Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KRT10 (keratin 10)

Identity

Alias (NCBI)BCIE
BIE
CK10
EHK
K10
KPP
HGNC (Hugo) KRT10
HGNC Alias symbK10
CK10
HGNC Alias namecytokeratin 10
 epidermolytic hyperkeratosis
HGNC Previous nameKPP
HGNC Previous namekeratosis palmaris et plantaris
 keratin 10, type I
LocusID (NCBI) 3858
Atlas_Id 45972
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 40818117 and ends at 40822614 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KRT10 (17q21.2) / ARFGEF2 (20q13.13)KRT10 (17q21.2) / KRT10 (17q21.2)TANC2 (17q23.2) / KRT10 (17q21.2)
KRT10 17q21.2 / ARFGEF2 20q13.13TANC2 17q23.2 / KRT10 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(17;17)(q21;q23) TANC2/KRT10
t(17;20)(q21;q13) KRT10/ARFGEF2


External links

Nomenclature
HGNC (Hugo)KRT10   6413
Cards
Entrez_Gene (NCBI)KRT10  3858  keratin 10
AliasesBCIE; BIE; CK10; EHK; 
K10; KPP
GeneCards (Weizmann)KRT10
Ensembl hg19 (Hinxton)ENSG00000186395 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186395 [Gene_View]  ENSG00000186395 [Sequence]  chr17:40818117-40822614 [Contig_View]  KRT10 [Vega]
ICGC DataPortalENSG00000186395
TCGA cBioPortalKRT10
AceView (NCBI)KRT10
Genatlas (Paris)KRT10
WikiGenes3858
SOURCE (Princeton)KRT10
Genetics Home Reference (NIH)KRT10
Genomic and cartography
GoldenPath hg38 (UCSC)KRT10  -     chr17:40818117-40822614 -  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KRT10  -     17q21.2   [Description]    (hg19-Feb_2009)
GoldenPathKRT10 - 17q21.2 [CytoView hg19]  KRT10 - 17q21.2 [CytoView hg38]
ImmunoBaseENSG00000186395
genome Data Viewer NCBIKRT10 [Mapview hg19]  
OMIM113800   148080   607602   609165   
Gene and transcription
Genbank (Entrez)BC034697 CU455823 J04029 M19156 M77663
RefSeq transcript (Entrez)NM_000421 NM_001379366
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KRT10
Alternative Splicing GalleryENSG00000186395
Gene ExpressionKRT10 [ NCBI-GEO ]   KRT10 [ EBI - ARRAY_EXPRESS ]   KRT10 [ SEEK ]   KRT10 [ MEM ]
Gene Expression Viewer (FireBrowse)KRT10 [ Firebrowse - Broad ]
GenevisibleExpression of KRT10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3858
GTEX Portal (Tissue expression)KRT10
Human Protein AtlasENSG00000186395-KRT10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13645   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13645  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13645
Splice isoforms : SwissVarP13645
PhosPhoSitePlusP13645
Domaine pattern : Prosite (Expaxy)IF_ROD_1 (PS00226)    IF_ROD_2 (PS51842)   
Domains : Interpro (EBI)IF_conserved    IF_rod_dom    IF_rod_dom_coil1B    Keratin_I   
Domain families : Pfam (Sanger)Filament (PF00038)   
Domain families : Pfam (NCBI)pfam00038   
Domain families : Smart (EMBL)Filament (SM01391)  
Conserved Domain (NCBI)KRT10
DMDM Disease mutations3858
Blocks (Seattle)KRT10
PDB (RSDB)3ASW    4F1Z    4ZRY    6E2J    6EC0    6UUI   
PDB Europe3ASW    4F1Z    4ZRY    6E2J    6EC0    6UUI   
PDB (PDBSum)3ASW    4F1Z    4ZRY    6E2J    6EC0    6UUI   
PDB (IMB)3ASW    4F1Z    4ZRY    6E2J    6EC0    6UUI   
Structural Biology KnowledgeBase3ASW    4F1Z    4ZRY    6E2J    6EC0    6UUI   
SCOP (Structural Classification of Proteins)3ASW    4F1Z    4ZRY    6E2J    6EC0    6UUI   
CATH (Classification of proteins structures)3ASW    4F1Z    4ZRY    6E2J    6EC0    6UUI   
SuperfamilyP13645
Human Protein Atlas [tissue]ENSG00000186395-KRT10 [tissue]
