Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

KRAS (Kirsten rat sarcoma 2 viral oncogene homolog)

Written1999-02Franz Watzinger, Thomas Lion
Children's Cancer Research Institute (CCRI), Kinderspitalgasse 6, A-1090 Vienna, Austria

(Note : for Links provided by Atlas : click)

Identity

Other namesC-K-RAS
CFC2
K-RAS2A
K-RAS2B
K-RAS4A
K-RAS4B
KI-RAS
KRAS1
KRAS2
NS
NS3
RALD
RASK2
HGNC (Hugo) KRAS
LocusID (NCBI) 3845
Atlas_Id 91
Location 12p12.1
Location_base_pair Starts at 25357723 and ends at 25403865 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Fusion genes
(updated 2016)
CDC42SE1 (1q21.3) / KRAS (12p12.1)KRAS (12p12.1) / CDH13 (16q23.3)KRAS (12p12.1) / KIAA0907 (1q22)
KRAS (12p12.1) / KMT2A (11q23.3)KRAS (12p12.1) / LMNTD1 (12p12.1)KRAS (12p12.1) / RERGL (12p12.3)
UBE2L3 (22q11.21) / KRAS (12p12.1)
Note more on the RAS family is available as a deep insight

DNA/RNA

 
  K-ras splicing variants alternative splicing of K-ras precursor mRNA leads to the two transcripts which differ by the ex- or inclusion of Exon 4a; Exons that encode protein are shown as black boxes, untranslated exons as white boxes; the upstream untranslated exon is indicated as Exon -1
Description consists of six exons, spread over 35kb of genomic DNA.
Transcription alternative RNA splicing reveals two different transcripts of 5.5 and 3.8kb (see Fig); if Exon 4a is skipped exon 4b is directly joined to exon 3; in 98% of the transcripts exon 4a is spliced out and only exon 4b is available for translation into protein.
Pseudogene c-Ki-ras 1, inactivated, processed pseudogene which is located on Chromosome 6

Protein

Description regular RAS protein - characterized in the RAS family page.
Expression ubiquitously expressed
Localisation anchored to the inner surface of the plasma membrane
Function analogously to other GTP-binding proteins (such as Translation Elongation Factor EFTu or signal transducing G-Proteins) RAS proteins are involved in signal transduction pathways
Homology ras gene family is part of the ras superfamily including the mammalian RAS, RAL, RAC, RHO, RAP, and RAB gene families and the yeast homologs like SEC4 and YPT1 genes; genes encode small monomeric proteins of low molecular mass (20-30 kDa) which share at least 30% homology to RAS proteins.

Implicated in

Note
Entity tumor (frequency of K-RAS mutations); references in Full Bibliography
  
Entity pancreas (80-90%)
  
Entity colon and rectum (25-60%)
  
Entity lung (25-60%)
  
Entity prostate (0-25%)
  
Entity skin (0-25%)
  
Entity thyroid (0-60%)
  
Entity liver (10-25%)
  
Entity ovary (0-50%)
  
Entity endometrium (10-40%)
  
Entity kidney (0-50%)
  
Entity brain (0-15%)
  
Entity testis (seminoma) (10-45%)
  
Entity acute non lymphocytic leukemia and myelodysplasia (5-15%)
  
Entity urinary bladder (5%)
  
Entity head and neck (10%)
  
Entity breast (10%)
  

Bibliography

Human cancer and cellular oncogenes.
Nishimura S, Sekiya T
The Biochemical journal. 1987 ; 243 (2) : 313-327.
PMID 3307760
 
ras oncogenes in human cancer: a review.
Bos JL
Cancer research. 1989 ; 49 (17) : 4682-4689.
PMID 2547513
 
ras oncogenes: their role in neoplasia.
Barbacid M
European journal of clinical investigation. 1990 ; 20 (3) : 225-235.
PMID 2114981
 
ras activation in experimental carcinogenesis.
Mangues R, Pellicer A
Seminars in cancer biology. 1992 ; 3 (4) : 229-239.
PMID 1421167
 

