Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KRT6A (keratin 6A)

Identity

Alias_namesKRT6C
KRT6D
keratin 6C
keratin 6D
keratin 6A, type II
Alias_symbol (synonym)CK6C
K6C
CK6D
K6D
HGNC (Hugo) KRT6A
LocusID (NCBI) 3853
Atlas_Id 49748
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 52880958 and ends at 52887181 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
APC (5q22.2) / KRT6A (12q13.13)CPSF1 (8q24.3) / KRT6A (12q13.13)KRT6A (12q13.13) / AP2B1 (17q12)
KRT6A (12q13.13) / KRT6A (12q13.13)KRT6A (12q13.13) / TUFT1 (1q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and Neck: Squamous cell carcinoma: an overview


External links

Nomenclature
HGNC (Hugo)KRT6A   6443
Cards
Entrez_Gene (NCBI)KRT6A  3853  keratin 6A
AliasesCK-6C; CK-6E; CK6A; CK6C; 
CK6D; K6A; K6C; K6D; KRT6C; KRT6D; PC3
GeneCards (Weizmann)KRT6A
Ensembl hg19 (Hinxton)ENSG00000205420 [Gene_View]  chr12:52880958-52887181 [Contig_View]  KRT6A [Vega]
Ensembl hg38 (Hinxton)ENSG00000205420 [Gene_View]  chr12:52880958-52887181 [Contig_View]  KRT6A [Vega]
ICGC DataPortalENSG00000205420
TCGA cBioPortalKRT6A
AceView (NCBI)KRT6A
Genatlas (Paris)KRT6A
WikiGenes3853
SOURCE (Princeton)KRT6A
Genetics Home Reference (NIH)KRT6A
Genomic and cartography
GoldenPath hg19 (UCSC)KRT6A  -     chr12:52880958-52887181 -  12q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KRT6A  -     12q13.13   [Description]    (hg38-Dec_2013)
EnsemblKRT6A - 12q13.13 [CytoView hg19]  KRT6A - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIKRT6A [Mapview hg19]  KRT6A [Mapview hg38]
OMIM148041   615726   
Gene and transcription
Genbank (Entrez)AK290245 AK299386 AK299428 AK301686 BC008807
RefSeq transcript (Entrez)NM_005554
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_008298 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)KRT6A
Cluster EST : UnigeneHs.700779 [ NCBI ]
CGAP (NCI)Hs.700779
Alternative Splicing GalleryENSG00000205420
Gene ExpressionKRT6A [ NCBI-GEO ]   KRT6A [ EBI - ARRAY_EXPRESS ]   KRT6A [ SEEK ]   KRT6A [ MEM ]
Gene Expression Viewer (FireBrowse)KRT6A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3853
GTEX Portal (Tissue expression)KRT6A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02538   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02538  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02538
Splice isoforms : SwissVarP02538
PhosPhoSitePlusP02538
Domaine pattern : Prosite (Expaxy)IF (PS00226)   
Domains : Interpro (EBI)IF    Intermediate_filament_CS    Keratin_2_head    Keratin_II   
Domain families : Pfam (Sanger)Filament (PF00038)    Keratin_2_head (PF16208)   
Domain families : Pfam (NCBI)pfam00038    pfam16208   
Conserved Domain (NCBI)KRT6A
DMDM Disease mutations3853
Blocks (Seattle)KRT6A
SuperfamilyP02538
Human Protein AtlasENSG00000205420
Peptide AtlasP02538
HPRD01011
IPIIPI00300725   IPI00909059   IPI00942257   
Protein Interaction databases
DIP (DOE-UCLA)P02538
IntAct (EBI)P02538
FunCoupENSG00000205420
BioGRIDKRT6A
STRING (EMBL)KRT6A
ZODIACKRT6A
Ontologies - Pathways
QuickGOP02538
Ontology : AmiGOstructural molecule activity  protein binding  intermediate filament  keratin filament  intermediate filament cytoskeleton organization  extracellular exosome  
Ontology : EGO-EBIstructural molecule activity  protein binding  intermediate filament  keratin filament  intermediate filament cytoskeleton organization  extracellular exosome  
NDEx NetworkKRT6A
Atlas of Cancer Signalling NetworkKRT6A
Wikipedia pathwaysKRT6A
Orthology - Evolution
OrthoDB3853
GeneTree (enSembl)ENSG00000205420
Phylogenetic Trees/Animal Genes : TreeFamKRT6A
HOVERGENP02538
HOGENOMP02538
Homologs : HomoloGeneKRT6A
Homology/Alignments : Family Browser (UCSC)KRT6A
Gene fusions - Rearrangements
Fusion : MitelmanAPC/KRT6A [5q22.2/12q13.13]  [t(5;12)(q22;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKRT6A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRT6A
dbVarKRT6A
ClinVarKRT6A
1000_GenomesKRT6A 
Exome Variant ServerKRT6A
ExAC (Exome Aggregation Consortium)KRT6A (select the gene name)
Genetic variants : HAPMAP3853
Genomic Variants (DGV)KRT6A [DGVbeta]
DECIPHER (Syndromes)12:52880958-52887181  ENSG00000205420
CONAN: Copy Number AnalysisKRT6A 
Mutations
ICGC Data PortalKRT6A 
TCGA Data PortalKRT6A 
Broad Tumor PortalKRT6A
OASIS PortalKRT6A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKRT6A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKRT6A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KRT6A
DgiDB (Drug Gene Interaction Database)KRT6A
DoCM (Curated mutations)KRT6A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KRT6A (select a term)
intoGenKRT6A
Cancer3DKRT6A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM148041    615726   
Orphanet2169   
MedgenKRT6A
Genetic Testing Registry KRT6A
NextProtP02538 [Medical]
TSGene3853
GENETestsKRT6A
Huge Navigator KRT6A [HugePedia]
snp3D : Map Gene to Disease3853
BioCentury BCIQKRT6A
ClinGenKRT6A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3853
Chemical/Pharm GKB GenePA30231
Clinical trialKRT6A
Miscellaneous
canSAR (ICR)KRT6A (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKRT6A
EVEXKRT6A
GoPubMedKRT6A
iHOPKRT6A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:41:29 CET 2016

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