Identity
HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
CARD2,CK-8,CK8,CYK8,K2C8,K8,KO
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3856
MIM: 148060
HGNC: 6446
Ensembl: ENSG00000170421
Variants:
dbSNP: 3856
ClinVar: 3856
TCGA: ENSG00000170421
COSMIC: KRT8
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Keratinization | REACTOME | R-HSA-6805567 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37995908 | 2024 | A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome. | 0 |
| 37995908 | 2024 | A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome. | 0 |
| 35040914 | 2022 | Association of Keratin 8 Level in Aqueous Humor With Outcomes of Intravitreal Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration. | 1 |
| 35080691 | 2022 | Autophagosome-lysosome fusion is facilitated by plectin-stabilized actin and keratin 8 during macroautophagic process. | 5 |
| 35958278 | 2022 | Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma. | 1 |
| 36045259 | 2022 | Keratin 8 is a scaffolding and regulatory protein of ERAD complexes. | 0 |
| 35040914 | 2022 | Association of Keratin 8 Level in Aqueous Humor With Outcomes of Intravitreal Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration. | 1 |
| 35080691 | 2022 | Autophagosome-lysosome fusion is facilitated by plectin-stabilized actin and keratin 8 during macroautophagic process. | 5 |
| 35958278 | 2022 | Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma. | 1 |
| 36045259 | 2022 | Keratin 8 is a scaffolding and regulatory protein of ERAD complexes. | 0 |
| 33472210 | 2021 | The Role of Keratin-8 and Keratin-18 Polymorphisms and Protein Levels in the Occurrence and Progression of Vocal Leukoplakia. | 1 |
| 33691026 | 2021 | A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker. | 7 |
| 33472210 | 2021 | The Role of Keratin-8 and Keratin-18 Polymorphisms and Protein Levels in the Occurrence and Progression of Vocal Leukoplakia. | 1 |
| 33691026 | 2021 | A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker. | 7 |
| 31515557 | 2020 | Keratin 8 Mutations Were Associated With Susceptibility to Chronic Hepatitis B and Related Progression. | 2 |
Citation
Dessen P
KRT8 (keratin 8)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45828/krt8
