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LAMA5 (laminin subunit alpha 5)

Identity

Alias_nameslaminin
Other alias-
HGNC (Hugo) LAMA5
LocusID (NCBI) 3911
Atlas_Id 46333
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 62309060 and ends at 62367312 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AATK (17q25.3) / LAMA5 (20q13.33)GSTP1 (11q13.2) / LAMA5 (20q13.33)H19 (11p15.5) / LAMA5 (20q13.33)
LAMA5 (20q13.33) / AATK (17q25.3)LAMA5 (20q13.33) / AGPAT3 (21q22.3)LAMA5 (20q13.33) / CABLES2 (20q13.33)
LAMA5 (20q13.33) / MYRFL (12q15)LAMA5 (20q13.33) / NCOR2 (12q24.31)LAMA5 (20q13.33) / UBN1 (16p13.3)
PTPRA (20p13) / LAMA5 (20q13.33)RPLP1 (15q23) / LAMA5 (20q13.33)TAF4 (20q13.33) / LAMA5 (20q13.33)
UBN1 (16p13.3) / LAMA5 (20q13.33)LAMA5 20q13.33 C12orf28LAMA5 20q13.33 / CABLES2 20q13.33
LAMA5 20q13.33 / NCOR2 12q24.31LAMA5 20q13.33 / UBN1 16p13.3TAF4 20q13.33 / LAMA5 20q13.33
UBN1 16p13.3 / LAMA5 20q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LAMA5   6485
Cards
Entrez_Gene (NCBI)LAMA5  3911  laminin subunit alpha 5
Aliases
GeneCards (Weizmann)LAMA5
Ensembl hg19 (Hinxton)ENSG00000130702 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130702 [Gene_View]  chr20:62309060-62367312 [Contig_View]  LAMA5 [Vega]
ICGC DataPortalENSG00000130702
TCGA cBioPortalLAMA5
AceView (NCBI)LAMA5
Genatlas (Paris)LAMA5
WikiGenes3911
SOURCE (Princeton)LAMA5
Genetics Home Reference (NIH)LAMA5
Genomic and cartography
GoldenPath hg38 (UCSC)LAMA5  -     chr20:62309060-62367312 -  20q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAMA5  -     20q13.33   [Description]    (hg19-Feb_2009)
EnsemblLAMA5 - 20q13.33 [CytoView hg19]  LAMA5 - 20q13.33 [CytoView hg38]
Mapping of homologs : NCBILAMA5 [Mapview hg19]  LAMA5 [Mapview hg38]
OMIM601033   
Gene and transcription
Genbank (Entrez)AB010099 AB011105 AB067494 AF443072 AK074307
RefSeq transcript (Entrez)NM_005560
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LAMA5
Cluster EST : UnigeneHs.473256 [ NCBI ]
CGAP (NCI)Hs.473256
Alternative Splicing GalleryENSG00000130702
Gene ExpressionLAMA5 [ NCBI-GEO ]   LAMA5 [ EBI - ARRAY_EXPRESS ]   LAMA5 [ SEEK ]   LAMA5 [ MEM ]
Gene Expression Viewer (FireBrowse)LAMA5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3911
GTEX Portal (Tissue expression)LAMA5
Human Protein AtlasENSG00000130702-LAMA5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15230   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15230  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15230
Splice isoforms : SwissVarO15230
PhosPhoSitePlusO15230
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    LAM_G_DOMAIN (PS50025)    LAMININ_IVA (PS51115)    LAMININ_NTER (PS51117)   
Domains : Interpro (EBI)ConA-like_dom    EGF-like_dom    Laminin_aI    Laminin_domII    Laminin_EGF    Laminin_G    Laminin_IV    Laminin_N    TNFR/NGFR_Cys_rich_reg   
Domain families : Pfam (Sanger)Laminin_B (PF00052)    Laminin_EGF (PF00053)    Laminin_G_2 (PF02210)    Laminin_I (PF06008)    Laminin_II (PF06009)    Laminin_N (PF00055)   
Domain families : Pfam (NCBI)pfam00052    pfam00053    pfam02210    pfam06008    pfam06009    pfam00055   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_Lam (SM00180)  LamB (SM00281)  LamG (SM00282)  LamNT (SM00136)  
Conserved Domain (NCBI)LAMA5
DMDM Disease mutations3911
Blocks (Seattle)LAMA5
SuperfamilyO15230
Human Protein Atlas [tissue]ENSG00000130702-LAMA5 [tissue]
Peptide AtlasO15230
HPRD03020
IPIIPI00783665   IPI00477868   IPI00977914   IPI00945870   
Protein Interaction databases
DIP (DOE-UCLA)O15230
IntAct (EBI)O15230
FunCoupENSG00000130702
BioGRIDLAMA5
STRING (EMBL)LAMA5
ZODIACLAMA5
Ontologies - Pathways
QuickGOO15230
Ontology : AmiGOangiogenesis  branching involved in ureteric bud morphogenesis  morphogenesis of a polarized epithelium  neural crest cell migration  hair follicle development  integrin binding  structural molecule activity  extracellular region  basement membrane  basal lamina  laminin-5 complex  extracellular space  nucleus  cytoskeleton organization  integrin-mediated signaling pathway  muscle organ development  cell recognition  cell proliferation  embryo development  morphogenesis of embryonic epithelium  cell migration  cell differentiation  regulation of cell adhesion  extracellular matrix organization  lung development  regulation of cell migration  extracellular matrix  extracellular matrix  substrate adhesion-dependent cell spreading  regulation of cell proliferation  odontogenesis of dentin-containing tooth  synaptic cleft  laminin-10 complex  laminin-10 complex  laminin-11 complex  endothelial cell differentiation  regulation of embryonic development  focal adhesion assembly  cilium assembly  branching involved in salivary gland morphogenesis  extracellular exosome  establishment of protein localization to plasma membrane  
