KRT18 (keratin 18)

2003-08-01  

Identity

HGNC
KRT18
LOCATION
12q13.13
LOCUSID
3875
ALIAS
CK-18,CYK18,K18
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3875
MIM: 148070
HGNC: 6430
Ensembl: ENSG00000111057

Variants:

dbSNP: 3875
ClinVar: 3875
TCGA: ENSG00000111057
COSMIC: KRT18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111057ENST00000388835P05783
ENSG00000111057ENST00000388835A0A024RAY2
ENSG00000111057ENST00000388837P05783
ENSG00000111057ENST00000388837A0A024RAY2
ENSG00000111057ENST00000550600F8VZY9

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pathogenic Escherichia coli infectionKEGGko05130
Pathogenic Escherichia coli infectionKEGGhsa05130
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
234499732013Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation.62
194478762009Nuclear factor-kappaB-mediated transforming growth factor-beta-induced expression of vimentin is an independent predictor of biochemical recurrence after radical prostatectomy.49
211458052011An apoptosis panel for nonalcoholic steatohepatitis diagnosis.48
151944212004Keratin 8/18 breakdown and reorganization during apoptosis.45
170347882006CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation.39
175455232007Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy.38
151026692004Down-regulated expression of cytokeratin 18 promotes progression of human breast cancer.34
127173812003Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury.33
205380002010Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.32
205380002010Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.32

Citation

Dessen P

KRT18 (keratin 18)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41104/krt18