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LAMA4 (laminin subunit alpha 4)

Identity

Alias_nameslaminin
Alias_symbol (synonym)LAMA3
Other aliasCMD1JJ
LAMA4*-1
HGNC (Hugo) LAMA4
LocusID (NCBI) 3910
Atlas_Id 41114
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 112107931 and ends at 112254715 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FYN (6q21) / LAMA4 (6q21)HMGA1 (6p21.31) / LAMA4 (6q21)LAMA4 (6q21) / IGFBP4 (17q21.2)
LAMA4 (6q21) / ILK (11p15.4)REV3L (6q21) / LAMA4 (6q21)RNF20 (9q31.1) / LAMA4 (6q21)
VIM (10p13) / LAMA4 (6q21)FYN 6q21 / LAMA4 6q21REV3L 6q21 / LAMA4 6q21
VIM 10p13 / LAMA4 6q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  inv(6)(p21q21) HMGA1/LAMA4


External links

Nomenclature
HGNC (Hugo)LAMA4   6484
LRG (Locus Reference Genomic)LRG_433
Cards
Entrez_Gene (NCBI)LAMA4  3910  laminin subunit alpha 4
AliasesCMD1JJ; LAMA3; LAMA4*-1
GeneCards (Weizmann)LAMA4
Ensembl hg19 (Hinxton)ENSG00000112769 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112769 [Gene_View]  ENSG00000112769 [Sequence]  chr6:112107931-112254715 [Contig_View]  LAMA4 [Vega]
ICGC DataPortalENSG00000112769
TCGA cBioPortalLAMA4
AceView (NCBI)LAMA4
Genatlas (Paris)LAMA4
WikiGenes3910
SOURCE (Princeton)LAMA4
Genetics Home Reference (NIH)LAMA4
Genomic and cartography
GoldenPath hg38 (UCSC)LAMA4  -     chr6:112107931-112254715 -  6q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAMA4  -     6q21   [Description]    (hg19-Feb_2009)
EnsemblLAMA4 - 6q21 [CytoView hg19]  LAMA4 - 6q21 [CytoView hg38]
Mapping of homologs : NCBILAMA4 [Mapview hg19]  LAMA4 [Mapview hg38]
OMIM600133   615235   
Gene and transcription
Genbank (Entrez)AB210027 AJ710266 AK027151 AK304401 BC004241
RefSeq transcript (Entrez)NM_001105206 NM_001105207 NM_001105208 NM_001105209 NM_002290
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LAMA4
Cluster EST : UnigeneHs.654572 [ NCBI ]
CGAP (NCI)Hs.654572
Alternative Splicing GalleryENSG00000112769
Gene ExpressionLAMA4 [ NCBI-GEO ]   LAMA4 [ EBI - ARRAY_EXPRESS ]   LAMA4 [ SEEK ]   LAMA4 [ MEM ]
Gene Expression Viewer (FireBrowse)LAMA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3910
GTEX Portal (Tissue expression)LAMA4
Human Protein AtlasENSG00000112769-LAMA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16363   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16363  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16363
Splice isoforms : SwissVarQ16363
PhosPhoSitePlusQ16363
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)ConA-like_dom    EGF-like_dom    Laminin_aI    Laminin_domII    Laminin_EGF    Laminin_G   
Domain families : Pfam (Sanger)Laminin_EGF (PF00053)    Laminin_G_2 (PF02210)    Laminin_I (PF06008)    Laminin_II (PF06009)   
Domain families : Pfam (NCBI)pfam00053    pfam02210    pfam06008    pfam06009   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_Lam (SM00180)  LamG (SM00282)  
Conserved Domain (NCBI)LAMA4
DMDM Disease mutations3910
Blocks (Seattle)LAMA4
SuperfamilyQ16363
Human Protein Atlas [tissue]ENSG00000112769-LAMA4 [tissue]
Peptide AtlasQ16363
HPRD02532
IPIIPI00329482   IPI00735310   IPI00024406   IPI00552274   IPI00552942   IPI00973355   IPI01009984   IPI00981777   IPI00983822   IPI00418476   IPI00983223   
Protein Interaction databases
DIP (DOE-UCLA)Q16363
IntAct (EBI)Q16363
FunCoupENSG00000112769
BioGRIDLAMA4
STRING (EMBL)LAMA4
ZODIACLAMA4
Ontologies - Pathways
QuickGOQ16363
Ontology : AmiGOreceptor binding  extracellular matrix structural constituent  protein binding  extracellular region  basement membrane  basal lamina  cell adhesion  regulation of cell adhesion  extracellular matrix organization  regulation of cell migration  extracellular matrix  extracellular matrix  regulation of embryonic development  extracellular exosome  
Ontology : EGO-EBIreceptor binding  extracellular matrix structural constituent  protein binding  extracellular region  basement membrane  basal lamina  cell adhesion  regulation of cell adhesion  extracellular matrix organization  regulation of cell migration  extracellular matrix  extracellular matrix  regulation of embryonic development  extracellular exosome  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGCell Communication    ECM-receptor interaction    Focal adhesion   
NDEx NetworkLAMA4
Atlas of Cancer Signalling NetworkLAMA4
Wikipedia pathwaysLAMA4
Orthology - Evolution
OrthoDB3910
GeneTree (enSembl)ENSG00000112769
Phylogenetic Trees/Animal Genes : TreeFamLAMA4
HOVERGENQ16363
HOGENOMQ16363
Homologs : HomoloGeneLAMA4
Homology/Alignments : Family Browser (UCSC)LAMA4
Gene fusions - Rearrangements
Fusion : MitelmanHMGA1/LAMA4 [6p21.31/6q21]  [inv(6)(p21q21)]  
Fusion PortalFYN 6q21 LAMA4 6q21 LUAD
Fusion PortalREV3L 6q21 LAMA4 6q21 PRAD
Fusion PortalVIM 10p13 LAMA4 6q21 SKCM
Fusion : QuiverLAMA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAMA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMA4
dbVarLAMA4
ClinVarLAMA4
1000_GenomesLAMA4 
Exome Variant ServerLAMA4
ExAC (Exome Aggregation Consortium)ENSG00000112769
GNOMAD BrowserENSG00000112769
Genetic variants : HAPMAP3910
Genomic Variants (DGV)LAMA4 [DGVbeta]
DECIPHERLAMA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAMA4 
Mutations
ICGC Data PortalLAMA4 
TCGA Data PortalLAMA4 
Broad Tumor PortalLAMA4
OASIS PortalLAMA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAMA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLAMA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LAMA4
DgiDB (Drug Gene Interaction Database)LAMA4
DoCM (Curated mutations)LAMA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAMA4 (select a term)
intoGenLAMA4
Cancer3DLAMA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600133    615235   
Orphanet635   
DisGeNETLAMA4
MedgenLAMA4
Genetic Testing Registry LAMA4
NextProtQ16363 [Medical]
TSGene3910
GENETestsLAMA4
Target ValidationLAMA4
Huge Navigator LAMA4 [HugePedia]
snp3D : Map Gene to Disease3910
BioCentury BCIQLAMA4
ClinGenLAMA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3910
Chemical/Pharm GKB GenePA30273
Clinical trialLAMA4
Miscellaneous
canSAR (ICR)LAMA4 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAMA4
EVEXLAMA4
GoPubMedLAMA4
iHOPLAMA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:32:43 CEST 2018

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