Peptide AtlasP13645
HPRD01021
IPIIPI00009865   
Protein Interaction databases
DIP (DOE-UCLA)P13645
IntAct (EBI)P13645
FunCoupENSG00000186395
BioGRIDKRT10
STRING (EMBL)KRT10
ZODIACKRT10
Ontologies - Pathways
QuickGOP13645
Ontology : AmiGOcornified envelope  protein binding  extracellular space  nucleus  cytoplasm  cytosol  intermediate filament  cell surface  membrane  peptide cross-linking  keratinocyte differentiation  structural constituent of epidermis  structural constituent of epidermis  keratinization  positive regulation of epidermis development  protein heterodimerization activity  protein heterotetramerization  extracellular exosome  cornification  
Ontology : EGO-EBIcornified envelope  protein binding  extracellular space  nucleus  cytoplasm  cytosol  intermediate filament  cell surface  membrane  peptide cross-linking  keratinocyte differentiation  structural constituent of epidermis  structural constituent of epidermis  keratinization  positive regulation of epidermis development  protein heterodimerization activity  protein heterotetramerization  extracellular exosome  cornification  
Pathways : KEGGStaphylococcus aureus infection   
NDEx NetworkKRT10
Atlas of Cancer Signalling NetworkKRT10
Wikipedia pathwaysKRT10
Orthology - Evolution
OrthoDB3858
GeneTree (enSembl)ENSG00000186395
Phylogenetic Trees/Animal Genes : TreeFamKRT10
HOGENOMP13645
Homologs : HomoloGeneKRT10
Homology/Alignments : Family Browser (UCSC)KRT10
Gene fusions - Rearrangements
Fusion : MitelmanKRT10/ARFGEF2 [17q21.2/20q13.13]  
Fusion : MitelmanTANC2/KRT10 [17q23.2/17q21.2]  
Fusion PortalKRT10 17q21.2 ARFGEF2 20q13.13 SKCM
Fusion PortalTANC2 17q23.2 KRT10 17q21.2 BRCA
Fusion : QuiverKRT10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKRT10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRT10
dbVarKRT10
ClinVarKRT10
MonarchKRT10
1000_GenomesKRT10 
Exome Variant ServerKRT10
GNOMAD BrowserENSG00000186395
Varsome BrowserKRT10
Genetic variants : HAPMAP3858
Genomic Variants (DGV)KRT10 [DGVbeta]
DECIPHERKRT10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKRT10 
Mutations
ICGC Data PortalKRT10 
TCGA Data PortalKRT10 
Broad Tumor PortalKRT10
OASIS PortalKRT10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKRT10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKRT10
Mutations and Diseases : HGMDKRT10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
BioMutasearch KRT10
DgiDB (Drug Gene Interaction Database)KRT10
DoCM (Curated mutations)KRT10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KRT10 (select a term)
intoGenKRT10
Cancer3DKRT10(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM113800    148080    607602    609165   
Orphanet2079    20532    20530   
DisGeNETKRT10
MedgenKRT10
Genetic Testing Registry KRT10
NextProtP13645 [Medical]
TSGene3858
GENETestsKRT10
Target ValidationKRT10
Huge Navigator KRT10 [HugePedia]
snp3D : Map Gene to Disease3858
BioCentury BCIQKRT10
ClinGenKRT10
Clinical trials, drugs, therapy
Protein Interactions : CTD3858
Pharm GKB GenePA30200
Clinical trialKRT10
Miscellaneous
canSAR (ICR)KRT10 (select the gene name)
HarmonizomeKRT10
DataMed IndexKRT10
Probes
Litterature
PubMed135 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKRT10
EVEXKRT10
GoPubMedKRT10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:17:15 CEST 2020

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