Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KYNU (kynureninase)

Identity

Alias_nameskynureninase (L-kynurenine hydrolase)
Other aliasKYNUU
HGNC (Hugo) KYNU
LocusID (NCBI) 8942
Atlas_Id 65151
Location 2q22.2  [Link to chromosome band 2q22]
Location_base_pair Starts at 142877626 and ends at 142989537 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGAP15 (2q22.2) / KYNU (2q22.2)HTN1 (4q13.3) / KYNU (2q22.2)KYNU (2q22.2) / KYNU (2q22.2)
KYNU (2q22.2) / PAIP1 (5p12)PBRM1 (3p21.1) / KYNU (2q22.2)TGOLN2 (2p11.2) / KYNU (2q22.2)
PBRM1 KYNUARHGAP15 KYNU

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KYNU   6469
Cards
Entrez_Gene (NCBI)KYNU  8942  kynureninase
AliasesKYNUU
GeneCards (Weizmann)KYNU
Ensembl hg19 (Hinxton)ENSG00000115919 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115919 [Gene_View]  chr2:142877626-142989537 [Contig_View]  KYNU [Vega]
ICGC DataPortalENSG00000115919
TCGA cBioPortalKYNU
AceView (NCBI)KYNU
Genatlas (Paris)KYNU
WikiGenes8942
SOURCE (Princeton)KYNU
Genetics Home Reference (NIH)KYNU
Genomic and cartography
GoldenPath hg38 (UCSC)KYNU  -     chr2:142877626-142989537 +  2q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KYNU  -     2q22.2   [Description]    (hg19-Feb_2009)
EnsemblKYNU - 2q22.2 [CytoView hg19]  KYNU - 2q22.2 [CytoView hg38]
Mapping of homologs : NCBIKYNU [Mapview hg19]  KYNU [Mapview hg38]
OMIM236800   605197   
Gene and transcription
Genbank (Entrez)AK223426 AK290900 AK292095 AK315343 AL548658
RefSeq transcript (Entrez)NM_001032998 NM_001199241 NM_003937
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KYNU
Cluster EST : UnigeneHs.470126 [ NCBI ]
CGAP (NCI)Hs.470126
Alternative Splicing GalleryENSG00000115919
Gene ExpressionKYNU [ NCBI-GEO ]   KYNU [ EBI - ARRAY_EXPRESS ]   KYNU [ SEEK ]   KYNU [ MEM ]
Gene Expression Viewer (FireBrowse)KYNU [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8942
GTEX Portal (Tissue expression)KYNU
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16719   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16719  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16719
Splice isoforms : SwissVarQ16719
PhosPhoSitePlusQ16719
Domains : Interpro (EBI)Aminotrans_V_dom    Kynureninase    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1    PyrdxlP-dep_Trfase_major_sub2   
Domain families : Pfam (Sanger)Aminotran_5 (PF00266)   
Domain families : Pfam (NCBI)pfam00266   
Conserved Domain (NCBI)KYNU
DMDM Disease mutations8942
Blocks (Seattle)KYNU
PDB (SRS)2HZP    3E9K   
PDB (PDBSum)2HZP    3E9K   
PDB (IMB)2HZP    3E9K   
PDB (RSDB)2HZP    3E9K   
Structural Biology KnowledgeBase2HZP    3E9K   
SCOP (Structural Classification of Proteins)2HZP    3E9K   
CATH (Classification of proteins structures)2HZP    3E9K   
SuperfamilyQ16719
Human Protein AtlasENSG00000115919
Peptide AtlasQ16719
HPRD08940
IPIIPI00003818   IPI00651624   IPI00916732   IPI00915775   
Protein Interaction databases
DIP (DOE-UCLA)Q16719
IntAct (EBI)Q16719
FunCoupENSG00000115919
BioGRIDKYNU
STRING (EMBL)KYNU
ZODIACKYNU
Ontologies - Pathways
QuickGOQ16719
Ontology : AmiGOmitochondrion  cytosol  cytosol  tryptophan catabolic process  tryptophan catabolic process  NAD biosynthetic process  tryptophan catabolic process to kynurenine  tryptophan catabolic process to acetyl-CoA  quinolinate biosynthetic process  pyridoxal phosphate binding  kynureninase activity  kynureninase activity  kynureninase activity  response to interferon-gamma  response to vitamin B6  protein homodimerization activity  anthranilate metabolic process  L-kynurenine catabolic process  
Ontology : EGO-EBImitochondrion  cytosol  cytosol  tryptophan catabolic process  tryptophan catabolic process  NAD biosynthetic process  tryptophan catabolic process to kynurenine  tryptophan catabolic process to acetyl-CoA  quinolinate biosynthetic process  pyridoxal phosphate binding  kynureninase activity  kynureninase activity  kynureninase activity  response to interferon-gamma  response to vitamin B6  protein homodimerization activity  anthranilate metabolic process  L-kynurenine catabolic process  
Pathways : KEGGTryptophan metabolism   
NDEx NetworkKYNU
Atlas of Cancer Signalling NetworkKYNU
Wikipedia pathwaysKYNU
Orthology - Evolution
OrthoDB8942
GeneTree (enSembl)ENSG00000115919
Phylogenetic Trees/Animal Genes : TreeFamKYNU
HOVERGENQ16719
HOGENOMQ16719
Homologs : HomoloGeneKYNU
Homology/Alignments : Family Browser (UCSC)KYNU
Gene fusions - Rearrangements
Fusion: TCGAPBRM1 KYNU
Fusion: TCGAARHGAP15 KYNU
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKYNU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KYNU
dbVarKYNU
ClinVarKYNU
1000_GenomesKYNU 
Exome Variant ServerKYNU
ExAC (Exome Aggregation Consortium)KYNU (select the gene name)
Genetic variants : HAPMAP8942
Genomic Variants (DGV)KYNU [DGVbeta]
DECIPHERKYNU [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKYNU 
Mutations
ICGC Data PortalKYNU 
TCGA Data PortalKYNU 
Broad Tumor PortalKYNU
OASIS PortalKYNU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKYNU  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKYNU
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch KYNU
DgiDB (Drug Gene Interaction Database)KYNU
DoCM (Curated mutations)KYNU (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KYNU (select a term)
intoGenKYNU
Cancer3DKYNU(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM236800    605197   
Orphanet11181   
MedgenKYNU
Genetic Testing Registry KYNU
NextProtQ16719 [Medical]
TSGene8942
GENETestsKYNU
Target ValidationKYNU
Huge Navigator KYNU [HugePedia]
snp3D : Map Gene to Disease8942
BioCentury BCIQKYNU
ClinGenKYNU
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8942
Chemical/Pharm GKB GenePA30258
Clinical trialKYNU
Miscellaneous
canSAR (ICR)KYNU (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKYNU
EVEXKYNU
GoPubMedKYNU
iHOPKYNU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:18:56 CEST 2017

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