Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KRT17 (keratin 17)

Identity

Alias_namesPCHC1
keratin 17
Other alias39.1
CK-17
K17
PC
PC2
HGNC (Hugo) KRT17
LocusID (NCBI) 3872
Atlas_Id 46323
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 41619440 and ends at 41624630 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KRT17   6427
Cards
Entrez_Gene (NCBI)KRT17  3872  keratin 17
Aliases39.1; CK-17; K17; PC; 
PC2; PCHC1
GeneCards (Weizmann)KRT17
Ensembl hg19 (Hinxton)ENSG00000128422 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128422 [Gene_View]  chr17:41619440-41624630 [Contig_View]  KRT17 [Vega]
ICGC DataPortalENSG00000128422
TCGA cBioPortalKRT17
AceView (NCBI)KRT17
Genatlas (Paris)KRT17
WikiGenes3872
SOURCE (Princeton)KRT17
Genetics Home Reference (NIH)KRT17
Genomic and cartography
GoldenPath hg38 (UCSC)KRT17  -     chr17:41619440-41624630 -  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KRT17  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblKRT17 - 17q21.2 [CytoView hg19]  KRT17 - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIKRT17 [Mapview hg19]  KRT17 [Mapview hg38]
OMIM148069   167210   184500   
Gene and transcription
Genbank (Entrez)AK095342 AK304373 BC000159 BC011901 BC056421
RefSeq transcript (Entrez)NM_000422
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KRT17
Cluster EST : UnigeneHs.2785 [ NCBI ]
CGAP (NCI)Hs.2785
Alternative Splicing GalleryENSG00000128422
Gene ExpressionKRT17 [ NCBI-GEO ]   KRT17 [ EBI - ARRAY_EXPRESS ]   KRT17 [ SEEK ]   KRT17 [ MEM ]
Gene Expression Viewer (FireBrowse)KRT17 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3872
GTEX Portal (Tissue expression)KRT17
Human Protein AtlasENSG00000128422-KRT17 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04695   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04695  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04695
Splice isoforms : SwissVarQ04695
PhosPhoSitePlusQ04695
Domaine pattern : Prosite (Expaxy)IF (PS00226)   
Domains : Interpro (EBI)IF    Intermediate_filament_CS    Keratin_I    Prefoldin   
Domain families : Pfam (Sanger)Filament (PF00038)   
Domain families : Pfam (NCBI)pfam00038   
Domain families : Smart (EMBL)Filament (SM01391)  
Conserved Domain (NCBI)KRT17
DMDM Disease mutations3872
Blocks (Seattle)KRT17
SuperfamilyQ04695
Human Protein Atlas [tissue]ENSG00000128422-KRT17 [tissue]
Peptide AtlasQ04695
HPRD01019
IPIIPI00450768   
Protein Interaction databases
DIP (DOE-UCLA)Q04695
IntAct (EBI)Q04695
FunCoupENSG00000128422
BioGRIDKRT17
STRING (EMBL)KRT17
ZODIACKRT17
Ontologies - Pathways
QuickGOQ04695
Ontology : AmiGOstructural constituent of cytoskeleton  protein binding  cytosol  intermediate filament  signal transduction  epidermis development  positive regulation of cell growth  hair follicle morphogenesis  keratinization  MHC class II receptor activity  MHC class II protein binding  intermediate filament organization  intermediate filament cytoskeleton  positive regulation of translation  positive regulation of hair follicle development  extracellular exosome  cornification  cell periphery  
Ontology : EGO-EBIstructural constituent of cytoskeleton  protein binding  cytosol  intermediate filament  signal transduction  epidermis development  positive regulation of cell growth  hair follicle morphogenesis  keratinization  MHC class II receptor activity  MHC class II protein binding  intermediate filament organization  intermediate filament cytoskeleton  positive regulation of translation  positive regulation of hair follicle development  extracellular exosome  cornification  cell periphery  
NDEx NetworkKRT17
Atlas of Cancer Signalling NetworkKRT17
Wikipedia pathwaysKRT17
Orthology - Evolution
OrthoDB3872
GeneTree (enSembl)ENSG00000128422
Phylogenetic Trees/Animal Genes : TreeFamKRT17
HOVERGENQ04695
HOGENOMQ04695
Homologs : HomoloGeneKRT17
Homology/Alignments : Family Browser (UCSC)KRT17
Gene fusions - Rearrangements
Tumor Fusion PortalKRT17
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKRT17 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRT17
dbVarKRT17
ClinVarKRT17
1000_GenomesKRT17 
Exome Variant ServerKRT17
ExAC (Exome Aggregation Consortium)ENSG00000128422
GNOMAD BrowserENSG00000128422
Genetic variants : HAPMAP3872
Genomic Variants (DGV)KRT17 [DGVbeta]
DECIPHERKRT17 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKRT17 
Mutations
ICGC Data PortalKRT17 
TCGA Data PortalKRT17 
Broad Tumor PortalKRT17
OASIS PortalKRT17 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKRT17  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKRT17
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KRT17
DgiDB (Drug Gene Interaction Database)KRT17
DoCM (Curated mutations)KRT17 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KRT17 (select a term)
intoGenKRT17
Cancer3DKRT17(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM148069    167210    184500   
Orphanet2169    8656   
DisGeNETKRT17
MedgenKRT17
Genetic Testing Registry KRT17
NextProtQ04695 [Medical]
TSGene3872
GENETestsKRT17
Target ValidationKRT17
Huge Navigator KRT17 [HugePedia]
snp3D : Map Gene to Disease3872
BioCentury BCIQKRT17
ClinGenKRT17
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3872
Chemical/Pharm GKB GenePA30214
Clinical trialKRT17
Miscellaneous
canSAR (ICR)KRT17 (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKRT17
EVEXKRT17
GoPubMedKRT17
iHOPKRT17
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:19:19 CET 2017

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