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KSR2 (kinase suppressor of ras 2)

Identity

Alias_symbol (synonym)FLJ25965
Other alias-
HGNC (Hugo) KSR2
LocusID (NCBI) 283455
Atlas_Id 43336
Location 12q24.22  [Link to chromosome band 12q24]
Location_base_pair Starts at 117453012 and ends at 117968223 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C12orf66 (12q14.2) / KSR2 (12q24.22)KDM2B (12q24.31) / KSR2 (12q24.22)KSR2 (12q24.22) / P2RX4 (12q24.31)
KSR2 (12q24.22) / SETD1A (16p11.2)KSR2 (12q24.22) / SETMAR (3p26.1)KSR2 (12q24.22) / SPOCK1 (5q31.2)
KDM2B 12q24.31 / KSR2 12q24.22KSR2 12q24.22 / P2RX4 12q24.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KSR2   18610
Cards
Entrez_Gene (NCBI)KSR2  283455  kinase suppressor of ras 2
Aliases
GeneCards (Weizmann)KSR2
Ensembl hg19 (Hinxton)ENSG00000171435 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171435 [Gene_View]  chr12:117453012-117968223 [Contig_View]  KSR2 [Vega]
ICGC DataPortalENSG00000171435
TCGA cBioPortalKSR2
AceView (NCBI)KSR2
Genatlas (Paris)KSR2
WikiGenes283455
SOURCE (Princeton)KSR2
Genetics Home Reference (NIH)KSR2
Genomic and cartography
GoldenPath hg38 (UCSC)KSR2  -     chr12:117453012-117968223 -  12q24.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KSR2  -     12q24.22   [Description]    (hg19-Feb_2009)
EnsemblKSR2 - 12q24.22 [CytoView hg19]  KSR2 - 12q24.22 [CytoView hg38]
Mapping of homologs : NCBIKSR2 [Mapview hg19]  KSR2 [Mapview hg38]
OMIM610737   
Gene and transcription
Genbank (Entrez)AK098831 AY345972 BC107106 BC107107 BC127603
RefSeq transcript (Entrez)NM_173598
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KSR2
Cluster EST : UnigeneHs.375836 [ NCBI ]
CGAP (NCI)Hs.375836
Alternative Splicing GalleryENSG00000171435
Gene ExpressionKSR2 [ NCBI-GEO ]   KSR2 [ EBI - ARRAY_EXPRESS ]   KSR2 [ SEEK ]   KSR2 [ MEM ]
Gene Expression Viewer (FireBrowse)KSR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)283455
GTEX Portal (Tissue expression)KSR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6VAB6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6VAB6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6VAB6
Splice isoforms : SwissVarQ6VAB6
PhosPhoSitePlusQ6VAB6
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)Kinase-like_dom    KSR_SAM-like_dom    PE/DAG-bd    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)KSR1-SAM (PF13543)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam13543    pfam07714   
Domain families : Smart (EMBL)C1 (SM00109)  S_TKc (SM00220)  
Conserved Domain (NCBI)KSR2
DMDM Disease mutations283455
Blocks (Seattle)KSR2
PDB (SRS)2Y4I    5KKR   
PDB (PDBSum)2Y4I    5KKR   
PDB (IMB)2Y4I    5KKR   
PDB (RSDB)2Y4I    5KKR   
Structural Biology KnowledgeBase2Y4I    5KKR   
SCOP (Structural Classification of Proteins)2Y4I    5KKR   
CATH (Classification of proteins structures)2Y4I    5KKR   
SuperfamilyQ6VAB6
Human Protein AtlasENSG00000171435
Peptide AtlasQ6VAB6
HPRD13952
IPIIPI00414043   IPI00167121   IPI01021947   
Protein Interaction databases
DIP (DOE-UCLA)Q6VAB6
IntAct (EBI)Q6VAB6
FunCoupENSG00000171435
BioGRIDKSR2
STRING (EMBL)KSR2
ZODIACKSR2
Ontologies - Pathways
QuickGOQ6VAB6
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  signal transducer activity  ATP binding  cytosol  plasma membrane  protein phosphorylation  Ras protein signal transduction  calcium-mediated signaling  positive regulation of MAPK cascade  metal ion binding  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  signal transducer activity  ATP binding  cytosol  plasma membrane  protein phosphorylation  Ras protein signal transduction  calcium-mediated signaling  positive regulation of MAPK cascade  metal ion binding  
NDEx NetworkKSR2
Atlas of Cancer Signalling NetworkKSR2
Wikipedia pathwaysKSR2
Orthology - Evolution
OrthoDB283455
GeneTree (enSembl)ENSG00000171435
Phylogenetic Trees/Animal Genes : TreeFamKSR2
HOVERGENQ6VAB6
HOGENOMQ6VAB6
Homologs : HomoloGeneKSR2
Homology/Alignments : Family Browser (UCSC)KSR2
Gene fusions - Rearrangements
Fusion : MitelmanKDM2B/KSR2 [12q24.31/12q24.22]  [t(12;12)(q24;q24)]  
Fusion : MitelmanKSR2/P2RX4 [12q24.22/12q24.31]  [t(12;12)(q24;q24)]  
Fusion : MitelmanKSR2/SETMAR [12q24.22/3p26.1]  [t(3;12)(p26;q24)]  
Fusion: TCGAKDM2B 12q24.31 KSR2 12q24.22 GBM
Fusion: TCGAKSR2 12q24.22 P2RX4 12q24.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKSR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KSR2
dbVarKSR2
ClinVarKSR2
1000_GenomesKSR2 
Exome Variant ServerKSR2
ExAC (Exome Aggregation Consortium)KSR2 (select the gene name)
Genetic variants : HAPMAP283455
Genomic Variants (DGV)KSR2 [DGVbeta]
DECIPHERKSR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKSR2 
Mutations
ICGC Data PortalKSR2 
TCGA Data PortalKSR2 
Broad Tumor PortalKSR2
OASIS PortalKSR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKSR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKSR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KSR2
DgiDB (Drug Gene Interaction Database)KSR2
DoCM (Curated mutations)KSR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KSR2 (select a term)
intoGenKSR2
Cancer3DKSR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610737   
Orphanet
MedgenKSR2
Genetic Testing Registry KSR2
NextProtQ6VAB6 [Medical]
TSGene283455
GENETestsKSR2
Target ValidationKSR2
Huge Navigator KSR2 [HugePedia]
snp3D : Map Gene to Disease283455
BioCentury BCIQKSR2
ClinGenKSR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD283455
Chemical/Pharm GKB GenePA134914125
Clinical trialKSR2
Miscellaneous
canSAR (ICR)KSR2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKSR2
EVEXKSR2
GoPubMedKSR2
iHOPKSR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:40:04 CEST 2017

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