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LAMA2 (laminin, alpha 2)

Identity

Other namesLAMM
HGNC (Hugo) LAMA2
LocusID (NCBI) 3908
Location 6q22.33
Location_base_pair Starts at 129204286 and ends at 129837710 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)LAMA2   6482
Cards
Entrez_Gene (NCBI)LAMA2  3908  laminin, alpha 2
GeneCards (Weizmann)LAMA2
Ensembl hg19 (Hinxton)ENSG00000196569 [Gene_View]  chr6:129204286-129837710 [Contig_View]  LAMA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196569 [Gene_View]  chr6:129204286-129837710 [Contig_View]  LAMA2 [Vega]
ICGC DataPortalENSG00000196569
cBioPortalLAMA2
AceView (NCBI)LAMA2
Genatlas (Paris)LAMA2
WikiGenes3908
SOURCE (Princeton)LAMA2
Genomic and cartography
GoldenPath hg19 (UCSC)LAMA2  -     chr6:129204286-129837710 +  6q22.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LAMA2  -     6q22.33   [Description]    (hg38-Dec_2013)
EnsemblLAMA2 - 6q22.33 [CytoView hg19]  LAMA2 - 6q22.33 [CytoView hg38]
Mapping of homologs : NCBILAMA2 [Mapview hg19]  LAMA2 [Mapview hg38]
OMIM156225   607855   
Gene and transcription
Genbank (Entrez)AB208922 AK026829 AL041786 BC172257 BC172564
RefSeq transcript (Entrez)NM_000426 NM_001079823
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_008678 NT_025741 NW_001838990 NW_004929328
Consensus coding sequences : CCDS (NCBI)LAMA2
Cluster EST : UnigeneHs.200841 [ NCBI ]
CGAP (NCI)Hs.200841
Alternative Splicing : Fast-db (Paris)GSHG0026029
Alternative Splicing GalleryENSG00000196569
Gene ExpressionLAMA2 [ NCBI-GEO ]     LAMA2 [ SEEK ]   LAMA2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24043 (Uniprot)
NextProtP24043  [Medical]
With graphics : InterProP24043
Splice isoforms : SwissVarP24043 (Swissvar)
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    LAM_G_DOMAIN (PS50025)    LAMININ_IVA (PS51115)    LAMININ_NTER (PS51117)   
Domains : Interpro (EBI)ConA-like_lec_gl_sf    ConA-like_subgrp    EGF_laminin    Galactose-bd-like    Laminin_B_subgr    Laminin_B_type_IV    Laminin_G    Laminin_I    Laminin_II    Laminin_N   
Related proteins : CluSTrP24043
Domain families : Pfam (Sanger)Laminin_B (PF00052)    Laminin_EGF (PF00053)    Laminin_G_1 (PF00054)    Laminin_G_2 (PF02210)    Laminin_I (PF06008)    Laminin_II (PF06009)    Laminin_N (PF00055)   
Domain families : Pfam (NCBI)pfam00052    pfam00053    pfam00054    pfam02210    pfam06008    pfam06009    pfam00055   
Domain families : Smart (EMBL)EGF_Lam (SM00180)  LamB (SM00281)  LamG (SM00282)  LamNT (SM00136)  
DMDM Disease mutations3908
Blocks (Seattle)P24043
Human Protein AtlasENSG00000196569
Peptide AtlasP24043
HPRD01125
IPIIPI00873889   IPI00479834   IPI00940615   IPI01014296   IPI00218725   
Protein Interaction databases
DIP (DOE-UCLA)P24043
IntAct (EBI)P24043
FunCoupENSG00000196569
BioGRIDLAMA2
IntegromeDBLAMA2
STRING (EMBL)LAMA2
Ontologies - Pathways
QuickGOP24043
Ontology : AmiGOreceptor binding  structural molecule activity  extracellular region  basement membrane  laminin-1 complex  cell adhesion  axon guidance  muscle organ development  myelination in peripheral nervous system  regulation of cell adhesion  extracellular matrix organization  regulation of cell migration  extracellular matrix  positive regulation of synaptic transmission, cholinergic  sarcolemma  dendritic spine  regulation of embryonic development  extracellular vesicular exosome  
Ontology : EGO-EBIreceptor binding  structural molecule activity  extracellular region  basement membrane  laminin-1 complex  cell adhesion  axon guidance  muscle organ development  myelination in peripheral nervous system  regulation of cell adhesion  extracellular matrix organization  regulation of cell migration  extracellular matrix  positive regulation of synaptic transmission, cholinergic  sarcolemma  dendritic spine  regulation of embryonic development  extracellular vesicular exosome  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Toxoplasmosis    Amoebiasis    Pathways in cancer    Small cell lung cancer    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy    Viral myocarditis   
Protein Interaction DatabaseLAMA2
DoCM (Curated mutations)LAMA2
Wikipedia pathwaysLAMA2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLAMA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMA2
dbVarLAMA2
ClinVarLAMA2
1000_GenomesLAMA2 
Exome Variant ServerLAMA2
SNP (GeneSNP Utah)LAMA2
SNP : HGBaseLAMA2
Genetic variants : HAPMAPLAMA2
Genomic VariantsLAMA2  LAMA2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000196569 
Somatic Mutations in Cancer : COSMICLAMA2 
CONAN: Copy Number AnalysisLAMA2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:129204286-129837710
Mutations and Diseases : HGMDLAMA2
OMIM156225    607855   
MedgenLAMA2
NextProtP24043 [Medical]
GENETestsLAMA2
Disease Genetic AssociationLAMA2
Huge Navigator LAMA2 [HugePedia]  LAMA2 [HugeCancerGEM]
snp3D : Map Gene to Disease3908
DGIdb (Drug Gene Interaction db)LAMA2
General knowledge
Homologs : HomoloGeneLAMA2
Homology/Alignments : Family Browser (UCSC)LAMA2
Phylogenetic Trees/Animal Genes : TreeFamLAMA2
Chemical/Protein Interactions : CTD3908
Chemical/Pharm GKB GenePA30271
Clinical trialLAMA2
Cancer Resource (Charite)ENSG00000196569
Other databases
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
CoreMineLAMA2
GoPubMedLAMA2
iHOPLAMA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:24:45 CET 2014

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