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KPNA6 (karyopherin subunit alpha 6)

Identity

Alias (NCBI)IPOA7
HGNC (Hugo) KPNA6
HGNC Alias symbIPOA7
KPNA7
MGC17918
FLJ11249
HGNC Alias nameimportin alpha 7
HGNC Previous namekaryopherin alpha 6 (importin alpha 7)
 karyopherin alpha 6
LocusID (NCBI) 23633
Atlas_Id 78551
Location 1p35.2  [Link to chromosome band 1p35]
Location_base_pair Starts at 32108056 and ends at 32176563 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EXOSC10 (1p36.22)::KPNA6 (1p35.1)HDAC1 (1p35.1)::KPNA6 (1p35.1)KPNA6 (1p35.1)::KHDRBS1 (1p35.1)
KPNA6 (1p35.1)::KPNA6 (1p35.1)KPNA6 (1p35.1)::RHCE (1p36.11)KPNA6 (1p35.1)::SUGP2 (19p13.11)
PDGFRB (5q32)::KPNA6 (1p35.1)RLF (1p34.2)::KPNA6 (1p35.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KPNA6   6399
Cards
Entrez_Gene (NCBI)KPNA6    karyopherin subunit alpha 6
AliasesIPOA7
GeneCards (Weizmann)KPNA6
Ensembl hg19 (Hinxton)ENSG00000025800 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000025800 [Gene_View]  ENSG00000025800 [Sequence]  chr1:32108056-32176563 [Contig_View]  KPNA6 [Vega]
ICGC DataPortalENSG00000025800
TCGA cBioPortalKPNA6
AceView (NCBI)KPNA6
Genatlas (Paris)KPNA6
SOURCE (Princeton)KPNA6
Genetics Home Reference (NIH)KPNA6
Genomic and cartography
GoldenPath hg38 (UCSC)KPNA6  -     chr1:32108056-32176563 +  1p35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KPNA6  -     1p35.2   [Description]    (hg19-Feb_2009)
GoldenPathKPNA6 - 1p35.2 [CytoView hg19]  KPNA6 - 1p35.2 [CytoView hg38]
ImmunoBaseENSG00000025800
Genome Data Viewer NCBIKPNA6 [Mapview hg19]  
OMIM610563   
Gene and transcription
Genbank (Entrez)AB621806 AF060543 AK000724 AK002111 AK128609
RefSeq transcript (Entrez)NM_012316
Consensus coding sequences : CCDS (NCBI)KPNA6
Gene ExpressionKPNA6 [ NCBI-GEO ]   KPNA6 [ EBI - ARRAY_EXPRESS ]   KPNA6 [ SEEK ]   KPNA6 [ MEM ]
Gene Expression Viewer (FireBrowse)KPNA6 [ Firebrowse - Broad ]
GenevisibleExpression of KPNA6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23633
GTEX Portal (Tissue expression)KPNA6
Human Protein AtlasENSG00000025800-KPNA6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60684   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60684  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60684
PhosPhoSitePlusO60684
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Arm_3    Armadillo    Importin-a_IBB    Importin-a_IBB_sf    Importin_alpha   
Domain families : Pfam (Sanger)Arm (PF00514)    Arm_3 (PF16186)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam16186    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)KPNA6
PDB (RSDB)4UAD   
PDB Europe4UAD   
PDB (PDBSum)4UAD   
PDB (IMB)4UAD   
Structural Biology KnowledgeBase4UAD   
SCOP (Structural Classification of Proteins)4UAD   
CATH (Classification of proteins structures)4UAD   
SuperfamilyO60684
AlphaFold pdb e-kbO60684   
Human Protein Atlas [tissue]ENSG00000025800-KPNA6 [tissue]
HPRD09465
Protein Interaction databases
DIP (DOE-UCLA)O60684
IntAct (EBI)O60684
BioGRIDKPNA6
STRING (EMBL)KPNA6
ZODIACKPNA6
Ontologies - Pathways
QuickGOO60684
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytoplasm  NLS-bearing protein import into nucleus  nuclear localization sequence binding  membrane  viral genome replication  mitigation of host defenses by symbiont  host cell  positive regulation of transcription by RNA polymerase II  maternal process involved in female pregnancy  nuclear import signal receptor activity  entry of viral genome into host nucleus through nuclear pore complex via importin  positive regulation of cytokine production involved in inflammatory response  positive regulation of viral life cycle  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytoplasm  NLS-bearing protein import into nucleus  nuclear localization sequence binding  membrane  viral genome replication  mitigation of host defenses by symbiont  host cell  positive regulation of transcription by RNA polymerase II  maternal process involved in female pregnancy  nuclear import signal receptor activity  entry of viral genome into host nucleus through nuclear pore complex via importin  positive regulation of cytokine production involved in inflammatory response  positive regulation of viral life cycle  
NDEx NetworkKPNA6
Atlas of Cancer Signalling NetworkKPNA6
Wikipedia pathwaysKPNA6
Orthology - Evolution
OrthoDB23633
GeneTree (enSembl)ENSG00000025800
Phylogenetic Trees/Animal Genes : TreeFamKPNA6
Homologs : HomoloGeneKPNA6
Homology/Alignments : Family Browser (UCSC)KPNA6
Gene fusions - Rearrangements
Fusion : QuiverKPNA6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKPNA6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KPNA6
dbVarKPNA6
ClinVarKPNA6
MonarchKPNA6
1000_GenomesKPNA6 
Exome Variant ServerKPNA6
GNOMAD BrowserENSG00000025800
Varsome BrowserKPNA6
ACMGKPNA6 variants
VarityO60684
Genomic Variants (DGV)KPNA6 [DGVbeta]
DECIPHERKPNA6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKPNA6 
Mutations
ICGC Data PortalKPNA6 
TCGA Data PortalKPNA6 
Broad Tumor PortalKPNA6
OASIS PortalKPNA6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKPNA6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKPNA6
Mutations and Diseases : HGMDKPNA6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKPNA6
DgiDB (Drug Gene Interaction Database)KPNA6
DoCM (Curated mutations)KPNA6
CIViC (Clinical Interpretations of Variants in Cancer)KPNA6
Cancer3DKPNA6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610563   
Orphanet
DisGeNETKPNA6
MedgenKPNA6
Genetic Testing Registry KPNA6
NextProtO60684 [Medical]
GENETestsKPNA6
Target ValidationKPNA6
Huge Navigator KPNA6 [HugePedia]
ClinGenKPNA6
Clinical trials, drugs, therapy
MyCancerGenomeKPNA6
Protein Interactions : CTDKPNA6
Pharm GKB GenePA30190
PharosO60684
Clinical trialKPNA6
Miscellaneous
canSAR (ICR)KPNA6
HarmonizomeKPNA6
ARCHS4KPNA6
DataMed IndexKPNA6
Probes
Litterature
PubMed136 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKPNA6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:23:55 CET 2022

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