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LAMB2 (laminin subunit beta 2)

Identity

Other namesLAMS
NPHS5
HGNC (Hugo) LAMB2
LocusID (NCBI) 3913
Atlas_Id 41116
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49158547 and ends at 49170599 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LAMB2 (3p21.31) / ADGRG5 (16q21)LAMB2 (3p21.31) / HNRNPD (4q21.22)LAMB2 (3p21.31) / LAMB2 (3p21.31)
LAMB2 (3p21.31) / RAB1B (11q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LAMB2   6487
Cards
Entrez_Gene (NCBI)LAMB2  3913  laminin subunit beta 2
AliasesLAMS; NPHS5
GeneCards (Weizmann)LAMB2
Ensembl hg19 (Hinxton)ENSG00000172037 [Gene_View]  chr3:49158547-49170599 [Contig_View]  LAMB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000172037 [Gene_View]  chr3:49158547-49170599 [Contig_View]  LAMB2 [Vega]
ICGC DataPortalENSG00000172037
TCGA cBioPortalLAMB2
AceView (NCBI)LAMB2
Genatlas (Paris)LAMB2
WikiGenes3913
SOURCE (Princeton)LAMB2
Genomic and cartography
GoldenPath hg19 (UCSC)LAMB2  -     chr3:49158547-49170599 -  3p21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LAMB2  -     3p21.31   [Description]    (hg38-Dec_2013)
EnsemblLAMB2 - 3p21.31 [CytoView hg19]  LAMB2 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBILAMB2 [Mapview hg19]  LAMB2 [Mapview hg38]
OMIM150325   609049   614199   
Gene and transcription
Genbank (Entrez)AK094050 BC172384 BP354643 CN265778 CN265784
RefSeq transcript (Entrez)NM_002292
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_008094 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)LAMB2
Cluster EST : UnigeneHs.439726 [ NCBI ]
CGAP (NCI)Hs.439726
Alternative Splicing GalleryENSG00000172037
Gene ExpressionLAMB2 [ NCBI-GEO ]   LAMB2 [ EBI - ARRAY_EXPRESS ]   LAMB2 [ SEEK ]   LAMB2 [ MEM ]
Gene Expression Viewer (FireBrowse)LAMB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3913
GTEX Portal (Tissue expression)LAMB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55268 (Uniprot)
NextProtP55268  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55268
Splice isoforms : SwissVarP55268 (Swissvar)
PhosPhoSitePlusP55268
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    LAMININ_IVB (PS51116)    LAMININ_NTER (PS51117)   
Domains : Interpro (EBI)EGF-like_CS    Laminin_EGF    Laminin_IV_B    Laminin_N   
Domain families : Pfam (Sanger)Laminin_EGF (PF00053)    Laminin_N (PF00055)   
Domain families : Pfam (NCBI)pfam00053    pfam00055   
Domain families : Smart (EMBL)EGF_Lam (SM00180)  LamNT (SM00136)  
DMDM Disease mutations3913
Blocks (Seattle)LAMB2
SuperfamilyP55268
Human Protein AtlasENSG00000172037
Peptide AtlasP55268
HPRD01034
IPIIPI00296922   IPI00743203   
Protein Interaction databases
DIP (DOE-UCLA)P55268
IntAct (EBI)P55268
FunCoupENSG00000172037
BioGRIDLAMB2
STRING (EMBL)LAMB2
ZODIACLAMB2
Ontologies - Pathways
QuickGOP55268
Ontology : AmiGOintegrin binding  structural molecule activity  extracellular region  basement membrane  basal lamina  laminin-3 complex  cell adhesion  axon guidance  neuromuscular junction development  visual perception  astrocyte development  Schwann cell development  extracellular matrix organization  extracellular matrix  extracellular matrix  laminin-11 complex  synapse  axon extension involved in regeneration  retina development in camera-type eye  extracellular exosome  metanephric glomerular visceral epithelial cell development  metanephric glomerular basement membrane development  
Ontology : EGO-EBIintegrin binding  structural molecule activity  extracellular region  basement membrane  basal lamina  laminin-3 complex  cell adhesion  axon guidance  neuromuscular junction development  visual perception  astrocyte development  Schwann cell development  extracellular matrix organization  extracellular matrix  extracellular matrix  laminin-11 complex  synapse  axon extension involved in regeneration  retina development in camera-type eye  extracellular exosome  metanephric glomerular visceral epithelial cell development  metanephric glomerular basement membrane development  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Toxoplasmosis    Amoebiasis    Pathways in cancer    Small cell lung cancer   
NDEx Network
Atlas of Cancer Signalling NetworkLAMB2
Wikipedia pathwaysLAMB2
Orthology - Evolution
OrthoDB3913
GeneTree (enSembl)ENSG00000172037
Phylogenetic Trees/Animal Genes : TreeFamLAMB2
Homologs : HomoloGeneLAMB2
Homology/Alignments : Family Browser (UCSC)LAMB2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLAMB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMB2
dbVarLAMB2
ClinVarLAMB2
1000_GenomesLAMB2 
Exome Variant ServerLAMB2
ExAC (Exome Aggregation Consortium)LAMB2 (select the gene name)
Genetic variants : HAPMAP3913
Genomic Variants (DGV)LAMB2 [DGVbeta]
Mutations
ICGC Data PortalLAMB2 
TCGA Data PortalLAMB2 
Broad Tumor PortalLAMB2
OASIS PortalLAMB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAMB2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)Magdeburg Mutation Database
BioMutasearch LAMB2
DgiDB (Drug Gene Interaction Database)LAMB2
DoCM (Curated mutations)LAMB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAMB2 (select a term)
intoGenLAMB2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:49158547-49170599  ENSG00000172037
CONAN: Copy Number AnalysisLAMB2 
Mutations and Diseases : HGMDLAMB2
OMIM150325    609049    614199   
MedgenLAMB2
Genetic Testing Registry LAMB2
NextProtP55268 [Medical]
TSGene3913
GENETestsLAMB2
Huge Navigator LAMB2 [HugePedia]
snp3D : Map Gene to Disease3913
BioCentury BCIQLAMB2
ClinGenLAMB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3913
Chemical/Pharm GKB GenePA164741827
Clinical trialLAMB2
Miscellaneous
canSAR (ICR)LAMB2 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAMB2
EVEXLAMB2
GoPubMedLAMB2
iHOPLAMB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:05:03 CEST 2016

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