Citation

This paper should be referenced as such :
Watzinger, F ; Lion, T
KRAS (Kirsten rat sarcoma viral oncogene homolog)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(2):66-67.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/KRASID91.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 8 ]
  Classification of myelodysplastic syndromes 2015
Chronic Myelomonocytic Leukemia (CMML)
Juvenile Chronic Myelogenous Leukemia (JCML)
Acute basophilic leukemia;t(X;6)(p11;q23) MYB/GATA1
Plasma cell leukemia (PCL)
t(3;21)(q26;q22) RUNX1/MECOM
t(4;11)(q21;p15) NUP98/RAP1GDS1
t(4;11)(q23;p15) NUP98/RAP1GDS1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 25 ]
  Head and Neck: Odontogenic tumor: Ameloblastoma
Thyroid: Anaplastic (undifferentiated) carcinoma
Breast tumors : an overview
Neuro-Endocrine/Endocrine System: Carcinoid tumors
Colon: Colorectal adenocarcinoma
Bone: Dedifferentiated chondrosarcoma
Breast: Ductal carcinoma
Gallbladder: Carcinoma of the gallbladder and extrahepatic bile ducts
Head and Neck: Epidermoid carcinoma
Liver: Combined hepatocellular and cholangiocarcinoma
Gallbladder: Intrahepatic cholangiocarcinoma
Lung: Non-small cell carcinoma with inv(2)(p21p23) EML4/ALK
Liver tumors: an overview
Lung: Non-small cell carcinoma
Lung tumors: an overview
Thyroid: Medullary carcinoma
Ovary: Germ cell tumors
Ovarian tumours : an overview
Ovary: Sex cord-stromal tumors
Ovary: Epithelial tumors
Pancreatic tumors: an overview
Skin: Melanoma
Lung: Adenocarcinoma with t(6;12)(q22;q14.1) LRIG3/ROS1
Lung: Translocations in Adenocarcinoma
Lung: Translocations in Squamous Cell Carcinoma
Uterus Tumours: an Overview

