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LAMA3 (laminin subunit alpha 3)

Identity

Other namesBM600
E170
LAMNA
LOCS
HGNC (Hugo) LAMA3
LocusID (NCBI) 3909
Atlas_Id 45590
Location 18q11.2
Location_base_pair Starts at 21452984 and ends at 21535029 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDH2 (18q12.1) / LAMA3 (18q11.2)ESCO1 (18q11.2) / LAMA3 (18q11.2)LAMA3 (18q11.2) / CABLES1 (18q11.2)
LAMA3 (18q11.2) / CARM1 (19p13.2)LAMA3 (18q11.2) / GAREM ()LAMA3 (18q11.2) / GAREM1 (18q12.1)
LAMA3 (18q11.2) / GNAL (18p11.21)LAMA3 (18q11.2) / JUP (17q21.2)LAMA3 (18q11.2) / LAMA3 (18q11.2)
LAMA3 (18q11.2) / MET (7q31.2)LAMA3 (18q11.2) / PKP1 (1q32.1)LAMA3 (18q11.2) / PLA2G1B (12q24.31)
LAMA3 (18q11.2) / PSMA8 (18q11.2)LAMA3 (18q11.2) / RBBP8 (18q11.2)LAMA3 (18q11.2) / SNAP25 (20p12.2)
LAMA3 (18q11.2) / ZNF521 (18q11.2)LPXN (11q12.1) / LAMA3 (18q11.2)TTC39C (18q11.2) / LAMA3 (18q11.2)
CDH2 18q12.1 / LAMA3 18q11.2ESCO1 18q11.2 / LAMA3 18q11.2LAMA3 18q11.2 / CABLES1 18q11.2
LAMA3 18q11.2 FAM59ALAMA3 18q11.2 / GNAL 18p11.21LAMA3 18q11.2 / PSMA8 18q11.2
LAMA3 18q11.2 / ZNF521 18q11.2TTC39C 18q11.2 / LAMA3 18q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Lung: Translocations in Adenocarcinoma

