Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KRT8 (keratin 8)

Identity

Alias_nameskeratin 8
Alias_symbol (synonym)CARD2
K8
CK8
CYK8
K2C8
KO
Other aliasCK-8
HGNC (Hugo) KRT8
LocusID (NCBI) 3856
Atlas_Id 45828
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 53290971 and ends at 53320253 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CLIP2 (7q11.23) / KRT8 (12q13.13)KRT8 (12q13.13) / CSAD (12q13.13)KRT8 (12q13.13) / PALM3 (19p13.12)
KRT8 (12q13.13) / VIM (10p13)PELI1 (2p14) / KRT8 (12q13.13)PELI1 2p14 / KRT8 12q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KRT8   6446
Cards
Entrez_Gene (NCBI)KRT8  3856  keratin 8
AliasesCARD2; CK-8; CK8; CYK8; 
K2C8; K8; KO
GeneCards (Weizmann)KRT8
Ensembl hg19 (Hinxton)ENSG00000170421 [Gene_View]  chr12:53290971-53320253 [Contig_View]  KRT8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000170421 [Gene_View]  chr12:53290971-53320253 [Contig_View]  KRT8 [Vega]
ICGC DataPortalENSG00000170421
TCGA cBioPortalKRT8
AceView (NCBI)KRT8
Genatlas (Paris)KRT8
WikiGenes3856
SOURCE (Princeton)KRT8
Genetics Home Reference (NIH)KRT8
Genomic and cartography
GoldenPath hg19 (UCSC)KRT8  -     chr12:53290971-53320253 -  12q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KRT8  -     12q13.13   [Description]    (hg38-Dec_2013)
EnsemblKRT8 - 12q13.13 [CytoView hg19]  KRT8 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIKRT8 [Mapview hg19]  KRT8 [Mapview hg38]
OMIM148060   
Gene and transcription
Genbank (Entrez)AI150751 AK222941 AK290938 AK310257 AK315826
RefSeq transcript (Entrez)NM_001256282 NM_001256293 NM_002273
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_008402 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)KRT8
Cluster EST : UnigeneHs.708445 [ NCBI ]
CGAP (NCI)Hs.708445
Alternative Splicing GalleryENSG00000170421
Gene ExpressionKRT8 [ NCBI-GEO ]   KRT8 [ EBI - ARRAY_EXPRESS ]   KRT8 [ SEEK ]   KRT8 [ MEM ]
Gene Expression Viewer (FireBrowse)KRT8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3856
GTEX Portal (Tissue expression)KRT8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05787   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05787  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05787
Splice isoforms : SwissVarP05787
PhosPhoSitePlusP05787
Domaine pattern : Prosite (Expaxy)IF (PS00226)   
Domains : Interpro (EBI)IF    Intermediate_filament_CS    Keratin_2_head    Keratin_II    Prefoldin   
Domain families : Pfam (Sanger)Filament (PF00038)    Keratin_2_head (PF16208)   
Domain families : Pfam (NCBI)pfam00038    pfam16208   
Conserved Domain (NCBI)KRT8
DMDM Disease mutations3856
Blocks (Seattle)KRT8
SuperfamilyP05787
Human Protein AtlasENSG00000170421
Peptide AtlasP05787
HPRD01015
IPIIPI00554648   IPI01023071   IPI01022891   IPI01022187   IPI01022329   IPI01021252   IPI01021414   IPI01021596   IPI01021753   IPI01020728   
Protein Interaction databases
DIP (DOE-UCLA)P05787
IntAct (EBI)P05787
FunCoupENSG00000170421
BioGRIDKRT8
STRING (EMBL)KRT8
ZODIACKRT8
Ontologies - Pathways
QuickGOP05787
Ontology : AmiGOstructural molecule activity  protein binding  nucleus  nucleoplasm  cytoplasm  intermediate filament  cell-cell junction  dystrophin-associated glycoprotein complex  viral process  nuclear matrix  Z disc  protein complex binding  tumor necrosis factor-mediated signaling pathway  sarcolemma  costamere  keratin filament  sarcomere organization  response to hydrostatic pressure  response to other organism  cell differentiation involved in embryonic placenta development  extracellular exosome  scaffold protein binding  extrinsic apoptotic signaling pathway  hepatocyte apoptotic process  
Ontology : EGO-EBIstructural molecule activity  protein binding  nucleus  nucleoplasm  cytoplasm  intermediate filament  cell-cell junction  dystrophin-associated glycoprotein complex  viral process  nuclear matrix  Z disc  protein complex binding  tumor necrosis factor-mediated signaling pathway  sarcolemma  costamere  keratin filament  sarcomere organization  response to hydrostatic pressure  response to other organism  cell differentiation involved in embryonic placenta development  extracellular exosome  scaffold protein binding  extrinsic apoptotic signaling pathway  hepatocyte apoptotic process  
NDEx NetworkKRT8
Atlas of Cancer Signalling NetworkKRT8
Wikipedia pathwaysKRT8
Orthology - Evolution
OrthoDB3856
GeneTree (enSembl)ENSG00000170421
Phylogenetic Trees/Animal Genes : TreeFamKRT8
HOVERGENP05787
HOGENOMP05787
Homologs : HomoloGeneKRT8
Homology/Alignments : Family Browser (UCSC)KRT8
Gene fusions - Rearrangements
Fusion : MitelmanPELI1/KRT8 [2p14/12q13.13]  [t(2;12)(p14;q13)]  
Fusion: TCGAPELI1 2p14 KRT8 12q13.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKRT8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRT8
dbVarKRT8
ClinVarKRT8
1000_GenomesKRT8 
Exome Variant ServerKRT8
ExAC (Exome Aggregation Consortium)KRT8 (select the gene name)
Genetic variants : HAPMAP3856
Genomic Variants (DGV)KRT8 [DGVbeta]
DECIPHER (Syndromes)12:53290971-53320253  ENSG00000170421
CONAN: Copy Number AnalysisKRT8 
Mutations
ICGC Data PortalKRT8 
TCGA Data PortalKRT8 
Broad Tumor PortalKRT8
OASIS PortalKRT8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKRT8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKRT8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KRT8
DgiDB (Drug Gene Interaction Database)KRT8
DoCM (Curated mutations)KRT8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KRT8 (select a term)
intoGenKRT8
Cancer3DKRT8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM148060   
Orphanet
MedgenKRT8
Genetic Testing Registry KRT8
NextProtP05787 [Medical]
TSGene3856
GENETestsKRT8
Huge Navigator KRT8 [HugePedia]
snp3D : Map Gene to Disease3856
BioCentury BCIQKRT8
ClinGenKRT8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3856
Chemical/Pharm GKB GenePA30234
Clinical trialKRT8
Miscellaneous
canSAR (ICR)KRT8 (select the gene name)
Probes
Litterature
PubMed188 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKRT8
EVEXKRT8
GoPubMedKRT8
iHOPKRT8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:06:34 CEST 2017

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