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Noonan syndrome

External links

Nomenclature
HGNC (Hugo)KRAS   6407
Cards
AtlasKRASID91
Entrez_Gene (NCBI)KRAS  3845  Kirsten rat sarcoma viral oncogene homolog
GeneCards (Weizmann)KRAS
Ensembl hg19 (Hinxton)ENSG00000133703 [Gene_View]  chr12:25357723-25403865 [Contig_View]  KRAS [Vega]
Ensembl hg38 (Hinxton)ENSG00000133703 [Gene_View]  chr12:25357723-25403865 [Contig_View]  KRAS [Vega]
ICGC DataPortalENSG00000133703
TCGA cBioPortalKRAS
AceView (NCBI)KRAS
Genatlas (Paris)KRAS
WikiGenes3845
SOURCE (Princeton)KRAS
Genomic and cartography
GoldenPath hg19 (UCSC)KRAS  -     chr12:25357723-25403865 -  12p12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KRAS  -     12p12.1   [Description]    (hg38-Dec_2013)
EnsemblKRAS - 12p12.1 [CytoView hg19]  KRAS - 12p12.1 [CytoView hg38]
Mapping of homologs : NCBIKRAS [Mapview hg19]  KRAS [Mapview hg38]
OMIM109800   114480   137215   163200   190070   211980   260350   601626   609942   615278   
Gene and transcription
Genbank (Entrez)AA812162 AF493917 AI539465 AK292510 AW117295
RefSeq transcript (Entrez)NM_004985 NM_033360
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_007524 NT_009714 NW_004929383
Consensus coding sequences : CCDS (NCBI)KRAS
Cluster EST : UnigeneHs.505033 [ NCBI ]
CGAP (NCI)Hs.505033
Alternative Splicing GalleryENSG00000133703
Gene ExpressionKRAS [ NCBI-GEO ]   KRAS [ EBI - ARRAY_EXPRESS ]   KRAS [ SEEK ]   KRAS [ MEM ]
Gene Expression Viewer (FireBrowse)KRAS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)3845
GTEX Portal (Tissue expression)KRAS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01116 (Uniprot)
NextProtP01116  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01116
Splice isoforms : SwissVarP01116 (Swissvar)
PhosPhoSitePlusP01116
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAS (SM00173)  
DMDM Disease mutations3845
Blocks (Seattle)KRAS
PDB (SRS)1D8D    1D8E    1KZO    1KZP    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E   
PDB (PDBSum)1D8D    1D8E    1KZO    1KZP    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E   
PDB (IMB)1D8D    1D8E    1KZO    1KZP    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E   
PDB (RSDB)1D8D    1D8E    1KZO    1KZP    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E   
Structural Biology KnowledgeBase1D8D    1D8E    1KZO    1KZP    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E   
SCOP (Structural Classification of Proteins)1D8D    1D8E    1KZO    1KZP    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E   
CATH (Classification of proteins structures)1D8D    1D8E    1KZO    1KZP    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E   
SuperfamilyP01116
Human Protein AtlasENSG00000133703
Peptide AtlasP01116
HPRD01817
IPIIPI00423568   IPI00423570   IPI01026223   IPI01026118   
Protein Interaction databases
DIP (DOE-UCLA)P01116
IntAct (EBI)P01116
FunCoupENSG00000133703
BioGRIDKRAS
STRING (EMBL)KRAS
ZODIACKRAS
Ontologies - Pathways
QuickGOP01116
Ontology : AmiGOMAPK cascade  positive regulation of protein phosphorylation  stimulatory C-type lectin receptor signaling pathway  GTPase activity  protein binding  GTP binding  cytoplasm  mitochondrion  cytosol  plasma membrane  focal adhesion  intracellular protein transport  nucleocytoplasmic transport  epidermal growth factor receptor signaling pathway  Ras protein signal transduction  axon guidance  positive regulation of cell proliferation  visual learning  positive regulation of gene expression  membrane  GMP binding  GDP binding  cytokine-mediated signaling pathway  forebrain astrocyte development  actin cytoskeleton organization  LRR domain binding  extrinsic component of cytoplasmic side of plasma membrane  regulation of protein stability  regulation of synaptic transmission, GABAergic  protein complex binding  positive regulation of Rac protein signal transduction  social behavior  endocrine signaling  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  positive regulation of MAP kinase activity  negative regulation of neuron apoptotic process  membrane raft  negative regulation of cell differentiation  regulation of long-term neuronal synaptic plasticity  homeostasis of number of cells within a tissue  leukocyte migration  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  striated muscle cell differentiation  response to glucocorticoid  response to mineralocorticoid  epithelial tube branching involved in lung morphogenesis  
