LAMA1 (laminin subunit alpha 1)

2009-09-01  

Identity

HGNC
LOCATION
18p11.31
LOCUSID
ALIAS
LAMA,PTBHS,S-LAM-alpha
FUSION GENES

Other Information

Locus ID:

NCBI: 284217
MIM: 150320
HGNC: 6481
Ensembl: ENSG00000101680

Variants:

dbSNP: 284217
ClinVar: 284217
TCGA: ENSG00000101680
COSMIC: LAMA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101680ENST00000389658P25391
ENSG00000101680ENST00000638611A0A1W2PQN4

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Small cell lung cancerKEGGko05222
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Signal TransductionREACTOMER-HSA-162582
Extracellular matrix organizationREACTOMER-HSA-1474244
Laminin interactionsREACTOMER-HSA-3000157
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
ECM proteoglycansREACTOMER-HSA-3000178
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET activates PTK2 signalingREACTOMER-HSA-8874081

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
226934552012Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.83
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
194168972009Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy.58
195872352009Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase.45
228403902012Unique preservation of neural cells in Hutchinson- Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA.44
184368682008CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and alpha6 integrin expression.37
123937392003Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.30
229190692012The extracellular matrix is a novel attribute of endothelial progenitors and of hypoxic mature endothelial cells.24

Citation

Dessen P

LAMA1 (laminin subunit alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51060/lama1