
SuperfamilyO60684
Human Protein AtlasENSG00000025800
Peptide AtlasO60684
HPRD09465
IPIIPI01015268   IPI00747764   IPI00514894   IPI01012685   
Protein Interaction databases
DIP (DOE-UCLA)O60684
IntAct (EBI)O60684
FunCoupENSG00000025800
BioGRIDKPNA6
STRING (EMBL)KPNA6
ZODIACKPNA6
Ontologies - Pathways
QuickGOO60684
Ontology : AmiGOprotein binding  nuclear pore  nucleoplasm  cytosol  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  membrane  positive regulation of transcription from RNA polymerase II promoter  maternal process involved in female pregnancy  
Ontology : EGO-EBIprotein binding  nuclear pore  nucleoplasm  cytosol  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  membrane  positive regulation of transcription from RNA polymerase II promoter  maternal process involved in female pregnancy  
NDEx NetworkKPNA6
Atlas of Cancer Signalling NetworkKPNA6
Wikipedia pathwaysKPNA6
Orthology - Evolution
OrthoDB23633
GeneTree (enSembl)ENSG00000025800
Phylogenetic Trees/Animal Genes : TreeFamKPNA6
HOVERGENO60684
HOGENOMO60684
Homologs : HomoloGeneKPNA6
Homology/Alignments : Family Browser (UCSC)KPNA6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKPNA6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KPNA6
dbVarKPNA6
ClinVarKPNA6
1000_GenomesKPNA6 
Exome Variant ServerKPNA6
ExAC (Exome Aggregation Consortium)KPNA6 (select the gene name)
Genetic variants : HAPMAP23633
Genomic Variants (DGV)KPNA6 [DGVbeta]
DECIPHERKPNA6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKPNA6 
Mutations
ICGC Data PortalKPNA6 
TCGA Data PortalKPNA6 
Broad Tumor PortalKPNA6
OASIS PortalKPNA6 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDKPNA6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KPNA6
DgiDB (Drug Gene Interaction Database)KPNA6
DoCM (Curated mutations)KPNA6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KPNA6 (select a term)
intoGenKPNA6
Cancer3DKPNA6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610563   
Orphanet
MedgenKPNA6
Genetic Testing Registry KPNA6
NextProtO60684 [Medical]
TSGene23633
GENETestsKPNA6
Target ValidationKPNA6
Huge Navigator KPNA6 [HugePedia]
snp3D : Map Gene to Disease23633
BioCentury BCIQKPNA6
ClinGenKPNA6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23633
Chemical/Pharm GKB GenePA30190
Clinical trialKPNA6
Miscellaneous
canSAR (ICR)KPNA6 (select the gene name)
Probes
Litterature
PubMed89 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKPNA6
EVEXKPNA6
GoPubMedKPNA6
iHOPKPNA6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:54:52 CEST 2017

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