KYNU (kynureninase)

2014-11-01  

Identity

HGNC
KYNU
LOCATION
2q22.2
LOCUSID
8942
ALIAS
KYNUU,VCRL2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8942
MIM: 605197
HGNC: 6469
Ensembl: ENSG00000115919

Variants:

dbSNP: 8942
ClinVar: 8942
TCGA: ENSG00000115919
COSMIC: KYNU

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115919ENST00000264170Q16719
ENSG00000115919ENST00000375773Q16719
ENSG00000115919ENST00000409512Q16719
ENSG00000115919ENST00000410015B8ZZA3
ENSG00000115919ENST00000424385F8WEP1
ENSG00000115919ENST00000612147A0A087WYM2
ENSG00000115919ENST00000613664A0A087WYQ7
ENSG00000115919ENST00000621320A0A087X297

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tryptophan metabolismKEGGko00380
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Tryptophan catabolismREACTOMER-HSA-71240
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
267259962016The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases.16
160808022005[A polymorphism of kynureninase gene in a hypertensive candidate chromosomal region is associated with essential hypertension].3
160808022005[A polymorphism of kynureninase gene in a hypertensive candidate chromosomal region is associated with essential hypertension].3
220129862011A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population.3

Citation

Dessen P

KYNU (kynureninase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/65151/kynu