LAG3 (lymphocyte-activation gene 3)

Identity

Other names	CD223
HGNC	LAG3
Location	12p13.32
Location_base_pair	Starts at 6751931 and ends at 6757882 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	LAG3   6476
Entrez_Gene	LAG3  3902  lymphocyte-activation gene 3
	Cards
GeneCards	LAG3
Ensembl	LAG3 [Search_View]   ENSG00000089692 [Gene_View]
Genatlas	LAG3
GeneLynx	LAG3
eGenome	LAG3
euGene	3902
	Genomic and cartography
GoldenPath	LAG3  -  12p13.32   chr12:6751931-6757882 +  12p13.31   [Description]    (hg18-March_2006)
Ensembl	LAG3 - 12p13.31 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	LAG3
	Gene and transcription
Genbank	A21353 [ ENTREZ ]
Genbank	AA687676 [ ENTREZ ]
Genbank	AI274900 [ ENTREZ ]
Genbank	AK292104 [ ENTREZ ]
Genbank	BC037962 [ ENTREZ ]
RefSeq	NM_002286 [ SRS ]    NM_002286 [ ENTREZ ]
RefSeq	AC_000055 [ SRS ]    AC_000055 [ ENTREZ ]
RefSeq	AC_000144 [ SRS ]    AC_000144 [ ENTREZ ]
RefSeq	NC_000012 [ SRS ]    NC_000012 [ ENTREZ ]
RefSeq	NT_009759 [ SRS ]    NT_009759 [ ENTREZ ]
RefSeq	NW_001838050 [ SRS ]    NW_001838050 [ ENTREZ ]
RefSeq	NW_925295 [ SRS ]    NW_925295 [ ENTREZ ]
AceView	LAG3 AceView - NCBI
Unigene	Hs.409523 [ SRS ]    Hs.409523 [ NCBI ]     HS409523 [ spliceNest ]
Fast-db	1306 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P18627 [ SRS]    P18627 [ EXPASY ]     P18627 [ INTERPRO ]     P18627 [ UNIPROT ]
Prosite	PS50835 IG_LIKE [ SRS ]    PS50835 IG_LIKE [ Expasy ]
Interpro	IPR013151 Ig [ SRS ]    IPR013151 Ig [ EBI ]
Interpro	IPR007110 Ig-like [ SRS ]    IPR007110 Ig-like [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
Interpro	IPR003599 Ig_sub [ SRS ]    IPR003599 Ig_sub [ EBI ]
Interpro	IPR013106 Ig_V-set [ SRS ]    IPR013106 Ig_V-set [ EBI ]
Interpro	IPR015621 IL1-receptor [ SRS ]    IPR015621 IL1-receptor [ EBI ]
CluSTr	P18627
Pfam	PF00047 ig [ SRS ]    PF00047 ig [ Sanger ]    pfam00047 [ NCBI-CDD ]
Pfam	PF07686 V-set [ SRS ]    PF07686 V-set [ Sanger ]    pfam07686 [ NCBI-CDD ]
Smart	SM00409 IG [EMBL]
Blocks	P18627
HPRD	01077
	Protein Interaction databases
DIP	P18627
IntAct	P18627
	Polymorphism : SNP, mutations, diseases
OMIM	153337    [ map ]
GENECLINICS	153337
SNP	LAG3 [dbSNP-NCBI]
SNP	NM_002286 [SNP-NCI]
SNP	LAG3 [GeneSNPs - Utah]  LAG3] [HGBASE - SRS]
HAPMAP	LAG3 [HAPMAP]
HGMD	LAG3
	General knowledge
Family Browser	LAG3 [UCSC Family Browser]
SOURCE	NM_002286
SMD	Hs.409523
SAGE	Hs.409523
GO	antigen binding [Amigo]  antigen binding
GO	transmembrane receptor activity [Amigo]  transmembrane receptor activity
GO	cell surface receptor linked signal transduction [Amigo]  cell surface receptor linked signal transduction
GO	external side of plasma membrane [Amigo]  external side of plasma membrane
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	MHC class II protein binding [Amigo]  MHC class II protein binding
GO	negative regulation of interleukin-2 biosynthetic process [Amigo]  negative regulation of interleukin-2 biosynthetic process
GO	positive regulation of natural killer cell mediated cytotoxicity [Amigo]  positive regulation of natural killer cell mediated cytotoxicity
GO	negative regulation of T cell activation [Amigo]  negative regulation of T cell activation
PubGene	LAG3
TreeFam	LAG3
CTD	3902 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	LAG3 Related clones (RZPD - Berlin)
	PubMed
PubMed	19 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:48:11 2008