External links

Nomenclature
HGNC (Hugo)LAMA3   6483
Cards
Entrez_Gene (NCBI)LAMA3  3909  laminin subunit alpha 3
AliasesBM600; E170; LAMNA; LOCS
GeneCards (Weizmann)LAMA3
Ensembl hg19 (Hinxton)ENSG00000053747 [Gene_View]  chr18:21452984-21535029 [Contig_View]  LAMA3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000053747 [Gene_View]  chr18:21452984-21535029 [Contig_View]  LAMA3 [Vega]
ICGC DataPortalENSG00000053747
TCGA cBioPortalLAMA3
AceView (NCBI)LAMA3
Genatlas (Paris)LAMA3
WikiGenes3909
SOURCE (Princeton)LAMA3
Genomic and cartography
GoldenPath hg19 (UCSC)LAMA3  -     chr18:21452984-21535029 +  18q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LAMA3  -     18q11.2   [Description]    (hg38-Dec_2013)
EnsemblLAMA3 - 18q11.2 [CytoView hg19]  LAMA3 - 18q11.2 [CytoView hg38]
Mapping of homologs : NCBILAMA3 [Mapview hg19]  LAMA3 [Mapview hg38]
OMIM226650   226700   245660   600805   
Gene and transcription
Genbank (Entrez)AA001432 AB107369 AB208853 AF005258 AI125611
RefSeq transcript (Entrez)NM_000227 NM_001127717 NM_001127718 NM_001302996 NM_198129
RefSeq genomic (Entrez)NC_000018 NC_018929 NG_007853 NT_010966 NW_004929410
Consensus coding sequences : CCDS (NCBI)LAMA3
Cluster EST : UnigeneHs.436367 [ NCBI ]
CGAP (NCI)Hs.436367
Alternative Splicing GalleryENSG00000053747
Gene ExpressionLAMA3 [ NCBI-GEO ]   LAMA3 [ EBI - ARRAY_EXPRESS ]   LAMA3 [ SEEK ]   LAMA3 [ MEM ]
Gene Expression Viewer (FireBrowse)LAMA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3909
GTEX Portal (Tissue expression)LAMA3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16787 (Uniprot)
NextProtQ16787  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16787
Splice isoforms : SwissVarQ16787 (Swissvar)
PhosPhoSitePlusQ16787
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    LAM_G_DOMAIN (PS50025)    LAMININ_IVA (PS51115)    LAMININ_NTER (PS51117)   
Domains : Interpro (EBI)ConA-like_dom    EGF-like_CS    Laminin_aI    Laminin_domII    Laminin_EGF    Laminin_G    Laminin_IV    Laminin_N   
Domain families : Pfam (Sanger)Laminin_B (PF00052)    Laminin_EGF (PF00053)    Laminin_G_1 (PF00054)    Laminin_G_2 (PF02210)    Laminin_I (PF06008)    Laminin_II (PF06009)    Laminin_N (PF00055)   
Domain families : Pfam (NCBI)pfam00052    pfam00053    pfam00054    pfam02210    pfam06008    pfam06009    pfam00055   
Domain families : Smart (EMBL)EGF_Lam (SM00180)  LamB (SM00281)  LamG (SM00282)  LamNT (SM00136)  
DMDM Disease mutations3909
Blocks (Seattle)LAMA3
SuperfamilyQ16787
Human Protein AtlasENSG00000053747
Peptide AtlasQ16787
HPRD02883
IPIIPI00377045   IPI01012763   IPI01011933   IPI01018132   IPI00743994   IPI00895830   IPI00790908   
Protein Interaction databases
DIP (DOE-UCLA)Q16787
IntAct (EBI)Q16787
FunCoupENSG00000053747
BioGRIDLAMA3
STRING (EMBL)LAMA3
ZODIACLAMA3
Ontologies - Pathways
QuickGOQ16787
Ontology : AmiGOreceptor binding  structural molecule activity  extracellular region  basement membrane  laminin-5 complex  cell adhesion  epidermis development  extracellular matrix disassembly  regulation of cell adhesion  extracellular matrix organization  regulation of cell migration  hemidesmosome assembly  endodermal cell differentiation  regulation of embryonic development  extracellular exosome  
Ontology : EGO-EBIreceptor binding  structural molecule activity  extracellular region  basement membrane  laminin-5 complex  cell adhesion  epidermis development  extracellular matrix disassembly  regulation of cell adhesion  extracellular matrix organization  regulation of cell migration  hemidesmosome assembly  endodermal cell differentiation  regulation of embryonic development  extracellular exosome  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Toxoplasmosis    Amoebiasis    Pathways in cancer    Small cell lung cancer   
NDEx Network
Atlas of Cancer Signalling NetworkLAMA3
Wikipedia pathwaysLAMA3
Orthology - Evolution
OrthoDB3909
GeneTree (enSembl)ENSG00000053747
Phylogenetic Trees/Animal Genes : TreeFamLAMA3
Homologs : HomoloGeneLAMA3
Homology/Alignments : Family Browser (UCSC)LAMA3
Gene fusions - Rearrangements
Fusion: TCGACDH2 18q12.1 LAMA3 18q11.2 LUAD
Fusion: TCGAESCO1 18q11.2 LAMA3 18q11.2 LUSC
Fusion: TCGALAMA3 18q11.2 CABLES1 18q11.2 LUAD
Fusion: TCGALAMA3 18q11.2 FAM59A LUAD
Fusion: TCGALAMA3 18q11.2 GNAL 18p11.21 LUAD
Fusion: TCGALAMA3 18q11.2 PSMA8 18q11.2 BRCA
Fusion: TCGALAMA3 18q11.2 ZNF521 18q11.2 LUAD
Fusion: TCGATTC39C 18q11.2 LAMA3 18q11.2 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerLAMA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMA3
dbVarLAMA3
ClinVarLAMA3
1000_GenomesLAMA3 
Exome Variant ServerLAMA3
ExAC (Exome Aggregation Consortium)LAMA3 (select the gene name)
Genetic variants : HAPMAP3909
Genomic Variants (DGV)LAMA3 [DGVbeta]
Mutations
ICGC Data PortalLAMA3 
TCGA Data PortalLAMA3 
Broad Tumor PortalLAMA3
OASIS PortalLAMA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAMA3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAMA3
DgiDB (Drug Gene Interaction Database)LAMA3
DoCM (Curated mutations)LAMA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAMA3 (select a term)
intoGenLAMA3
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)18:21452984-21535029  ENSG00000053747
CONAN: Copy Number AnalysisLAMA3 
Mutations and Diseases : HGMDLAMA3
OMIM226650    226700    245660    600805   
MedgenLAMA3
Genetic Testing Registry LAMA3
NextProtQ16787 [Medical]
TSGene3909
GENETestsLAMA3
Huge Navigator LAMA3 [HugePedia]
snp3D : Map Gene to Disease3909
BioCentury BCIQLAMA3
ClinGenLAMA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3909
Chemical/Pharm GKB GenePA30272
Clinical trialLAMA3
Miscellaneous
canSAR (ICR)LAMA3 (select the gene name)
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAMA3
EVEXLAMA3
GoPubMedLAMA3
iHOPLAMA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:08:25 CEST 2016

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