L1TD1 (LINE1 type transposase domain containing 1)

2012-03-01  

Identity

HGNC
LOCATION
1p31.3
LOCUSID
ALIAS
ECAT11

Other Information

Locus ID:

NCBI: 54596
HGNC: 25595
Ensembl: ENSG00000240563

Variants:

dbSNP: 54596
ClinVar: 54596
TCGA: ENSG00000240563
COSMIC: L1TD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000240563ENST00000498273Q5T7N2

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

References

Pubmed IDYearTitleCitations
214459762012LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese.44
221623962012RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation.33
231793652013LINE-1 hypomethylation in gastric cancer, detected by bisulfite pyrosequencing, is associated with poor prognosis.29
188429962008LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis.22
215594062011L1TD1 is a marker for undifferentiated human embryonic stem cells.13
299592192018RNase H2, mutated in Aicardi-Goutières syndrome, promotes LINE-1 retrotransposition.13
252110132014Positive selection and multiple losses of the LINE-1-derived L1TD1 gene in mammals suggest a dual role in genome defense and pluripotency.8
257026382015The L1TD1 protein interactome reveals the importance of post-transcriptional regulation in human pluripotency.8
295251832018LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways.6
261592302015Embryonic Stem Cell-Related Protein L1TD1 Is Required for Cell Viability, Neurosphere Formation, and Chemoresistance in Medulloblastoma.5

Citation

Dessen P

L1TD1 (LINE1 type transposase domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52622/l1td1