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LAMA3 (laminin, alpha 3)

Identity

Other namesBM600
E170
LAMNA
LOCS
HGNC (Hugo) LAMA3
LocusID (NCBI) 3909
Atlas_Id 45590
Location 18q11.2
Location_base_pair Starts at 21452984 and ends at 21535029 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)LAMA3   6483
Cards
Entrez_Gene (NCBI)LAMA3  3909  laminin, alpha 3
GeneCards (Weizmann)LAMA3
Ensembl hg19 (Hinxton)ENSG00000053747 [Gene_View]  chr18:21452984-21535029 [Contig_View]  LAMA3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000053747 [Gene_View]  chr18:21452984-21535029 [Contig_View]  LAMA3 [Vega]
ICGC DataPortalENSG00000053747
TCGA cBioPortalLAMA3
AceView (NCBI)LAMA3
Genatlas (Paris)LAMA3
WikiGenes3909
SOURCE (Princeton)LAMA3
Genomic and cartography
GoldenPath hg19 (UCSC)LAMA3  -     chr18:21452984-21535029 +  18q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LAMA3  -     18q11.2   [Description]    (hg38-Dec_2013)
EnsemblLAMA3 - 18q11.2 [CytoView hg19]  LAMA3 - 18q11.2 [CytoView hg38]
Mapping of homologs : NCBILAMA3 [Mapview hg19]  LAMA3 [Mapview hg38]
OMIM226650   226700   245660   600805   
Gene and transcription
Genbank (Entrez)AA001432 AB107369 AB208853 AF005258 AI125611
RefSeq transcript (Entrez)NM_000227 NM_001127717 NM_001127718 NM_001302996 NM_198129
RefSeq genomic (Entrez)NC_000018 NC_018929 NG_007853 NT_010966 NW_004929410
Consensus coding sequences : CCDS (NCBI)LAMA3
Cluster EST : UnigeneHs.436367 [ NCBI ]
CGAP (NCI)Hs.436367
Alternative Splicing : Fast-db (Paris)GSHG0013964
Alternative Splicing GalleryENSG00000053747
Gene ExpressionLAMA3 [ NCBI-GEO ]     LAMA3 [ SEEK ]   LAMA3 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16787 (Uniprot)
NextProtQ16787  [Medical]
With graphics : InterProQ16787
Splice isoforms : SwissVarQ16787 (Swissvar)
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    LAM_G_DOMAIN (PS50025)    LAMININ_IVA (PS51115)    LAMININ_NTER (PS51117)   
Domains : Interpro (EBI)ConA-like_dom    EGF-like_CS    EGF_laminin    Laminin_B_subgr    Laminin_B_type_IV    Laminin_domII    Laminin_G    Laminin_I    Laminin_N   
Related proteins : CluSTrQ16787
Domain families : Pfam (Sanger)Laminin_B (PF00052)    Laminin_EGF (PF00053)    Laminin_G_1 (PF00054)    Laminin_G_2 (PF02210)    Laminin_I (PF06008)    Laminin_II (PF06009)    Laminin_N (PF00055)   
Domain families : Pfam (NCBI)pfam00052    pfam00053    pfam00054    pfam02210    pfam06008    pfam06009    pfam00055   
Domain families : Smart (EMBL)EGF_Lam (SM00180)  LamB (SM00281)  LamG (SM00282)  LamNT (SM00136)  
DMDM Disease mutations3909
Blocks (Seattle)Q16787
Human Protein AtlasENSG00000053747
Peptide AtlasQ16787
HPRD02883
IPIIPI00377045   IPI01012763   IPI01011933   IPI01018132   IPI00743994   IPI00895830   IPI00790908   
Protein Interaction databases
DIP (DOE-UCLA)Q16787
IntAct (EBI)Q16787
FunCoupENSG00000053747
BioGRIDLAMA3
IntegromeDBLAMA3
STRING (EMBL)LAMA3
Ontologies - Pathways
QuickGOQ16787
Ontology : AmiGOreceptor binding  structural molecule activity  extracellular region  basement membrane  laminin-1 complex  laminin-5 complex  cell adhesion  epidermis development  extracellular matrix disassembly  regulation of cell adhesion  extracellular matrix organization  regulation of cell migration  hemidesmosome assembly  cell junction assembly  endodermal cell differentiation  regulation of embryonic development  extracellular exosome  
Ontology : EGO-EBIreceptor binding  structural molecule activity  extracellular region  basement membrane  laminin-1 complex  laminin-5 complex  cell adhesion  epidermis development  extracellular matrix disassembly  regulation of cell adhesion  extracellular matrix organization  regulation of cell migration  hemidesmosome assembly  cell junction assembly  endodermal cell differentiation  regulation of embryonic development  extracellular exosome  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Toxoplasmosis    Amoebiasis    Pathways in cancer    Small cell lung cancer   
Protein Interaction DatabaseLAMA3
DoCM (Curated mutations)LAMA3
Wikipedia pathwaysLAMA3
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerLAMA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMA3
dbVarLAMA3
ClinVarLAMA3
1000_GenomesLAMA3 
Exome Variant ServerLAMA3
SNP (GeneSNP Utah)LAMA3
SNP : HGBaseLAMA3
Genetic variants : HAPMAPLAMA3
Genomic Variants (DGV)LAMA3 [DGVbeta]
Mutations
ICGC Data PortalLAMA3 
TCGA Data PortalLAMA3 
Tumor PortalLAMA3
Somatic Mutations in Cancer : COSMICLAMA3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)18:21452984-21535029
CONAN: Copy Number AnalysisLAMA3 
Mutations and Diseases : HGMDLAMA3
OMIM226650    226700    245660    600805   
MedgenLAMA3
NextProtQ16787 [Medical]
GENETestsLAMA3
Disease Genetic AssociationLAMA3
Huge Navigator LAMA3 [HugePedia]  LAMA3 [HugeCancerGEM]
snp3D : Map Gene to Disease3909
DGIdb (Drug Gene Interaction db)LAMA3
General knowledge
Homologs : HomoloGeneLAMA3
Homology/Alignments : Family Browser (UCSC)LAMA3
Phylogenetic Trees/Animal Genes : TreeFamLAMA3
Chemical/Protein Interactions : CTD3909
Chemical/Pharm GKB GenePA30272
Clinical trialLAMA3
Cancer Resource (Charite)ENSG00000053747
Other databases
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
CoreMineLAMA3
GoPubMedLAMA3
iHOPLAMA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:40:25 CEST 2015

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