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KSR2 (kinase suppressor of ras 2)

Identity

Other namesFLJ25965
HGNC (Hugo) KSR2
Location 12q24.22
Location_base_pair Starts at 116375200 and ends at 116890411 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)KSR2   18610
Entrez_Gene (NCBI)KSR2  283455  kinase suppressor of ras 2
Cards
GeneCards (Weizmann)KSR2
Ensembl (Hinxton)ENSG00000173064 [Gene_View]  KSR2 [Vega]
AceView (NCBI)KSR2
Genatlas (Paris)KSR2
euGene (Indiana)283455
SOURCE (Stanford)NM_173598
Gene Expression (Array Express) ENSG00000173064
Genomic and cartography
GoldenPath (UCSC)KSR2  -  12q24.22   chr12:116375200-116890411 -  12q24.22   [Description]    (hg18-March_2006)
EnsemblKSR2 - 12q24.22 [CytoView]
Mapping of homologs : NCBIKSR2 [Mapview]
OMIM610737   
Gene and transcription
Gene : Genbank (Entrez)AK098831 AY345972 BC107106 BC107107 BC127603
Reference sequence (RefSeq transcript) :SRSNM_173598
Reference transcript : EntrezNM_173598
RefSeq genomic : SRSAC_000055 AC_000144 NC_000012 NT_009775 NW_001838063 NW_925395
RefSeq genomic : EntrezAC_000055 AC_000144 NC_000012 NT_009775 NW_001838063 NW_925395
Consensus coding sequences : CCDS NCBIKSR2
Cluster EST : UnigeneHs.375836 [ SRS ] Hs.375836 [ NCBI ]
Alternative Splicing : Fast-db (Paris)13915
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ6VAB6 (SRS) Q6VAB6 (Expasy) Q6VAB6 (Uniprot)
With graphics : InterProQ6VAB6
Splice isoforms : VarSplice FASTAQ6VAB6(VarSplice FASTA)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domain pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (SRS)Kinase-like_dom    Prot_Kinase_C-like_PE/DAG_bd    Prot_kinase_cat_dom    Ser/Thr_prot_kinase_AS    Tyr_prot_kinase_cat_dom   
Domains : Interpro (EBI)Kinase-like_dom    Prot_Kinase_C-like_PE/DAG_bd    Prot_kinase_cat_dom    Ser/Thr_prot_kinase_AS    Tyr_prot_kinase_cat_dom   
Related proteins : CluSTrQ6VAB6
Domain families : Pfam SRSPkinase_Tyr (PF07714)   
Domain families : Pfam SangerPkinase_Tyr (PF07714)   
Domain families : Pfam NCBIpfam07714   
Domain families : Smart EMBLC1 (SM00109)  
Blocks (Seattle)Q6VAB6
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD13952
Protein Interaction databases
DIP (DOE-UCLA)Q6VAB6
IntAct (EBI)Q6VAB6
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIKSR2
SNP : GeneSNP UtahKSR2
SNP : HGBaseKSR2
Genetic variants : HAPMAPKSR2
Somatic Mutations in Cancer : COSMICKSR2 
Mutations and Diseases : HGMDKSR2
Hereditary diseases : OMIM610737   
Hereditary diseases : GENETests610737   
Diseases : Genetic AssociationKSR2
General knowledge
Homologs : HomoloGeneKSR2
Homology/Alignments : Family Browser UCSCKSR2
Phylogenetic Trees/Animal Genes : TreeFamKSR2
Chemical/Protein Interactions : CTD283455
Keywords Ontology : AmiGOprotein serine/threonine kinase activity  protein tyrosine kinase activity  ATP binding  cytoplasm  protein amino acid phosphorylation  intracellular signaling cascade  zinc ion binding  membrane  extrinsic to membrane  metal ion binding  
Keywords Ontology : EGO-EBIprotein serine/threonine kinase activity  protein tyrosine kinase activity  ATP binding  cytoplasm  protein amino acid phosphorylation  intracellular signaling cascade  zinc ion binding  membrane  extrinsic to membrane  metal ion binding  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesKSR2 Related clones (RZPD - Berlin)
Literature
PubMed9 Pubmed reference(s) in Entrez
PubGeneKSR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:40:45 CET 2010
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