Atlas of Genetics and Cytogenetics in Oncology and Haematology

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KRT18 (keratin 18)

Identity

Other namesCYK18
K18
HGNC (Hugo) KRT18
LocusID (NCBI) 3875
Location 12q13.13
Location_base_pair Starts at 53342843 and ends at 53346685 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)KRT18   6430
Cards
Entrez_Gene (NCBI)KRT18  3875  keratin 18
GeneCards (Weizmann)KRT18
Ensembl hg19 (Hinxton)ENSG00000111057 [Gene_View]  chr12:53342843-53346685 [Contig_View]  KRT18 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111057 [Gene_View]  chr12:53342843-53346685 [Contig_View]  KRT18 [Vega]
ICGC DataPortalENSG00000111057
cBioPortalKRT18
AceView (NCBI)KRT18
Genatlas (Paris)KRT18
WikiGenes3875
SOURCE (Princeton)KRT18
Genomic and cartography
GoldenPath hg19 (UCSC)KRT18  -     chr12:53342843-53346685 +  12q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KRT18  -     12q13.13   [Description]    (hg38-Dec_2013)
EnsemblKRT18 - 12q13.13 [CytoView hg19]  KRT18 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIKRT18 [Mapview hg19]  KRT18 [Mapview hg38]
OMIM148070   
Gene and transcription
Genbank (Entrez)AK129587 AK223093 AK308506 AK313988 AY762101
RefSeq transcript (Entrez)NM_000224 NM_199187
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_008351 NT_029419 NW_001838059 NW_004929384
Consensus coding sequences : CCDS (NCBI)KRT18
Cluster EST : UnigeneHs.406013 [ NCBI ]
CGAP (NCI)Hs.406013
Alternative Splicing : Fast-db (Paris)GSHG0006680
Alternative Splicing GalleryENSG00000111057
Gene ExpressionKRT18 [ NCBI-GEO ]     KRT18 [ SEEK ]   KRT18 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05783 (Uniprot)
NextProtP05783  [Medical]
With graphics : InterProP05783
Splice isoforms : SwissVarP05783 (Swissvar)
Domaine pattern : Prosite (Expaxy)IF (PS00226)   
Domains : Interpro (EBI)IF    Intermediate_filament_CS    Keratin-18    Keratin_I   
Related proteins : CluSTrP05783
Domain families : Pfam (Sanger)Filament (PF00038)   
Domain families : Pfam (NCBI)pfam00038   
DMDM Disease mutations3875
Blocks (Seattle)P05783
Human Protein AtlasENSG00000111057
Peptide AtlasP05783
HPRD01020
IPIIPI00554788   IPI00816245   IPI01022070   
Protein Interaction databases
DIP (DOE-UCLA)P05783
IntAct (EBI)P05783
FunCoupENSG00000111057
BioGRIDKRT18
IntegromeDBKRT18
STRING (EMBL)KRT18
Ontologies - Pathways
QuickGOP05783
Ontology : AmiGOstructural molecule activity  protein binding  nucleolus  cytoplasm  microtubule organizing center  intermediate filament  cell cycle  anatomical structure morphogenesis  viral process  tumor necrosis factor-mediated signaling pathway  centriolar satellite  Golgi to plasma membrane CFTR protein transport  negative regulation of apoptotic process  poly(A) RNA binding  keratin filament  intermediate filament cytoskeleton organization  perinuclear region of cytoplasm  extracellular vesicular exosome  scaffold protein binding  extrinsic apoptotic signaling pathway  hepatocyte apoptotic process  
Ontology : EGO-EBIstructural molecule activity  protein binding  nucleolus  cytoplasm  microtubule organizing center  intermediate filament  cell cycle  anatomical structure morphogenesis  viral process  tumor necrosis factor-mediated signaling pathway  centriolar satellite  Golgi to plasma membrane CFTR protein transport  negative regulation of apoptotic process  poly(A) RNA binding  keratin filament  intermediate filament cytoskeleton organization  perinuclear region of cytoplasm  extracellular vesicular exosome  scaffold protein binding  extrinsic apoptotic signaling pathway  hepatocyte apoptotic process  
Pathways : KEGGPathogenic Escherichia coli infection   
Protein Interaction DatabaseKRT18
DoCM (Curated mutations)KRT18
Wikipedia pathwaysKRT18
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerKRT18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRT18
dbVarKRT18
ClinVarKRT18
1000_GenomesKRT18 
Exome Variant ServerKRT18
SNP (GeneSNP Utah)KRT18
SNP : HGBaseKRT18
Genetic variants : HAPMAPKRT18
Genomic VariantsKRT18  KRT18 [DGVbeta]
Mutations
ICGC Data PortalENSG00000111057 
Somatic Mutations in Cancer : COSMICKRT18 
CONAN: Copy Number AnalysisKRT18 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:53342843-53346685
Mutations and Diseases : HGMDKRT18
OMIM148070   
MedgenKRT18
NextProtP05783 [Medical]
GENETestsKRT18
Disease Genetic AssociationKRT18
Huge Navigator KRT18 [HugePedia]  KRT18 [HugeCancerGEM]
snp3D : Map Gene to Disease3875
DGIdb (Drug Gene Interaction db)KRT18
General knowledge
Homologs : HomoloGeneKRT18
Homology/Alignments : Family Browser (UCSC)KRT18
Phylogenetic Trees/Animal Genes : TreeFamKRT18
Chemical/Protein Interactions : CTD3875
Chemical/Pharm GKB GenePA30217
Clinical trialKRT18
Cancer Resource (Charite)ENSG00000111057
Other databases
Probes
Litterature
PubMed195 Pubmed reference(s) in Entrez
CoreMineKRT18
GoPubMedKRT18
iHOPKRT18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:21:46 CET 2014
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