LAMA4 (laminin subunit alpha 4)

2003-06-01  

Identity

HGNC
LOCATION
6q21
LOCUSID
ALIAS
CMD1JJ,LAMA3,LAMA4*-1
FUSION GENES

Other Information

Locus ID:

NCBI: 3910
MIM: 600133
HGNC: 6484
Ensembl: ENSG00000112769

Variants:

dbSNP: 3910
ClinVar: 3910
TCGA: ENSG00000112769
COSMIC: LAMA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112769ENST00000230538A0A0A0MQS9
ENSG00000112769ENST00000243219E5RFD7
ENSG00000112769ENST00000368638Q16363
ENSG00000112769ENST00000368640H0Y351
ENSG00000112769ENST00000389463A0A0A0MTC7
ENSG00000112769ENST00000424408A0A0A0MTC7
ENSG00000112769ENST00000431543Q6LET9
ENSG00000112769ENST00000453937Q16363
ENSG00000112769ENST00000455073Q16363
ENSG00000112769ENST00000519932E5RHF3
ENSG00000112769ENST00000521398E5RFQ2
ENSG00000112769ENST00000521690E5RK79
ENSG00000112769ENST00000521732H0YAQ5
ENSG00000112769ENST00000522006A0A0A0MTC7
ENSG00000112769ENST00000523765H0YAP9
ENSG00000112769ENST00000651529A0A494C1K8
ENSG00000112769ENST00000651860A0A494C139

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Small cell lung cancerKEGGko05222
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Signal TransductionREACTOMER-HSA-162582
Extracellular matrix organizationREACTOMER-HSA-1474244
Laminin interactionsREACTOMER-HSA-3000157
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
ECM proteoglycansREACTOMER-HSA-3000178
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET activates PTK2 signalingREACTOMER-HSA-8874081

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176465802007Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.74
124542882002Complex interactions between the laminin alpha 4 subunit and integrins regulate endothelial cell behavior in vitro and angiogenesis in vivo.44
123937392003Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.30
189786782008Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.21
276142942017The role of laminins in the organization and function of neuromuscular junctions.20
269213262016MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome.18
249519302014Laminins 411 and 421 differentially promote tumor cell migration via α6β1 integrin and MCAM (CD146).17
161467152006Changes in laminin isoforms associated with brain tumor invasion and angiogenesis.16
184967062008Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells.15
149805212004The alpha4 laminin subunit regulates endothelial cell survival.14

Citation

Dessen P

LAMA4 (laminin subunit alpha 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41114/lama4