Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KRT7 (keratin 7)

Identity

Alias_nameskeratin 7
Alias_symbol (synonym)K7
CK7
K2C7
SCL
Other alias
HGNC (Hugo) KRT7
LocusID (NCBI) 3855
Atlas_Id 45549
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 52233170 and ends at 52248925 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EIF3M (11p13) / KRT7 (12q13.13)EPHA10 (1p34.3) / KRT7 (12q13.13)KRT7 (12q13.13) / CHMP4B (20q11.22)
KRT7 (12q13.13) / KRT7 (12q13.13)KRT7 (12q13.13) / PLXNB2 (22q13.33)KRT7 (12q13.13) / PNPLA6 (19p13.2)
SHC3 (9q22.1) / KRT7 (12q13.13)STX4 (16p11.2) / KRT7 (12q13.13)VIM (10p13) / KRT7 (12q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Liver: Fibrolamellar carcinoma
Kidney: Mucinous tubular and spindle cell carcinoma
Head and Neck: Thymus: Thymoma: an overview
Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)KRT7   6445
Cards
Entrez_Gene (NCBI)KRT7  3855  keratin 7
AliasesCK7; K2C7; K7; SCL
GeneCards (Weizmann)KRT7
Ensembl hg19 (Hinxton)ENSG00000135480 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135480 [Gene_View]  chr12:52233170-52248925 [Contig_View]  KRT7 [Vega]
ICGC DataPortalENSG00000135480
TCGA cBioPortalKRT7
AceView (NCBI)KRT7
Genatlas (Paris)KRT7
WikiGenes3855
SOURCE (Princeton)KRT7
Genetics Home Reference (NIH)KRT7
Genomic and cartography
GoldenPath hg38 (UCSC)KRT7  -     chr12:52233170-52248925 +  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KRT7  -     12q13.13   [Description]    (hg19-Feb_2009)
EnsemblKRT7 - 12q13.13 [CytoView hg19]  KRT7 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIKRT7 [Mapview hg19]  KRT7 [Mapview hg38]
OMIM148059   
Gene and transcription
Genbank (Entrez)AF509887 AJ238246 AK025881 AK128505 AK128848
RefSeq transcript (Entrez)NM_005556
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KRT7
Cluster EST : UnigeneHs.411501 [ NCBI ]
CGAP (NCI)Hs.411501
Alternative Splicing GalleryENSG00000135480
Gene ExpressionKRT7 [ NCBI-GEO ]   KRT7 [ EBI - ARRAY_EXPRESS ]   KRT7 [ SEEK ]   KRT7 [ MEM ]
Gene Expression Viewer (FireBrowse)KRT7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3855
GTEX Portal (Tissue expression)KRT7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08729   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08729  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08729
Splice isoforms : SwissVarP08729
PhosPhoSitePlusP08729
Domaine pattern : Prosite (Expaxy)IF (PS00226)   
Domains : Interpro (EBI)IF    Intermediate_filament_CS    Keratin_2_head    Keratin_II    Prefoldin   
Domain families : Pfam (Sanger)Filament (PF00038)    Keratin_2_head (PF16208)   
Domain families : Pfam (NCBI)pfam00038    pfam16208   
Domain families : Smart (EMBL)Filament (SM01391)  
Conserved Domain (NCBI)KRT7
DMDM Disease mutations3855
Blocks (Seattle)KRT7
PDB (SRS)4XIF   
PDB (PDBSum)4XIF   
PDB (IMB)4XIF   
PDB (RSDB)4XIF   
Structural Biology KnowledgeBase4XIF   
SCOP (Structural Classification of Proteins)4XIF   
CATH (Classification of proteins structures)4XIF   
SuperfamilyP08729
Human Protein AtlasENSG00000135480
Peptide AtlasP08729
HPRD01014
IPIIPI00306959   IPI00792841   IPI01010307   IPI00655639   IPI01021185   IPI00745280   IPI00954463   
Protein Interaction databases
DIP (DOE-UCLA)P08729
IntAct (EBI)P08729
FunCoupENSG00000135480
BioGRIDKRT7
STRING (EMBL)KRT7
ZODIACKRT7
Ontologies - Pathways
QuickGOP08729
Ontology : AmiGOstructural molecule activity  protein binding  nucleus  cytoplasm  cytosol  intermediate filament  viral process  keratinization  keratin filament  extracellular exosome  cornification  
Ontology : EGO-EBIstructural molecule activity  protein binding  nucleus  cytoplasm  cytosol  intermediate filament  viral process  keratinization  keratin filament  extracellular exosome  cornification  
NDEx NetworkKRT7
Atlas of Cancer Signalling NetworkKRT7
Wikipedia pathwaysKRT7
Orthology - Evolution
OrthoDB3855
GeneTree (enSembl)ENSG00000135480
Phylogenetic Trees/Animal Genes : TreeFamKRT7
HOVERGENP08729
HOGENOMP08729
Homologs : HomoloGeneKRT7
Homology/Alignments : Family Browser (UCSC)KRT7
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKRT7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRT7
dbVarKRT7
ClinVarKRT7
1000_GenomesKRT7 
Exome Variant ServerKRT7
ExAC (Exome Aggregation Consortium)KRT7 (select the gene name)
Genetic variants : HAPMAP3855
Genomic Variants (DGV)KRT7 [DGVbeta]
DECIPHERKRT7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKRT7 
Mutations
ICGC Data PortalKRT7 
TCGA Data PortalKRT7 
Broad Tumor PortalKRT7
OASIS PortalKRT7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKRT7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKRT7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KRT7
DgiDB (Drug Gene Interaction Database)KRT7
DoCM (Curated mutations)KRT7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KRT7 (select a term)
intoGenKRT7
Cancer3DKRT7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM148059   
Orphanet
MedgenKRT7
Genetic Testing Registry KRT7
NextProtP08729 [Medical]
TSGene3855
GENETestsKRT7
Target ValidationKRT7
Huge Navigator KRT7 [HugePedia]
snp3D : Map Gene to Disease3855
BioCentury BCIQKRT7
ClinGenKRT7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3855
Chemical/Pharm GKB GenePA30233
Clinical trialKRT7
Miscellaneous
canSAR (ICR)KRT7 (select the gene name)
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKRT7
EVEXKRT7
GoPubMedKRT7
iHOPKRT7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:57:19 CEST 2017

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