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KRT19 (keratin 19)

Identity

Alias_nameskeratin 19
Alias_symbol (synonym)K19
CK19
K1CS
MGC15366
Other alias
HGNC (Hugo) KRT19
LocusID (NCBI) 3880
Atlas_Id 41105
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 41523617 and ends at 41528389 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CEBPZ (2p22.2) / KRT19 (17q21.2)HSPB1 (7q11.23) / KRT19 (17q21.2)KRT19 (17q21.2) / CAT (11p13)
KRT19 (17q21.2) / EXOSC10 (1p36.22)KRT19 (17q21.2) / KRT19 (17q21.2)KRT19 (17q21.2) / SLC47A1 (17p11.2)
KRT19 (17q21.2) / SPINT1 (15q15.1)L2HGDH (14q21.3) / KRT19 (17q21.2)NPTN (15q24.1) / KRT19 (17q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Liver: Fibrolamellar carcinoma
Liver: Nested stromal epithelial tumor
Head and Neck: Thymus: Thymoma: an overview


External links

Nomenclature
HGNC (Hugo)KRT19   6436
Cards
Entrez_Gene (NCBI)KRT19  3880  keratin 19
AliasesCK19; K19; K1CS
GeneCards (Weizmann)KRT19
Ensembl hg19 (Hinxton)ENSG00000171345 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171345 [Gene_View]  chr17:41523617-41528389 [Contig_View]  KRT19 [Vega]
ICGC DataPortalENSG00000171345
TCGA cBioPortalKRT19
AceView (NCBI)KRT19
Genatlas (Paris)KRT19
WikiGenes3880
SOURCE (Princeton)KRT19
Genetics Home Reference (NIH)KRT19
Genomic and cartography
GoldenPath hg38 (UCSC)KRT19  -     chr17:41523617-41528389 -  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KRT19  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblKRT19 - 17q21.2 [CytoView hg19]  KRT19 - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIKRT19 [Mapview hg19]  KRT19 [Mapview hg38]
OMIM148020   
Gene and transcription
Genbank (Entrez)AB041267 AB041268 AK313261 BC002539 BC007628
RefSeq transcript (Entrez)NM_002276
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KRT19
Cluster EST : UnigeneHs.654568 [ NCBI ]
CGAP (NCI)Hs.654568
Alternative Splicing GalleryENSG00000171345
Gene ExpressionKRT19 [ NCBI-GEO ]   KRT19 [ EBI - ARRAY_EXPRESS ]   KRT19 [ SEEK ]   KRT19 [ MEM ]
Gene Expression Viewer (FireBrowse)KRT19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3880
GTEX Portal (Tissue expression)KRT19
Human Protein AtlasENSG00000171345-KRT19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08727   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08727  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08727
Splice isoforms : SwissVarP08727
PhosPhoSitePlusP08727
Domaine pattern : Prosite (Expaxy)IF (PS00226)   
Domains : Interpro (EBI)IF    Intermediate_filament_CS    Keratin_I    Prefoldin   
Domain families : Pfam (Sanger)Filament (PF00038)   
Domain families : Pfam (NCBI)pfam00038   
Domain families : Smart (EMBL)Filament (SM01391)  
Conserved Domain (NCBI)KRT19
DMDM Disease mutations3880
Blocks (Seattle)KRT19
SuperfamilyP08727
Human Protein Atlas [tissue]ENSG00000171345-KRT19 [tissue]
Peptide AtlasP08727
HPRD01007
IPIIPI00479145   IPI00794644   
Protein Interaction databases
DIP (DOE-UCLA)P08727
IntAct (EBI)P08727
FunCoupENSG00000171345
BioGRIDKRT19
STRING (EMBL)KRT19
ZODIACKRT19
Ontologies - Pathways
QuickGOP08727
Ontology : AmiGOstructural constituent of cytoskeleton  protein binding  cytosol  intermediate filament  plasma membrane  Notch signaling pathway  structural constituent of muscle  dystrophin-associated glycoprotein complex  viral process  apicolateral plasma membrane  Z disc  keratinization  protein complex binding  sarcolemma  costamere  response to estrogen  sarcomere organization  cell differentiation involved in embryonic placenta development  extracellular exosome  cornification  cell periphery  terminal web  
Ontology : EGO-EBIstructural constituent of cytoskeleton  protein binding  cytosol  intermediate filament  plasma membrane  Notch signaling pathway  structural constituent of muscle  dystrophin-associated glycoprotein complex  viral process  apicolateral plasma membrane  Z disc  keratinization  protein complex binding  sarcolemma  costamere  response to estrogen  sarcomere organization  cell differentiation involved in embryonic placenta development  extracellular exosome  cornification  cell periphery  terminal web  
NDEx NetworkKRT19
Atlas of Cancer Signalling NetworkKRT19
Wikipedia pathwaysKRT19
Orthology - Evolution
OrthoDB3880
GeneTree (enSembl)ENSG00000171345
Phylogenetic Trees/Animal Genes : TreeFamKRT19
HOVERGENP08727
HOGENOMP08727
Homologs : HomoloGeneKRT19
Homology/Alignments : Family Browser (UCSC)KRT19
Gene fusions - Rearrangements
Tumor Fusion PortalKRT19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKRT19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRT19
dbVarKRT19
ClinVarKRT19
1000_GenomesKRT19 
Exome Variant ServerKRT19
ExAC (Exome Aggregation Consortium)ENSG00000171345
GNOMAD BrowserENSG00000171345
Genetic variants : HAPMAP3880
Genomic Variants (DGV)KRT19 [DGVbeta]
DECIPHERKRT19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKRT19 
Mutations
ICGC Data PortalKRT19 
TCGA Data PortalKRT19 
Broad Tumor PortalKRT19
OASIS PortalKRT19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKRT19  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKRT19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KRT19
DgiDB (Drug Gene Interaction Database)KRT19
DoCM (Curated mutations)KRT19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KRT19 (select a term)
intoGenKRT19
Cancer3DKRT19(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM148020   
Orphanet
DisGeNETKRT19
MedgenKRT19
Genetic Testing Registry KRT19
NextProtP08727 [Medical]
TSGene3880
GENETestsKRT19
Target ValidationKRT19
Huge Navigator KRT19 [HugePedia]
snp3D : Map Gene to Disease3880
BioCentury BCIQKRT19
ClinGenKRT19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3880
Chemical/Pharm GKB GenePA30225
Clinical trialKRT19
Miscellaneous
canSAR (ICR)KRT19 (select the gene name)
Probes
Litterature
PubMed214 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKRT19
EVEXKRT19
GoPubMedKRT19
iHOPKRT19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:19:19 CET 2017

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