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KTN1 (kinectin 1)

Identity

Alias_nameskinectin 1 (kinesin receptor)
Alias_symbol (synonym)KIAA0004
CG1
KNT
Other aliasMU-RMS-40.19
HGNC (Hugo) KTN1
LocusID (NCBI) 3895
Atlas_Id 41108
Location 14q22.3  [Link to chromosome band 14q22]
Location_base_pair Starts at 55580207 and ends at 55684584 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DCLK1 (13q13.3) / KTN1 (14q22.3)KTN1 (14q22.3) / DOCK2 (5q35.1)KTN1 (14q22.3) / DRGX (10q11.23)
KTN1 (14q22.3) / KTN1 (14q22.3)KTN1 (14q22.3) / MECP2 (Xq28)KTN1 (14q22.3) / PRKCSH (19p13.2)
KTN1 (14q22.3) / RET (10q11.21)LRBA (4q31.3) / KTN1 (14q22.3)NTN4 (12q22) / KTN1 (14q22.3)
RET (10q11.21) / KTN1 (14q22.3)WARS (14q32.2) / KTN1 (14q22.3)KTN1 RET 10q11.21
KTN1 14q22.3 / DRGX 10q11.23KTN1 14q22.3 / PRKCSH 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(2;14)(p23;q22) KTN1/ALK
t(10;14)(q11;q22) KTN1/DRGX
t(10;14)(q11;q22) KTN1/RET
t(14;14)(q22;q32) WARS/KTN1
t(14;19)(q22;p13) KTN1/PRKCSH