Ontology : EGO-EBIMAPK cascade  positive regulation of protein phosphorylation  stimulatory C-type lectin receptor signaling pathway  GTPase activity  protein binding  GTP binding  cytoplasm  mitochondrion  cytosol  plasma membrane  focal adhesion  intracellular protein transport  nucleocytoplasmic transport  epidermal growth factor receptor signaling pathway  Ras protein signal transduction  axon guidance  positive regulation of cell proliferation  visual learning  positive regulation of gene expression  membrane  GMP binding  GDP binding  cytokine-mediated signaling pathway  forebrain astrocyte development  actin cytoskeleton organization  LRR domain binding  extrinsic component of cytoplasmic side of plasma membrane  regulation of protein stability  regulation of synaptic transmission, GABAergic  protein complex binding  positive regulation of Rac protein signal transduction  social behavior  endocrine signaling  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  positive regulation of MAP kinase activity  negative regulation of neuron apoptotic process  membrane raft  negative regulation of cell differentiation  regulation of long-term neuronal synaptic plasticity  homeostasis of number of cells within a tissue  leukocyte migration  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  striated muscle cell differentiation  response to glucocorticoid  response to mineralocorticoid  epithelial tube branching involved in lung morphogenesis  
Pathways : BIOCARTATelomeres, Telomerase, Cellular Aging, and Immortality [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    FoxO signaling pathway    PI3K-Akt signaling pathway    Dorso-ventral axis formation    Axon guidance    VEGF signaling pathway    Tight junction    Gap junction    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Long-term potentiation    Neurotrophin signaling pathway    Cholinergic synapse    Serotonergic synapse    Long-term depression    Regulation of actin cytoskeleton    Insulin signaling pathway    GnRH signaling pathway    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Prolactin signaling pathway    Thyroid hormone signaling pathway    Aldosterone-regulated sodium reabsorption    Alcoholism    Hepatitis C    Hepatitis B    HTLV-I infection    Pathways in cancer    Viral carcinogenesis    Proteoglycans in cancer    MicroRNAs in cancer    Colorectal cancer    Renal cell carcinoma    Pancreatic cancer    Endometrial cancer    Glioma    Prostate cancer    Thyroid cancer    Melanoma    Bladder cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Non-small cell lung cancer   
REACTOMEP01116 [protein]
REACTOME PathwaysR-HSA-5654693 FRS-mediated FGFR1 signaling [pathway]
REACTOME PathwaysR-HSA-5655253 Signaling by FGFR2 in disease [pathway]
REACTOME PathwaysR-HSA-5654699 SHC-mediated cascade:FGFR2 [pathway]
REACTOME PathwaysR-HSA-2871796 FCERI mediated MAPK activation [pathway]
REACTOME PathwaysR-HSA-5675221 Negative regulation of MAPK pathway [pathway]
REACTOME PathwaysR-HSA-1250196 SHC1 events in ERBB2 signaling [pathway]
REACTOME PathwaysR-HSA-1433557 Signaling by SCF-KIT [pathway]
REACTOME PathwaysR-HSA-2424491 DAP12 signaling [pathway]
REACTOME PathwaysR-HSA-5654706 FRS-mediated FGFR3 signaling [pathway]
REACTOME PathwaysR-HSA-2179392 EGFR Transactivation by Gastrin [pathway]
REACTOME PathwaysR-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [pathway]
REACTOME PathwaysR-HSA-1963640 GRB2 events in ERBB2 signaling [pathway]
REACTOME PathwaysR-HSA-5218921 VEGFR2 mediated cell proliferation [pathway]
REACTOME PathwaysR-HSA-5673000 RAF activation [pathway]
