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LAMA1 (laminin subunit alpha 1)

Identity

Alias_namesLAMA
laminin
Other aliasPTBHS
S-LAM-alpha
HGNC (Hugo) LAMA1
LocusID (NCBI) 284217
Atlas_Id 51060
Location 18p11.31  [Link to chromosome band 18p11]
Location_base_pair Starts at 6941744 and ends at 7117814 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APOC1 (19q13.32) / LAMA1 (18p11.31)EPB41L3 (18p11.31) / LAMA1 (18p11.31)L3MBTL4 (18p11.31) / LAMA1 (18p11.31)
EPB41L3 18p11.31 / LAMA1 18p11.31L3MBTL4 18p11.31 / LAMA1 18p11.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LAMA1   6481
Cards
Entrez_Gene (NCBI)LAMA1  284217  laminin subunit alpha 1
AliasesLAMA; PTBHS; S-LAM-alpha
GeneCards (Weizmann)LAMA1
Ensembl hg19 (Hinxton)ENSG00000101680 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101680 [Gene_View]  chr18:6941744-7117814 [Contig_View]  LAMA1 [Vega]
ICGC DataPortalENSG00000101680
TCGA cBioPortalLAMA1
AceView (NCBI)LAMA1
Genatlas (Paris)LAMA1
WikiGenes284217
SOURCE (Princeton)LAMA1
Genetics Home Reference (NIH)LAMA1
Genomic and cartography
GoldenPath hg38 (UCSC)LAMA1  -     chr18:6941744-7117814 -  18p11.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAMA1  -     18p11.31   [Description]    (hg19-Feb_2009)
EnsemblLAMA1 - 18p11.31 [CytoView hg19]  LAMA1 - 18p11.31 [CytoView hg38]
Mapping of homologs : NCBILAMA1 [Mapview hg19]  LAMA1 [Mapview hg38]
OMIM150320   615960   
Gene and transcription
Genbank (Entrez)AF351616 AK091949 AK093376 BC016997 BC032758
RefSeq transcript (Entrez)NM_005559
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LAMA1
Cluster EST : UnigeneHs.270364 [ NCBI ]
CGAP (NCI)Hs.270364
Alternative Splicing GalleryENSG00000101680
Gene ExpressionLAMA1 [ NCBI-GEO ]   LAMA1 [ EBI - ARRAY_EXPRESS ]   LAMA1 [ SEEK ]   LAMA1 [ MEM ]
Gene Expression Viewer (FireBrowse)LAMA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)284217
GTEX Portal (Tissue expression)LAMA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25391   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25391  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25391
Splice isoforms : SwissVarP25391
PhosPhoSitePlusP25391
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    LAM_G_DOMAIN (PS50025)    LAMININ_IVA (PS51115)    LAMININ_NTER (PS51117)   
Domains : Interpro (EBI)ConA-like_dom    EGF-like_dom    Laminin_aI    Laminin_domII    Laminin_EGF    Laminin_G    Laminin_IV    Laminin_N   
Domain families : Pfam (Sanger)Laminin_B (PF00052)    Laminin_EGF (PF00053)    Laminin_G_1 (PF00054)    Laminin_I (PF06008)    Laminin_II (PF06009)    Laminin_N (PF00055)   
Domain families : Pfam (NCBI)pfam00052    pfam00053    pfam00054    pfam06008    pfam06009    pfam00055   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_Lam (SM00180)  LamB (SM00281)  LamG (SM00282)  LamNT (SM00136)  
Conserved Domain (NCBI)LAMA1
DMDM Disease mutations284217
Blocks (Seattle)LAMA1
SuperfamilyP25391
Human Protein AtlasENSG00000101680
Peptide AtlasP25391
HPRD01033
IPIIPI00375294   IPI00902604   IPI00783661   
Protein Interaction databases
DIP (DOE-UCLA)P25391
IntAct (EBI)P25391
FunCoupENSG00000101680
BioGRIDLAMA1
STRING (EMBL)LAMA1
ZODIACLAMA1
Ontologies - Pathways
QuickGOP25391
Ontology : AmiGOreceptor binding  extracellular matrix structural constituent  protein binding  extracellular region  proteinaceous extracellular matrix  basement membrane  laminin-1 complex  laminin-1 complex  laminin-3 complex  extracellular space  cell adhesion  cell surface receptor signaling pathway  protein C-terminus binding  membrane  regulation of cell adhesion  extracellular matrix organization  regulation of cell migration  extracellular matrix  extracellular matrix  regulation of embryonic development  
Ontology : EGO-EBIreceptor binding  extracellular matrix structural constituent  protein binding  extracellular region  proteinaceous extracellular matrix  basement membrane  laminin-1 complex  laminin-1 complex  laminin-3 complex  extracellular space  cell adhesion  cell surface receptor signaling pathway  protein C-terminus binding  membrane  regulation of cell adhesion  extracellular matrix organization  regulation of cell migration  extracellular matrix  extracellular matrix  regulation of embryonic development  
Pathways : BIOCARTAPrion Pathway [Genes]   
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Toxoplasmosis    Amoebiasis    Pathways in cancer    Small cell lung cancer   
NDEx NetworkLAMA1
Atlas of Cancer Signalling NetworkLAMA1
Wikipedia pathwaysLAMA1
Orthology - Evolution
OrthoDB284217
GeneTree (enSembl)ENSG00000101680
Phylogenetic Trees/Animal Genes : TreeFamLAMA1
HOVERGENP25391
HOGENOMP25391
Homologs : HomoloGeneLAMA1
Homology/Alignments : Family Browser (UCSC)LAMA1
Gene fusions - Rearrangements
Fusion : MitelmanEPB41L3/LAMA1 [18p11.31/18p11.31]  [t(18;18)(p11;p11)]  
Fusion : MitelmanL3MBTL4/LAMA1 [18p11.31/18p11.31]  [t(18;18)(p11;p11)]  
Fusion: TCGAEPB41L3 18p11.31 LAMA1 18p11.31 BRCA
Fusion: TCGAL3MBTL4 18p11.31 LAMA1 18p11.31 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAMA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMA1
dbVarLAMA1
ClinVarLAMA1
1000_GenomesLAMA1 
Exome Variant ServerLAMA1
ExAC (Exome Aggregation Consortium)LAMA1 (select the gene name)
Genetic variants : HAPMAP284217
Genomic Variants (DGV)LAMA1 [DGVbeta]
DECIPHERLAMA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAMA1 
Mutations
ICGC Data PortalLAMA1 
TCGA Data PortalLAMA1 
Broad Tumor PortalLAMA1
OASIS PortalLAMA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAMA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLAMA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAMA1
DgiDB (Drug Gene Interaction Database)LAMA1
DoCM (Curated mutations)LAMA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAMA1 (select a term)
intoGenLAMA1
Cancer3DLAMA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM150320    615960   
Orphanet22466   
MedgenLAMA1
Genetic Testing Registry LAMA1
NextProtP25391 [Medical]
TSGene284217
GENETestsLAMA1
Target ValidationLAMA1
Huge Navigator LAMA1 [HugePedia]
snp3D : Map Gene to Disease284217
BioCentury BCIQLAMA1
ClinGenLAMA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD284217
Chemical/Pharm GKB GenePA30270
Clinical trialLAMA1
Miscellaneous
canSAR (ICR)LAMA1 (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAMA1
EVEXLAMA1
GoPubMedLAMA1
iHOPLAMA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:05:01 CEST 2017

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