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KRT74 (keratin 74)

Identity

Alias_nameskeratin 74, type II
Alias_symbol (synonym)K6IRS4
KRT5C
KRT6IRS4
Other aliasADWH
HTSS2
HYPT3
HGNC (Hugo) KRT74
LocusID (NCBI) 121391
Atlas_Id 65039
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 52565819 and ends at 52573825 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KRT74   28929
Cards
Entrez_Gene (NCBI)KRT74  121391  keratin 74
AliasesADWH; HTSS2; HYPT3; K6IRS4; 
KRT5C; KRT6IRS4
GeneCards (Weizmann)KRT74
Ensembl hg19 (Hinxton)ENSG00000170484 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170484 [Gene_View]  chr12:52565819-52573825 [Contig_View]  KRT74 [Vega]
ICGC DataPortalENSG00000170484
TCGA cBioPortalKRT74
AceView (NCBI)KRT74
Genatlas (Paris)KRT74
WikiGenes121391
SOURCE (Princeton)KRT74
Genetics Home Reference (NIH)KRT74
Genomic and cartography
GoldenPath hg38 (UCSC)KRT74  -     chr12:52565819-52573825 -  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KRT74  -     12q13.13   [Description]    (hg19-Feb_2009)
EnsemblKRT74 - 12q13.13 [CytoView hg19]  KRT74 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIKRT74 [Mapview hg19]  KRT74 [Mapview hg38]
OMIM194300   608248   613981   614929   
Gene and transcription
Genbank (Entrez)AF086480 AI092341 AJ508777 BC160050
RefSeq transcript (Entrez)NM_175053
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KRT74
Cluster EST : UnigeneHs.660125 [ NCBI ]
CGAP (NCI)Hs.660125
Alternative Splicing GalleryENSG00000170484
Gene ExpressionKRT74 [ NCBI-GEO ]   KRT74 [ EBI - ARRAY_EXPRESS ]   KRT74 [ SEEK ]   KRT74 [ MEM ]
Gene Expression Viewer (FireBrowse)KRT74 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)121391
GTEX Portal (Tissue expression)KRT74
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7RTS7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7RTS7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7RTS7
Splice isoforms : SwissVarQ7RTS7
PhosPhoSitePlusQ7RTS7
Domaine pattern : Prosite (Expaxy)IF (PS00226)   
Domains : Interpro (EBI)IF    Intermediate_filament_CS    Keratin_2_head    Keratin_II   
Domain families : Pfam (Sanger)Filament (PF00038)    Keratin_2_head (PF16208)   
Domain families : Pfam (NCBI)pfam00038    pfam16208   
Domain families : Smart (EMBL)Filament (SM01391)  
Conserved Domain (NCBI)KRT74
DMDM Disease mutations121391
Blocks (Seattle)KRT74
SuperfamilyQ7RTS7
Human Protein AtlasENSG00000170484
Peptide AtlasQ7RTS7
HPRD10504
IPIIPI00329306   IPI01021464   
Protein Interaction databases
DIP (DOE-UCLA)Q7RTS7
IntAct (EBI)Q7RTS7
FunCoupENSG00000170484
BioGRIDKRT74
STRING (EMBL)KRT74
ZODIACKRT74
Ontologies - Pathways
QuickGOQ7RTS7
Ontology : AmiGOstructural molecule activity  cytoplasm  cytosol  keratinization  keratin filament  intermediate filament cytoskeleton organization  extracellular exosome  cornification  keratin filament binding  
Ontology : EGO-EBIstructural molecule activity  cytoplasm  cytosol  keratinization  keratin filament  intermediate filament cytoskeleton organization  extracellular exosome  cornification  keratin filament binding  
NDEx NetworkKRT74
Atlas of Cancer Signalling NetworkKRT74
Wikipedia pathwaysKRT74
Orthology - Evolution
OrthoDB121391
GeneTree (enSembl)ENSG00000170484
Phylogenetic Trees/Animal Genes : TreeFamKRT74
HOVERGENQ7RTS7
HOGENOMQ7RTS7
Homologs : HomoloGeneKRT74
Homology/Alignments : Family Browser (UCSC)KRT74
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKRT74 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRT74
dbVarKRT74
ClinVarKRT74
1000_GenomesKRT74 
Exome Variant ServerKRT74
ExAC (Exome Aggregation Consortium)KRT74 (select the gene name)
Genetic variants : HAPMAP121391
Genomic Variants (DGV)KRT74 [DGVbeta]
DECIPHERKRT74 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKRT74 
Mutations
ICGC Data PortalKRT74 
TCGA Data PortalKRT74 
Broad Tumor PortalKRT74
OASIS PortalKRT74 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKRT74  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKRT74
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch KRT74
DgiDB (Drug Gene Interaction Database)KRT74
DoCM (Curated mutations)KRT74 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KRT74 (select a term)
intoGenKRT74
Cancer3DKRT74(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM194300    608248    613981    614929   
Orphanet8571    10918    12032   
MedgenKRT74
Genetic Testing Registry KRT74
NextProtQ7RTS7 [Medical]
TSGene121391
GENETestsKRT74
Target ValidationKRT74
Huge Navigator KRT74 [HugePedia]
snp3D : Map Gene to Disease121391
BioCentury BCIQKRT74
ClinGenKRT74
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD121391
Chemical/Pharm GKB GenePA147357741
Clinical trialKRT74
Miscellaneous
canSAR (ICR)KRT74 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKRT74
EVEXKRT74
GoPubMedKRT74
iHOPKRT74
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:12:11 CEST 2017

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