REACTOME PathwaysR-HSA-171007 p38MAPK events [pathway]
REACTOME PathwaysR-HSA-5654700 FRS-mediated FGFR2 signaling [pathway]
REACTOME PathwaysR-HSA-375165 NCAM signaling for neurite out-growth [pathway]
REACTOME PathwaysR-HSA-112412 SOS-mediated signalling [pathway]
REACTOME PathwaysR-HSA-5658442 Regulation of RAS by GAPs [pathway]
REACTOME PathwaysR-HSA-5654704 SHC-mediated cascade:FGFR3 [pathway]
REACTOME PathwaysR-HSA-5655332 Signaling by FGFR3 in disease [pathway]
REACTOME PathwaysR-HSA-74751 Insulin receptor signalling cascade [pathway]
REACTOME PathwaysR-HSA-5674135 MAP2K and MAPK activation [pathway]
REACTOME PathwaysR-HSA-112412 SOS-mediated signalling [pathway]
REACTOME PathwaysR-HSA-5673001 RAF/MAP kinase cascade [pathway]
REACTOME PathwaysR-HSA-2428933 SHC-related events triggered by IGF1R [pathway]
REACTOME PathwaysR-HSA-179812 GRB2 events in EGFR signaling [pathway]
REACTOME PathwaysR-HSA-5655291 Signaling by FGFR4 in disease [pathway]
REACTOME PathwaysR-HSA-5654688 SHC-mediated cascade:FGFR1 [pathway]
REACTOME PathwaysR-HSA-210993 Tie2 Signaling [pathway]
REACTOME PathwaysR-HSA-5655302 Signaling by FGFR1 in disease [pathway]
REACTOME PathwaysR-HSA-180336 SHC1 events in EGFR signaling [pathway]
REACTOME PathwaysR-HSA-1250347 SHC1 events in ERBB4 signaling [pathway]
REACTOME PathwaysR-HSA-1169092 Activation of RAS in B cells [pathway]
REACTOME PathwaysR-HSA-167044 Signalling to RAS [pathway]
REACTOME PathwaysR-HSA-186763 Downstream signal transduction [pathway]
REACTOME PathwaysR-HSA-5654719 SHC-mediated cascade:FGFR4 [pathway]
REACTOME PathwaysR-HSA-5637810 Constitutive Signaling by EGFRvIII [pathway]
REACTOME PathwaysR-HSA-5654712 FRS-mediated FGFR4 signaling [pathway]
REACTOME PathwaysR-HSA-5621575 CD209 (DC-SIGN) signaling [pathway]
NDEx Network
Atlas of Cancer Signalling NetworkKRAS
Wikipedia pathwaysKRAS
Orthology - Evolution
OrthoDB3845
GeneTree (enSembl)ENSG00000133703
Phylogenetic Trees/Animal Genes : TreeFamKRAS
Homologs : HomoloGeneKRAS
Homology/Alignments : Family Browser (UCSC)KRAS
Gene fusions - Rearrangements
Fusion : MitelmanKRAS/CDH13 [12p12.1/16q23.3]  
Fusion : MitelmanKRAS/LMNTD1 [12p12.1/12p12.1]  [t(12;12)(p12;p12)]  
Fusion : MitelmanKRAS/RERGL [12p12.1/12p12.3]  [t(12;12)(p12;p12)]  
Fusion : COSMICUBE2L3 [22q11.21]  -  KRAS [12p12.1]  [fusion_1298]  [fusion_1299]  
Fusion: TCGAKRAS 12p12.1 IFLTD1 OV
Fusion: TCGAKRAS 12p12.1 RERGL 12p12.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerKRAS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRAS
dbVarKRAS
ClinVarKRAS
1000_GenomesKRAS 
Exome Variant ServerKRAS
ExAC (Exome Aggregation Consortium)KRAS (select the gene name)
Genetic variants : HAPMAP3845
Genomic Variants (DGV)KRAS [DGVbeta]
Mutations
ICGC Data PortalKRAS 
TCGA Data PortalKRAS 
Broad Tumor PortalKRAS
OASIS PortalKRAS [ Somatic mutations - Copy number]
Cancer Gene: CensusKRAS 
Somatic Mutations in Cancer : COSMICKRAS 
intOGen PortalKRAS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch KRAS
DgiDB (Drug Gene Interaction Database)KRAS
DoCM (Curated mutations)KRAS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KRAS (select a term)
intoGenKRAS
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:25357723-25403865  ENSG00000133703
CONAN: Copy Number AnalysisKRAS 
Mutations and Diseases : HGMDKRAS
OMIM109800    114480    137215    163200    190070    211980    260350    601626    609942    615278   
MedgenKRAS
Genetic Testing Registry KRAS
NextProtP01116 [Medical]
TSGene3845
GENETestsKRAS
Huge Navigator KRAS [HugePedia]
snp3D : Map Gene to Disease3845
BioCentury BCIQKRAS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3845
Chemical/Pharm GKB GenePA30196
Drug Sensitivity KRAS
Clinical trialKRAS
Miscellaneous
canSAR (ICR)KRAS (select the gene name)
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=KRAS
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKRAS
GoPubMedKRAS
iHOPKRAS
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Apr 27 19:14:56 CEST 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.