Atlas of Genetics and Cytogenetics in Oncology and Haematology

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KRT18 (keratin 18)

Identity

Other namesCK-18
CYK18
K18
HGNC (Hugo) KRT18
LocusID (NCBI) 3875
Atlas_Id 41104
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 53342843 and ends at 53346685 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)		EHMT2 (6p21.33) / KRT18 (12q13.13)KRT18 (12q13.13) / PLEC (8q24.3)SND1 (7q32.1) / KRT18 (12q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Head and Neck: Thymus: Thymoma: an overview

External links

Nomenclature
HGNC (Hugo)KRT18   6430
Cards
Entrez_Gene (NCBI)KRT18  3875  keratin 18
AliasesCK-18; CYK18; K18
GeneCards (Weizmann)KRT18
Ensembl hg19 (Hinxton)ENSG00000111057 [Gene_View]  chr12:53342843-53346685 [Contig_View]  KRT18 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111057 [Gene_View]  chr12:53342843-53346685 [Contig_View]  KRT18 [Vega]
ICGC DataPortalENSG00000111057
TCGA cBioPortalKRT18
AceView (NCBI)KRT18
Genatlas (Paris)KRT18
WikiGenes3875
SOURCE (Princeton)KRT18
Genomic and cartography
GoldenPath hg19 (UCSC)KRT18  -     chr12:53342843-53346685 +  12q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KRT18  -     12q13.13   [Description]    (hg38-Dec_2013)
EnsemblKRT18 - 12q13.13 [CytoView hg19]  KRT18 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIKRT18 [Mapview hg19]  KRT18 [Mapview hg38]
OMIM148070   
Gene and transcription
Genbank (Entrez)AK129587 AK223093 AK308506 AK313988 AY762101
RefSeq transcript (Entrez)NM_000224 NM_199187
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_008351 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)KRT18
Cluster EST : UnigeneHs.406013 [ NCBI ]
CGAP (NCI)Hs.406013
Alternative Splicing GalleryENSG00000111057
Gene ExpressionKRT18 [ NCBI-GEO ]   KRT18 [ EBI - ARRAY_EXPRESS ]   KRT18 [ SEEK ]   KRT18 [ MEM ]
Gene Expression Viewer (FireBrowse)KRT18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3875
GTEX Portal (Tissue expression)KRT18
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05783 (Uniprot)
NextProtP05783  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05783
Splice isoforms : SwissVarP05783 (Swissvar)
PhosPhoSitePlusP05783
Domaine pattern : Prosite (Expaxy)IF (PS00226)   
Domains : Interpro (EBI)IF    Intermediate_filament_CS    Keratin-18    Keratin_I   
Domain families : Pfam (Sanger)Filament (PF00038)   
Domain families : Pfam (NCBI)pfam00038   
DMDM Disease mutations3875
Blocks (Seattle)KRT18
SuperfamilyP05783
Human Protein AtlasENSG00000111057
Peptide AtlasP05783
HPRD01020
IPIIPI00554788   IPI00816245   IPI01022070   
Protein Interaction databases
DIP (DOE-UCLA)P05783
IntAct (EBI)P05783
FunCoupENSG00000111057
BioGRIDKRT18
STRING (EMBL)KRT18
ZODIACKRT18
Ontologies - Pathways
QuickGOP05783
Ontology : AmiGOstructural molecule activity  protein binding  nucleolus  cytoplasm  microtubule organizing center  intermediate filament  cell cycle  anatomical structure morphogenesis  viral process  tumor necrosis factor-mediated signaling pathway  centriolar satellite  Golgi to plasma membrane CFTR protein transport  negative regulation of apoptotic process  poly(A) RNA binding  keratin filament  intermediate filament cytoskeleton organization  perinuclear region of cytoplasm  extracellular exosome  cell periphery  scaffold protein binding  extrinsic apoptotic signaling pathway  hepatocyte apoptotic process  
Ontology : EGO-EBIstructural molecule activity  protein binding  nucleolus  cytoplasm  microtubule organizing center  intermediate filament  cell cycle  anatomical structure morphogenesis  viral process  tumor necrosis factor-mediated signaling pathway  centriolar satellite  Golgi to plasma membrane CFTR protein transport  negative regulation of apoptotic process  poly(A) RNA binding  keratin filament  intermediate filament cytoskeleton organization  perinuclear region of cytoplasm  extracellular exosome  cell periphery  scaffold protein binding  extrinsic apoptotic signaling pathway  hepatocyte apoptotic process  
Pathways : KEGGPathogenic Escherichia coli infection   
NDEx NetworkKRT18
Atlas of Cancer Signalling NetworkKRT18
Wikipedia pathwaysKRT18
Orthology - Evolution
OrthoDB3875
GeneTree (enSembl)ENSG00000111057
Phylogenetic Trees/Animal Genes : TreeFamKRT18
Homologs : HomoloGeneKRT18
Homology/Alignments : Family Browser (UCSC)KRT18
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerKRT18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRT18
dbVarKRT18
ClinVarKRT18
1000_GenomesKRT18 
Exome Variant ServerKRT18
ExAC (Exome Aggregation Consortium)KRT18 (select the gene name)
Genetic variants : HAPMAP3875
Genomic Variants (DGV)KRT18 [DGVbeta]
Mutations
ICGC Data PortalKRT18 
TCGA Data PortalKRT18 
Broad Tumor PortalKRT18
OASIS PortalKRT18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKRT18 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KRT18
DgiDB (Drug Gene Interaction Database)KRT18
DoCM (Curated mutations)KRT18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KRT18 (select a term)
intoGenKRT18
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:53342843-53346685  ENSG00000111057
CONAN: Copy Number AnalysisKRT18 
Mutations and Diseases : HGMDKRT18
OMIM148070   
MedgenKRT18
Genetic Testing Registry KRT18
NextProtP05783 [Medical]
TSGene3875
GENETestsKRT18
Huge Navigator KRT18 [HugePedia]
snp3D : Map Gene to Disease3875
BioCentury BCIQKRT18
ClinGenKRT18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3875
Chemical/Pharm GKB GenePA30217
Clinical trialKRT18
Miscellaneous
canSAR (ICR)KRT18 (select the gene name)
Probes
Litterature
PubMed216 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKRT18
EVEXKRT18
GoPubMedKRT18
iHOPKRT18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:56:57 CEST 2016
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