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LAMB3 (laminin subunit beta 3)

Identity

Other namesAI1A
BM600-125KDA
LAM5
LAMNB1
HGNC (Hugo) LAMB3
LocusID (NCBI) 3914
Atlas_Id 41117
Location 1q32.2  [Link to chromosome band 1q32]
Location_base_pair Starts at 209788218 and ends at 209825820 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADGRF4 (6p12.3) / LAMB3 (1q32.2)DGCR2 (22q11.21) / LAMB3 (1q32.2)ITGA3 (17q21.33) / LAMB3 (1q32.2)
LAMB3 (1q32.2) / KIFC3 (16q21)LAMB3 (1q32.2) / LAMB3 (1q32.2)LAMB3 (1q32.2) / NAB1 (2q32.2)
LAMB3 (1q32.2) / STOX2 (4q35.1)LAMB3 (1q32.2) / TBL1X (Xp22.31)RALGPS2 (1q25.2) / LAMB3 (1q32.2)
LAMB3 1q32.2 / NAB1 2q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LAMB3   6490
Cards
Entrez_Gene (NCBI)LAMB3  3914  laminin subunit beta 3
AliasesAI1A; BM600-125KDA; LAM5; LAMNB1
GeneCards (Weizmann)LAMB3
Ensembl hg19 (Hinxton)ENSG00000196878 [Gene_View]  chr1:209788218-209825820 [Contig_View]  LAMB3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196878 [Gene_View]  chr1:209788218-209825820 [Contig_View]  LAMB3 [Vega]
ICGC DataPortalENSG00000196878
TCGA cBioPortalLAMB3
AceView (NCBI)LAMB3
Genatlas (Paris)LAMB3
WikiGenes3914
SOURCE (Princeton)LAMB3
Genomic and cartography
GoldenPath hg19 (UCSC)LAMB3  -     chr1:209788218-209825820 -  1q32.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LAMB3  -     1q32.2   [Description]    (hg38-Dec_2013)
EnsemblLAMB3 - 1q32.2 [CytoView hg19]  LAMB3 - 1q32.2 [CytoView hg38]
Mapping of homologs : NCBILAMB3 [Mapview hg19]  LAMB3 [Mapview hg38]
OMIM104530   150310   226650   226700   
Gene and transcription
Genbank (Entrez)AK296851 AK309524 AL555685 AY035783 BC058922
RefSeq transcript (Entrez)NM_000228 NM_001017402 NM_001127641
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_007116 NT_004487 NW_004929294
Consensus coding sequences : CCDS (NCBI)LAMB3
Cluster EST : UnigeneHs.497636 [ NCBI ]
CGAP (NCI)Hs.497636
Alternative Splicing GalleryENSG00000196878
Gene ExpressionLAMB3 [ NCBI-GEO ]   LAMB3 [ EBI - ARRAY_EXPRESS ]   LAMB3 [ SEEK ]   LAMB3 [ MEM ]
Gene Expression Viewer (FireBrowse)LAMB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3914
GTEX Portal (Tissue expression)LAMB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13751 (Uniprot)
NextProtQ13751  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13751
Splice isoforms : SwissVarQ13751 (Swissvar)
PhosPhoSitePlusQ13751
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    LAMININ_NTER (PS51117)   
Domains : Interpro (EBI)EGF-like_CS    Laminin_EGF    Laminin_N   
Domain families : Pfam (Sanger)Laminin_EGF (PF00053)    Laminin_N (PF00055)   
Domain families : Pfam (NCBI)pfam00053    pfam00055   
Domain families : Smart (EMBL)EGF_Lam (SM00180)  LamNT (SM00136)  
DMDM Disease mutations3914
Blocks (Seattle)LAMB3
SuperfamilyQ13751
Human Protein AtlasENSG00000196878
Peptide AtlasQ13751
HPRD01032
IPIIPI00299404   IPI00478330   IPI00643244   
Protein Interaction databases
DIP (DOE-UCLA)Q13751
IntAct (EBI)Q13751
FunCoupENSG00000196878
BioGRIDLAMB3
STRING (EMBL)LAMB3
ZODIACLAMB3
Ontologies - Pathways
QuickGOQ13751
Ontology : AmiGOstructural molecule activity  protein binding  extracellular region  laminin-5 complex  cell adhesion  epidermis development  extracellular matrix disassembly  extracellular matrix organization  hemidesmosome assembly  protein complex binding  endodermal cell differentiation  brown fat cell differentiation  
Ontology : EGO-EBIstructural molecule activity  protein binding  extracellular region  laminin-5 complex  cell adhesion  epidermis development  extracellular matrix disassembly  extracellular matrix organization  hemidesmosome assembly  protein complex binding  endodermal cell differentiation  brown fat cell differentiation  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Toxoplasmosis    Amoebiasis    Pathways in cancer    Small cell lung cancer   
NDEx Network
Atlas of Cancer Signalling NetworkLAMB3
Wikipedia pathwaysLAMB3
Orthology - Evolution
OrthoDB3914
GeneTree (enSembl)ENSG00000196878
Phylogenetic Trees/Animal Genes : TreeFamLAMB3
Homologs : HomoloGeneLAMB3
Homology/Alignments : Family Browser (UCSC)LAMB3
Gene fusions - Rearrangements
Fusion: TCGALAMB3 1q32.2 NAB1 2q32.2 HNSC
Polymorphisms : SNP, variants
NCBI Variation ViewerLAMB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMB3
dbVarLAMB3
ClinVarLAMB3
1000_GenomesLAMB3 
Exome Variant ServerLAMB3
ExAC (Exome Aggregation Consortium)LAMB3 (select the gene name)
Genetic variants : HAPMAP3914
Genomic Variants (DGV)LAMB3 [DGVbeta]
Mutations
ICGC Data PortalLAMB3 
TCGA Data PortalLAMB3 
Broad Tumor PortalLAMB3
OASIS PortalLAMB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAMB3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAMB3
DgiDB (Drug Gene Interaction Database)LAMB3
DoCM (Curated mutations)LAMB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAMB3 (select a term)
intoGenLAMB3
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:209788218-209825820  ENSG00000196878
CONAN: Copy Number AnalysisLAMB3 
Mutations and Diseases : HGMDLAMB3
OMIM104530    150310    226650    226700   
MedgenLAMB3
Genetic Testing Registry LAMB3
NextProtQ13751 [Medical]
TSGene3914
GENETestsLAMB3
Huge Navigator LAMB3 [HugePedia]
snp3D : Map Gene to Disease3914
BioCentury BCIQLAMB3
ClinGenLAMB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3914
Chemical/Pharm GKB GenePA30278
Clinical trialLAMB3
Miscellaneous
canSAR (ICR)LAMB3 (select the gene name)
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAMB3
EVEXLAMB3
GoPubMedLAMB3
iHOPLAMB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:05:04 CEST 2016

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