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KYNU (kynureninase)

Identity

Alias (NCBI)KYNUU
VCRL2
HGNC (Hugo) KYNU
HGNC Alias nameL-kynurenine hydrolase
HGNC Previous namekynureninase (L-kynurenine hydrolase)
LocusID (NCBI) 8942
Atlas_Id 65151
Location 2q22.2  [Link to chromosome band 2q22]
Location_base_pair Starts at 142877664 and ends at 143055833 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP15 (2q22.2) / KYNU (2q22.2)HTN1 (4q13.3) / KYNU (2q22.2)KYNU (2q22.2) / KYNU (2q22.2)
KYNU (2q22.2) / PAIP1 (5p12)PBRM1 (3p21.1) / KYNU (2q22.2)TGOLN2 (2p11.2) / KYNU (2q22.2)
PBRM1 KYNUARHGAP15 KYNU

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KYNU   6469
Cards
Entrez_Gene (NCBI)KYNU    kynureninase
AliasesKYNUU; VCRL2
GeneCards (Weizmann)KYNU
Ensembl hg19 (Hinxton)ENSG00000115919 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115919 [Gene_View]  ENSG00000115919 [Sequence]  chr2:142877664-143055833 [Contig_View]  KYNU [Vega]
ICGC DataPortalENSG00000115919
TCGA cBioPortalKYNU
AceView (NCBI)KYNU
Genatlas (Paris)KYNU
SOURCE (Princeton)KYNU
Genetics Home Reference (NIH)KYNU
Genomic and cartography
GoldenPath hg38 (UCSC)KYNU  -     chr2:142877664-143055833 +  2q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KYNU  -     2q22.2   [Description]    (hg19-Feb_2009)
GoldenPathKYNU - 2q22.2 [CytoView hg19]  KYNU - 2q22.2 [CytoView hg38]
ImmunoBaseENSG00000115919
Genome Data Viewer NCBIKYNU [Mapview hg19]  
OMIM236800   605197   617661   
Gene and transcription
Genbank (Entrez)AK223426 AK290900 AK292095 AK315343 AL548658
RefSeq transcript (Entrez)NM_001032998 NM_001199241 NM_003937
Consensus coding sequences : CCDS (NCBI)KYNU
Gene ExpressionKYNU [ NCBI-GEO ]   KYNU [ EBI - ARRAY_EXPRESS ]   KYNU [ SEEK ]   KYNU [ MEM ]
Gene Expression Viewer (FireBrowse)KYNU [ Firebrowse - Broad ]
GenevisibleExpression of KYNU in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8942
GTEX Portal (Tissue expression)KYNU
Human Protein AtlasENSG00000115919-KYNU [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16719   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16719  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16719
PhosPhoSitePlusQ16719
Domains : Interpro (EBI)Aminotrans_V_dom    Kynureninase    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_dom1    PyrdxlP-dep_Trfase_major   
Domain families : Pfam (Sanger)Aminotran_5 (PF00266)   
Domain families : Pfam (NCBI)pfam00266   
Conserved Domain (NCBI)KYNU
PDB (RSDB)2HZP    3E9K   
PDB Europe2HZP    3E9K   
PDB (PDBSum)2HZP    3E9K   
PDB (IMB)2HZP    3E9K   
Structural Biology KnowledgeBase2HZP    3E9K   
SCOP (Structural Classification of Proteins)2HZP    3E9K   
CATH (Classification of proteins structures)2HZP    3E9K   
SuperfamilyQ16719
AlphaFold pdb e-kbQ16719   
Human Protein Atlas [tissue]ENSG00000115919-KYNU [tissue]
HPRD08940
Protein Interaction databases
DIP (DOE-UCLA)Q16719
IntAct (EBI)Q16719
BioGRIDKYNU
STRING (EMBL)KYNU
ZODIACKYNU
Ontologies - Pathways
QuickGOQ16719
Ontology : AmiGOnucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  tryptophan catabolic process  tryptophan catabolic process  aging  NAD biosynthetic process  tryptophan catabolic process to kynurenine  tryptophan catabolic process to acetyl-CoA  quinolinate biosynthetic process  pyridoxal phosphate binding  kynureninase activity  kynureninase activity  kynureninase activity  response to interferon-gamma  'de novo' NAD biosynthetic process from tryptophan  response to vitamin B6  protein homodimerization activity  anthranilate metabolic process  anthranilate metabolic process  3-hydroxykynureninase activity  L-kynurenine catabolic process  
Ontology : EGO-EBInucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  tryptophan catabolic process  tryptophan catabolic process  aging  NAD biosynthetic process  tryptophan catabolic process to kynurenine  tryptophan catabolic process to acetyl-CoA  quinolinate biosynthetic process  pyridoxal phosphate binding  kynureninase activity  kynureninase activity  kynureninase activity  response to interferon-gamma  'de novo' NAD biosynthetic process from tryptophan  response to vitamin B6  protein homodimerization activity  anthranilate metabolic process  anthranilate metabolic process  3-hydroxykynureninase activity  L-kynurenine catabolic process  
Pathways : KEGGTryptophan metabolism   
NDEx NetworkKYNU
Atlas of Cancer Signalling NetworkKYNU
Wikipedia pathwaysKYNU
Orthology - Evolution
OrthoDB8942
GeneTree (enSembl)ENSG00000115919
Phylogenetic Trees/Animal Genes : TreeFamKYNU
Homologs : HomoloGeneKYNU
Homology/Alignments : Family Browser (UCSC)KYNU
Gene fusions - Rearrangements
Fusion : QuiverKYNU
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKYNU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KYNU
dbVarKYNU
ClinVarKYNU
MonarchKYNU
1000_GenomesKYNU 
Exome Variant ServerKYNU
GNOMAD BrowserENSG00000115919
Varsome BrowserKYNU
ACMGKYNU variants
VarityQ16719
Genomic Variants (DGV)KYNU [DGVbeta]
DECIPHERKYNU [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKYNU 
Mutations
ICGC Data PortalKYNU 
TCGA Data PortalKYNU 
Broad Tumor PortalKYNU
OASIS PortalKYNU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKYNU  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKYNU
Mutations and Diseases : HGMDKYNU
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKYNU
DgiDB (Drug Gene Interaction Database)KYNU
DoCM (Curated mutations)KYNU
CIViC (Clinical Interpretations of Variants in Cancer)KYNU
Cancer3DKYNU
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM236800    605197    617661   
Orphanet11181   
DisGeNETKYNU
MedgenKYNU
Genetic Testing Registry KYNU
NextProtQ16719 [Medical]
GENETestsKYNU
Target ValidationKYNU
Huge Navigator KYNU [HugePedia]
ClinGenKYNU
Clinical trials, drugs, therapy
MyCancerGenomeKYNU
Protein Interactions : CTDKYNU
Pharm GKB GenePA30258
PharosQ16719
Clinical trialKYNU
Miscellaneous
canSAR (ICR)KYNU
HarmonizomeKYNU
DataMed IndexKYNU
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKYNU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:55:21 CEST 2021

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