External links

Nomenclature
HGNC (Hugo)KTN1   6467
Cards
Entrez_Gene (NCBI)KTN1  3895  kinectin 1
AliasesCG1; KNT; MU-RMS-40.19
GeneCards (Weizmann)KTN1
Ensembl hg19 (Hinxton)ENSG00000126777 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126777 [Gene_View]  chr14:55580207-55684584 [Contig_View]  KTN1 [Vega]
ICGC DataPortalENSG00000126777
TCGA cBioPortalKTN1
AceView (NCBI)KTN1
Genatlas (Paris)KTN1
WikiGenes3895
SOURCE (Princeton)KTN1
Genetics Home Reference (NIH)KTN1
Genomic and cartography
GoldenPath hg38 (UCSC)KTN1  -     chr14:55580207-55684584 +  14q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KTN1  -     14q22.3   [Description]    (hg19-Feb_2009)
EnsemblKTN1 - 14q22.3 [CytoView hg19]  KTN1 - 14q22.3 [CytoView hg38]
Mapping of homologs : NCBIKTN1 [Mapview hg19]  KTN1 [Mapview hg38]
OMIM600381   
Gene and transcription
Genbank (Entrez)AJ270687 AK055870 AK124180 AK125499 AK300703
RefSeq transcript (Entrez)NM_001079521 NM_001079522 NM_001271014 NM_004986 NM_182926
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KTN1
Cluster EST : UnigeneHs.687012 [ NCBI ]
CGAP (NCI)Hs.687012
Alternative Splicing GalleryENSG00000126777
Gene ExpressionKTN1 [ NCBI-GEO ]   KTN1 [ EBI - ARRAY_EXPRESS ]   KTN1 [ SEEK ]   KTN1 [ MEM ]
Gene Expression Viewer (FireBrowse)KTN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3895
GTEX Portal (Tissue expression)KTN1
Human Protein AtlasENSG00000126777-KTN1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UP2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UP2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UP2
Splice isoforms : SwissVarQ86UP2
PhosPhoSitePlusQ86UP2
Domains : Interpro (EBI)Kinectin   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)KTN1
DMDM Disease mutations3895
Blocks (Seattle)KTN1
SuperfamilyQ86UP2
Human Protein Atlas [tissue]ENSG00000126777-KTN1 [tissue]
Peptide AtlasQ86UP2
HPRD02661
IPIIPI00328753   IPI00337736   IPI00909030   IPI01025097   IPI01025754   IPI01026585   IPI01015170   IPI01026134   IPI01024970   IPI01024881   IPI01024877   IPI01024773   IPI01025601   IPI01025512   IPI00783726   
Protein Interaction databases
DIP (DOE-UCLA)Q86UP2
IntAct (EBI)Q86UP2
FunCoupENSG00000126777
BioGRIDKTN1
STRING (EMBL)KTN1
ZODIACKTN1
Ontologies - Pathways
QuickGOQ86UP2
Ontology : AmiGORNA binding  protein binding  endoplasmic reticulum  endoplasmic reticulum lumen  endoplasmic reticulum membrane  integral component of plasma membrane  microtubule-based movement  membrane  integral component of membrane  kinesin binding  post-translational protein modification  cellular protein metabolic process  cadherin binding  
Ontology : EGO-EBIRNA binding  protein binding  endoplasmic reticulum  endoplasmic reticulum lumen  endoplasmic reticulum membrane  integral component of plasma membrane  microtubule-based movement  membrane  integral component of membrane  kinesin binding  post-translational protein modification  cellular protein metabolic process  cadherin binding  
NDEx NetworkKTN1
Atlas of Cancer Signalling NetworkKTN1
Wikipedia pathwaysKTN1
Orthology - Evolution
OrthoDB3895
GeneTree (enSembl)ENSG00000126777
Phylogenetic Trees/Animal Genes : TreeFamKTN1
HOVERGENQ86UP2
HOGENOMQ86UP2
Homologs : HomoloGeneKTN1
Homology/Alignments : Family Browser (UCSC)KTN1
Gene fusions - Rearrangements
Fusion : MitelmanKTN1/DRGX [14q22.3/10q11.23]  
Fusion : MitelmanKTN1/PRKCSH [14q22.3/19p13.2]  [t(14;19)(q22;p13)]  
Fusion : MitelmanKTN1/RET [14q22.3/10q11.21]  [t(10;14)(q11;q22)]  
Fusion : MitelmanWARS/KTN1 [14q32.2/14q22.3]  [t(14;14)(q22;q32)]  
Fusion: TCGA_MDACCKTN1 14q22.3 DRGX 10q11.23 BLCA
Fusion: TCGA_MDACCKTN1 14q22.3 PRKCSH 19p13.2 LUAD
Fusion PortalKTN1 14q22.3 DRGX 10q11.23 BLCA
Fusion PortalKTN1 14q22.3 PRKCSH 19p13.2 LUAD
Fusion : QuiverKTN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKTN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KTN1
dbVarKTN1
ClinVarKTN1
1000_GenomesKTN1 
Exome Variant ServerKTN1
ExAC (Exome Aggregation Consortium)ENSG00000126777
GNOMAD BrowserENSG00000126777
Genetic variants : HAPMAP3895
Genomic Variants (DGV)KTN1 [DGVbeta]
DECIPHERKTN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKTN1 
Mutations
ICGC Data PortalKTN1 
TCGA Data PortalKTN1 
Broad Tumor PortalKTN1
OASIS PortalKTN1 [ Somatic mutations - Copy number]
Cancer Gene: CensusKTN1 
Somatic Mutations in Cancer : COSMICKTN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKTN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KTN1
DgiDB (Drug Gene Interaction Database)KTN1
DoCM (Curated mutations)KTN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KTN1 (select a term)
intoGenKTN1
Cancer3DKTN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600381   
Orphanet
DisGeNETKTN1
MedgenKTN1
Genetic Testing Registry KTN1
NextProtQ86UP2 [Medical]
TSGene3895
GENETestsKTN1
Target ValidationKTN1
Huge Navigator KTN1 [HugePedia]
snp3D : Map Gene to Disease3895
BioCentury BCIQKTN1
ClinGenKTN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3895
Chemical/Pharm GKB GenePA30256
Clinical trialKTN1
Miscellaneous
canSAR (ICR)KTN1 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKTN1
EVEXKTN1
GoPubMedKTN1
iHOPKTN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:19:53 CET 2018
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