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LAMC1 (laminin, gamma 1 (formerly LAMB2))

Identity

Other namesLAMB2
HGNC (Hugo) LAMC1
LocusID (NCBI) 3915
Location 1q25.3
Location_base_pair Starts at 182992595 and ends at 183114727 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LAMC1   6492
Cards
Entrez_Gene (NCBI)LAMC1  3915  laminin, gamma 1 (formerly LAMB2)
GeneCards (Weizmann)LAMC1
Ensembl hg19 (Hinxton)ENSG00000135862 [Gene_View]  chr1:182992595-183114727 [Contig_View]  LAMC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000135862 [Gene_View]  chr1:182992595-183114727 [Contig_View]  LAMC1 [Vega]
ICGC DataPortalENSG00000135862
cBioPortalLAMC1
AceView (NCBI)LAMC1
Genatlas (Paris)LAMC1
WikiGenes3915
SOURCE (Princeton)LAMC1
Genomic and cartography
GoldenPath hg19 (UCSC)LAMC1  -     chr1:182992595-183114727 +  1q25.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LAMC1  -     1q25.3   [Description]    (hg38-Dec_2013)
EnsemblLAMC1 - 1q25.3 [CytoView hg19]  LAMC1 - 1q25.3 [CytoView hg38]
Mapping of homologs : NCBILAMC1 [Mapview hg19]  LAMC1 [Mapview hg38]
OMIM150290   
Gene and transcription
Genbank (Entrez)BC015586 BC035429 BC067813 BF507385 BI768612
RefSeq transcript (Entrez)NM_002293
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_011463 NT_004487 NW_001838533 NW_004929293
Consensus coding sequences : CCDS (NCBI)LAMC1
Cluster EST : UnigeneHs.609663 [ NCBI ]
CGAP (NCI)Hs.609663
Alternative Splicing : Fast-db (Paris)GSHG0001257
Alternative Splicing GalleryENSG00000135862
Gene ExpressionLAMC1 [ NCBI-GEO ]     LAMC1 [ SEEK ]   LAMC1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11047 (Uniprot)
NextProtP11047  [Medical]
With graphics : InterProP11047
Splice isoforms : SwissVarP11047 (Swissvar)
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    LAMININ_IVA (PS51115)    LAMININ_NTER (PS51117)   
Domains : Interpro (EBI)EGF-like_CS    EGF_laminin    Galactose-bd-like    Laminin_B_subgr    Laminin_B_type_IV    Laminin_N   
Related proteins : CluSTrP11047
Domain families : Pfam (Sanger)Laminin_B (PF00052)    Laminin_EGF (PF00053)    Laminin_N (PF00055)   
Domain families : Pfam (NCBI)pfam00052    pfam00053    pfam00055   
Domain families : Smart (EMBL)EGF_Lam (SM00180)  LamB (SM00281)  LamNT (SM00136)  
DMDM Disease mutations3915
Blocks (Seattle)P11047
Human Protein AtlasENSG00000135862
Peptide AtlasP11047
HPRD01030
IPIIPI00298281   IPI00409735   
Protein Interaction databases
DIP (DOE-UCLA)P11047
IntAct (EBI)P11047
FunCoupENSG00000135862
BioGRIDLAMC1
IntegromeDBLAMC1
STRING (EMBL)LAMC1
Ontologies - Pathways
QuickGOP11047
Ontology : AmiGOextracellular matrix structural constituent  extracellular region  basement membrane  laminin-1 complex  laminin-1 complex  extracellular space  protein complex assembly  cell adhesion  axon guidance  endoderm development  cell migration  extracellular matrix disassembly  extracellular matrix disassembly  extracellular matrix organization  extracellular matrix  extracellular matrix  hemidesmosome assembly  substrate adhesion-dependent cell spreading  glycosphingolipid binding  laminin-10 complex  laminin-11 complex  positive regulation of epithelial cell proliferation  extracellular vesicular exosome  
Ontology : EGO-EBIextracellular matrix structural constituent  extracellular region  basement membrane  laminin-1 complex  laminin-1 complex  extracellular space  protein complex assembly  cell adhesion  axon guidance  endoderm development  cell migration  extracellular matrix disassembly  extracellular matrix disassembly  extracellular matrix organization  extracellular matrix  extracellular matrix  hemidesmosome assembly  substrate adhesion-dependent cell spreading  glycosphingolipid binding  laminin-10 complex  laminin-11 complex  positive regulation of epithelial cell proliferation  extracellular vesicular exosome  
Pathways : BIOCARTAPrion Pathway [Genes]   
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Prion diseases    Toxoplasmosis    Amoebiasis    Pathways in cancer    Small cell lung cancer   
Protein Interaction DatabaseLAMC1
DoCM (Curated mutations)LAMC1
Wikipedia pathwaysLAMC1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLAMC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMC1
dbVarLAMC1
ClinVarLAMC1
1000_GenomesLAMC1 
Exome Variant ServerLAMC1
SNP (GeneSNP Utah)LAMC1
SNP : HGBaseLAMC1
Genetic variants : HAPMAPLAMC1
Genomic VariantsLAMC1  LAMC1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000135862 
Somatic Mutations in Cancer : COSMICLAMC1 
CONAN: Copy Number AnalysisLAMC1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:182992595-183114727
Mutations and Diseases : HGMDLAMC1
OMIM150290   
MedgenLAMC1
NextProtP11047 [Medical]
GENETestsLAMC1
Disease Genetic AssociationLAMC1
Huge Navigator LAMC1 [HugePedia]  LAMC1 [HugeCancerGEM]
snp3D : Map Gene to Disease3915
DGIdb (Drug Gene Interaction db)LAMC1
General knowledge
Homologs : HomoloGeneLAMC1
Homology/Alignments : Family Browser (UCSC)LAMC1
Phylogenetic Trees/Animal Genes : TreeFamLAMC1
Chemical/Protein Interactions : CTD3915
Chemical/Pharm GKB GenePA30280
Clinical trialLAMC1
Cancer Resource (Charite)ENSG00000135862
Other databases
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
CoreMineLAMC1
GoPubMedLAMC1
iHOPLAMC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:24:53 CET 2014

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