Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KRT86 (keratin 86)

Identity

Alias_namesKRTHB6
keratin, hair, basic, 6 (monilethrix)
keratin 86, type II
Alias_symbol (synonym)MNX
Hb6
Other aliasHB6
Hb1
K86
KRTHB1
HGNC (Hugo) KRT86
LocusID (NCBI) 3892
Atlas_Id 41106
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 52274645 and ends at 52309163 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IPO8 (12p11.21) / KRT86 (12q13.13)KRT86 (12q13.13) / ITGA6 (2q31.1)KRT86 (12q13.13) / KRT86 (12q13.13)
KRT86 (12q13.13) / NCL (2q37.1)IPO8 12p11.21 / KRT86 12q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KRT86   6463
Cards
Entrez_Gene (NCBI)KRT86  3892  keratin 86
AliasesHB6; Hb1; K86; KRTHB1; 
KRTHB6; MNX
GeneCards (Weizmann)KRT86
Ensembl hg19 (Hinxton)ENSG00000170442 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170442 [Gene_View]  chr12:52274645-52309163 [Contig_View]  KRT86 [Vega]
ICGC DataPortalENSG00000170442
TCGA cBioPortalKRT86
AceView (NCBI)KRT86
Genatlas (Paris)KRT86
WikiGenes3892
SOURCE (Princeton)KRT86
Genetics Home Reference (NIH)KRT86
Genomic and cartography
GoldenPath hg38 (UCSC)KRT86  -     chr12:52274645-52309163 +  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KRT86  -     12q13.13   [Description]    (hg19-Feb_2009)
EnsemblKRT86 - 12q13.13 [CytoView hg19]  KRT86 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIKRT86 [Mapview hg19]  KRT86 [Mapview hg38]
OMIM158000   601928   
Gene and transcription
Genbank (Entrez)AI368926 AK292237 AK297794 BC069585 BG216771
RefSeq transcript (Entrez)NM_001320198 NM_002284
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KRT86
Cluster EST : UnigeneHs.733602 [ NCBI ]
CGAP (NCI)Hs.733602
Alternative Splicing GalleryENSG00000170442
Gene ExpressionKRT86 [ NCBI-GEO ]   KRT86 [ EBI - ARRAY_EXPRESS ]   KRT86 [ SEEK ]   KRT86 [ MEM ]
Gene Expression Viewer (FireBrowse)KRT86 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3892
GTEX Portal (Tissue expression)KRT86
Human Protein AtlasENSG00000170442-KRT86 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43790   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43790  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43790
Splice isoforms : SwissVarO43790
PhosPhoSitePlusO43790
Domaine pattern : Prosite (Expaxy)IF (PS00226)   
Domains : Interpro (EBI)IF    Intermediate_filament_CS    Keratin_2_head    Keratin_II   
Domain families : Pfam (Sanger)Filament (PF00038)    Keratin_2_head (PF16208)   
Domain families : Pfam (NCBI)pfam00038    pfam16208   
Domain families : Smart (EMBL)Filament (SM01391)  
Conserved Domain (NCBI)KRT86
DMDM Disease mutations3892
Blocks (Seattle)KRT86
SuperfamilyO43790
Human Protein Atlas [tissue]ENSG00000170442-KRT86 [tissue]
Peptide AtlasO43790
HPRD03567
IPIIPI00182655   
Protein Interaction databases
DIP (DOE-UCLA)O43790
IntAct (EBI)O43790
FunCoupENSG00000170442
BioGRIDKRT86
STRING (EMBL)KRT86
ZODIACKRT86
Ontologies - Pathways
QuickGOO43790
Ontology : AmiGOstructural molecule activity  protein binding  extracellular space  cytosol  keratinization  keratin filament  extracellular exosome  cornification  
Ontology : EGO-EBIstructural molecule activity  protein binding  extracellular space  cytosol  keratinization  keratin filament  extracellular exosome  cornification  
NDEx NetworkKRT86
Atlas of Cancer Signalling NetworkKRT86
Wikipedia pathwaysKRT86
Orthology - Evolution
OrthoDB3892
GeneTree (enSembl)ENSG00000170442
Phylogenetic Trees/Animal Genes : TreeFamKRT86
HOVERGENO43790
HOGENOMO43790
Homologs : HomoloGeneKRT86
Homology/Alignments : Family Browser (UCSC)KRT86
Gene fusions - Rearrangements
Fusion : MitelmanIPO8/KRT86 [12p11.21/12q13.13]  [t(12;12)(p11;q13)]  
Fusion: TCGA_MDACCIPO8 12p11.21 KRT86 12q13.13 PRAD
Tumor Fusion PortalKRT86
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKRT86 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRT86
dbVarKRT86
ClinVarKRT86
1000_GenomesKRT86 
Exome Variant ServerKRT86
ExAC (Exome Aggregation Consortium)ENSG00000170442
GNOMAD BrowserENSG00000170442
Genetic variants : HAPMAP3892
Genomic Variants (DGV)KRT86 [DGVbeta]
DECIPHERKRT86 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKRT86 
Mutations
ICGC Data PortalKRT86 
TCGA Data PortalKRT86 
Broad Tumor PortalKRT86
OASIS PortalKRT86 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKRT86  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKRT86
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KRT86
DgiDB (Drug Gene Interaction Database)KRT86
DoCM (Curated mutations)KRT86 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KRT86 (select a term)
intoGenKRT86
Cancer3DKRT86(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM158000    601928   
Orphanet8581   
DisGeNETKRT86
MedgenKRT86
Genetic Testing Registry KRT86
NextProtO43790 [Medical]
TSGene3892
GENETestsKRT86
Target ValidationKRT86
Huge Navigator KRT86 [HugePedia]
snp3D : Map Gene to Disease3892
BioCentury BCIQKRT86
ClinGenKRT86
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3892
Chemical/Pharm GKB GenePA30252
Clinical trialKRT86
Miscellaneous
canSAR (ICR)KRT86 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKRT86
EVEXKRT86
GoPubMedKRT86
iHOPKRT86
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:19:22 CET 2017

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