Atlas of Genetics and Cytogenetics in Oncology and Haematology

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KRT7 (keratin 7)

Identity

Alias (NCBI)CK7
K2C7
K7
SCL
HGNC (Hugo) KRT7
HGNC Alias symbK7
CK7
K2C7
SCL
HGNC Alias namekeratin, type II cytoskeletal 7
 cytokeratin 7
 sarcolectin
 keratin, 55K type II cytoskeletal
HGNC Previous namekeratin 7, type II
LocusID (NCBI) 3855
Atlas_Id 45549
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 52233243 and ends at 52248921 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF3M (11p13) / KRT7 (12q13.13)EPHA10 (1p34.3) / KRT7 (12q13.13)KRT7 (12q13.13) / CHMP4B (20q11.22)
KRT7 (12q13.13) / KRT7 (12q13.13)KRT7 (12q13.13) / PLXNB2 (22q13.33)KRT7 (12q13.13) / PNPLA6 (19p13.2)
SHC3 (9q22.1) / KRT7 (12q13.13)STX4 (16p11.2) / KRT7 (12q13.13)VIM (10p13) / KRT7 (12q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)KRT7   6445
Cards
Entrez_Gene (NCBI)KRT7    keratin 7
AliasesCK7; K2C7; K7; SCL
GeneCards (Weizmann)KRT7
Ensembl hg19 (Hinxton)ENSG00000135480 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135480 [Gene_View]  ENSG00000135480 [Sequence]  chr12:52233243-52248921 [Contig_View]  KRT7 [Vega]
ICGC DataPortalENSG00000135480
TCGA cBioPortalKRT7
AceView (NCBI)KRT7
Genatlas (Paris)KRT7
SOURCE (Princeton)KRT7
Genetics Home Reference (NIH)KRT7
Genomic and cartography
GoldenPath hg38 (UCSC)KRT7  -     chr12:52233243-52248921 +  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KRT7  -     12q13.13   [Description]    (hg19-Feb_2009)
GoldenPathKRT7 - 12q13.13 [CytoView hg19]  KRT7 - 12q13.13 [CytoView hg38]
ImmunoBaseENSG00000135480
Genome Data Viewer NCBIKRT7 [Mapview hg19]  
OMIM148059   
Gene and transcription
Genbank (Entrez)AF509887 AJ238246 AK025881 AK128505 AK128848
RefSeq transcript (Entrez)NM_005556
Consensus coding sequences : CCDS (NCBI)KRT7
Gene ExpressionKRT7 [ NCBI-GEO ]   KRT7 [ EBI - ARRAY_EXPRESS ]   KRT7 [ SEEK ]   KRT7 [ MEM ]
Gene Expression Viewer (FireBrowse)KRT7 [ Firebrowse - Broad ]
GenevisibleExpression of KRT7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3855
GTEX Portal (Tissue expression)KRT7
Human Protein AtlasENSG00000135480-KRT7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08729   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08729  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08729
PhosPhoSitePlusP08729
Domaine pattern : Prosite (Expaxy)IF_ROD_1 (PS00226)    IF_ROD_2 (PS51842)   
Domains : Interpro (EBI)IF_conserved    IF_rod_dom    IF_rod_dom_coil1B    Keratin_2_head    Keratin_II   
Domain families : Pfam (Sanger)Filament (PF00038)    Keratin_2_head (PF16208)   
Domain families : Pfam (NCBI)pfam00038    pfam16208   
Domain families : Smart (EMBL)Filament (SM01391)  
Conserved Domain (NCBI)KRT7
PDB (RSDB)4XIF   
PDB Europe4XIF   
PDB (PDBSum)4XIF   
PDB (IMB)4XIF   
Structural Biology KnowledgeBase4XIF   
SCOP (Structural Classification of Proteins)4XIF   
CATH (Classification of proteins structures)4XIF   
SuperfamilyP08729
AlphaFold pdb e-kbP08729   
Human Protein Atlas [tissue]ENSG00000135480-KRT7 [tissue]
HPRD01014
Protein Interaction databases
DIP (DOE-UCLA)P08729
IntAct (EBI)P08729
BioGRIDKRT7
STRING (EMBL)KRT7
ZODIACKRT7
Ontologies - Pathways
QuickGOP08729
Ontology : AmiGOprotein binding  nucleus  cytoplasm  cytosol  intermediate filament  keratinization  keratin filament  extracellular exosome  cornification  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  cytosol  intermediate filament  keratinization  keratin filament  extracellular exosome  cornification  
NDEx NetworkKRT7
Atlas of Cancer Signalling NetworkKRT7
Wikipedia pathwaysKRT7
Orthology - Evolution
OrthoDB3855
GeneTree (enSembl)ENSG00000135480
Phylogenetic Trees/Animal Genes : TreeFamKRT7
Homologs : HomoloGeneKRT7
Homology/Alignments : Family Browser (UCSC)KRT7
Gene fusions - Rearrangements
Fusion : QuiverKRT7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKRT7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRT7
dbVarKRT7
ClinVarKRT7
MonarchKRT7
1000_GenomesKRT7 
Exome Variant ServerKRT7
GNOMAD BrowserENSG00000135480
Varsome BrowserKRT7
ACMGKRT7 variants
VarityP08729
Genomic Variants (DGV)KRT7 [DGVbeta]
DECIPHERKRT7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKRT7 
Mutations
ICGC Data PortalKRT7 
TCGA Data PortalKRT7 
Broad Tumor PortalKRT7
OASIS PortalKRT7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKRT7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKRT7
Mutations and Diseases : HGMDKRT7
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKRT7
DgiDB (Drug Gene Interaction Database)KRT7
DoCM (Curated mutations)KRT7
CIViC (Clinical Interpretations of Variants in Cancer)KRT7
Cancer3DKRT7
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM148059   
Orphanet
DisGeNETKRT7
MedgenKRT7
Genetic Testing Registry KRT7
NextProtP08729 [Medical]
GENETestsKRT7
Target ValidationKRT7
Huge Navigator KRT7 [HugePedia]
ClinGenKRT7
Clinical trials, drugs, therapy
MyCancerGenomeKRT7
Protein Interactions : CTDKRT7
Pharm GKB GenePA30233
PharosP08729
Clinical trialKRT7
Miscellaneous
canSAR (ICR)KRT7
HarmonizomeKRT7
DataMed IndexKRT7
Probes
Litterature
PubMed138 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKRT7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:15:25 CEST 2021
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