Ontology : EGO-EBIangiogenesis  branching involved in ureteric bud morphogenesis  morphogenesis of a polarized epithelium  neural crest cell migration  hair follicle development  integrin binding  structural molecule activity  extracellular region  basement membrane  basal lamina  laminin-5 complex  extracellular space  nucleus  cytoskeleton organization  integrin-mediated signaling pathway  muscle organ development  cell recognition  cell proliferation  embryo development  morphogenesis of embryonic epithelium  cell migration  cell differentiation  regulation of cell adhesion  extracellular matrix organization  lung development  regulation of cell migration  extracellular matrix  extracellular matrix  substrate adhesion-dependent cell spreading  regulation of cell proliferation  odontogenesis of dentin-containing tooth  synaptic cleft  laminin-10 complex  laminin-10 complex  laminin-11 complex  endothelial cell differentiation  regulation of embryonic development  focal adhesion assembly  cilium assembly  branching involved in salivary gland morphogenesis  extracellular exosome  establishment of protein localization to plasma membrane  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Toxoplasmosis    Amoebiasis    Pathways in cancer    Small cell lung cancer   
NDEx NetworkLAMA5
Atlas of Cancer Signalling NetworkLAMA5
Wikipedia pathwaysLAMA5
Orthology - Evolution
OrthoDB3911
GeneTree (enSembl)ENSG00000130702
Phylogenetic Trees/Animal Genes : TreeFamLAMA5
HOVERGENO15230
HOGENOMO15230
Homologs : HomoloGeneLAMA5
Homology/Alignments : Family Browser (UCSC)LAMA5
Gene fusions - Rearrangements
Fusion : MitelmanAATK/LAMA5 [17q25.3/20q13.33]  [t(17;20)(q25;q13)]  
Fusion : MitelmanLAMA5/AATK [20q13.33/17q25.3]  [t(17;20)(q25;q13)]  
Fusion : MitelmanLAMA5/CABLES2 [20q13.33/20q13.33]  [t(20;20)(q13;q13)]  
Fusion : MitelmanLAMA5/MYRFL [20q13.33/12q15]  [t(12;20)(q15;q13)]  
Fusion : MitelmanLAMA5/NCOR2 [20q13.33/12q24.31]  [t(12;20)(q24;q13)]  
Fusion : MitelmanLAMA5/UBN1 [20q13.33/16p13.3]  [t(16;20)(p13;q13)]  
Fusion : MitelmanTAF4/LAMA5 [20q13.33/20q13.33]  [t(20;20)(q13;q13)]  
Fusion : MitelmanUBN1/LAMA5 [16p13.3/20q13.33]  [t(16;20)(p13;q13)]  
Fusion: TCGA_MDACCLAMA5 20q13.33 C12orf28 BRCA
Fusion: TCGA_MDACCLAMA5 20q13.33 CABLES2 20q13.33 LUAD
Fusion: TCGA_MDACCLAMA5 20q13.33 NCOR2 12q24.31 OV
Fusion: TCGA_MDACCLAMA5 20q13.33 UBN1 16p13.3 BRCA
Fusion: TCGA_MDACCTAF4 20q13.33 LAMA5 20q13.33 BLCA
Fusion: TCGA_MDACCUBN1 16p13.3 LAMA5 20q13.33 BRCA
Tumor Fusion PortalLAMA5
Fusion Cancer (Beijing)RPLP1 [15q23]  -  LAMA5 [20q13.33]  [FUSC004551]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAMA5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMA5
dbVarLAMA5
ClinVarLAMA5
1000_GenomesLAMA5 
Exome Variant ServerLAMA5
ExAC (Exome Aggregation Consortium)ENSG00000130702
GNOMAD BrowserENSG00000130702
Genetic variants : HAPMAP3911
Genomic Variants (DGV)LAMA5 [DGVbeta]
DECIPHERLAMA5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAMA5 
Mutations
ICGC Data PortalLAMA5 
TCGA Data PortalLAMA5 
Broad Tumor PortalLAMA5
OASIS PortalLAMA5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAMA5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLAMA5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAMA5
DgiDB (Drug Gene Interaction Database)LAMA5
DoCM (Curated mutations)LAMA5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAMA5 (select a term)
intoGenLAMA5
Cancer3DLAMA5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601033   
Orphanet
DisGeNETLAMA5
MedgenLAMA5
Genetic Testing Registry LAMA5
NextProtO15230 [Medical]
TSGene3911
GENETestsLAMA5
Target ValidationLAMA5
Huge Navigator LAMA5 [HugePedia]
snp3D : Map Gene to Disease3911
BioCentury BCIQLAMA5
ClinGenLAMA5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3911
Chemical/Pharm GKB GenePA30274
Clinical trialLAMA5
Miscellaneous
canSAR (ICR)LAMA5 (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAMA5
EVEXLAMA5
GoPubMedLAMA5
iHOPLAMA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:19:28 CET 2017

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