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LAMC3 (laminin subunit gamma 3)

Identity

Alias_nameslaminin
Alias_symbol (synonym)DKFZp434E202
Other aliasOCCM
HGNC (Hugo) LAMC3
LocusID (NCBI) 10319
Atlas_Id 41120
Location 9q34.12  [Link to chromosome band 9q34]
Location_base_pair Starts at 133884504 and ends at 133968446 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AFF4 (5q31.1) / LAMC3 (9q34.12)KMT2A (11q23.3) / LAMC3 (9q34.12)LAMC3 (9q34.12) / LAMC3 (9q34.12)
LAMC3 (9q34.12) / NPHP3 (3q22.1)LOC100507412 (-) / LAMC3 (9q34.12)NAA35 (9q21.33) / LAMC3 (9q34.12)
LAMC3 9q34.12 / NPHP3 3q22.1NAA35 9q21.33 / LAMC3 9q34.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  NUP214/ABL1 fusion gene on amplified episomes


External links

Nomenclature
HGNC (Hugo)LAMC3   6494
Cards
Entrez_Gene (NCBI)LAMC3  10319  laminin subunit gamma 3
AliasesOCCM
GeneCards (Weizmann)LAMC3
Ensembl hg19 (Hinxton)ENSG00000050555 [Gene_View]  chr9:133884504-133968446 [Contig_View]  LAMC3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000050555 [Gene_View]  chr9:133884504-133968446 [Contig_View]  LAMC3 [Vega]
ICGC DataPortalENSG00000050555
TCGA cBioPortalLAMC3
AceView (NCBI)LAMC3
Genatlas (Paris)LAMC3
WikiGenes10319
SOURCE (Princeton)LAMC3
Genetics Home Reference (NIH)LAMC3
Genomic and cartography
GoldenPath hg19 (UCSC)LAMC3  -     chr9:133884504-133968446 +  9q34.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LAMC3  -     9q34.12   [Description]    (hg38-Dec_2013)
EnsemblLAMC3 - 9q34.12 [CytoView hg19]  LAMC3 - 9q34.12 [CytoView hg38]
Mapping of homologs : NCBILAMC3 [Mapview hg19]  LAMC3 [Mapview hg38]
OMIM604349   614115   
Gene and transcription
Genbank (Entrez)AB208887 AF041835 AK075536 AL133595 AL551493
RefSeq transcript (Entrez)NM_006059
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_029800 NT_008470 NW_004929367
Consensus coding sequences : CCDS (NCBI)LAMC3
Cluster EST : UnigeneHs.201805 [ NCBI ]
CGAP (NCI)Hs.201805
Alternative Splicing GalleryENSG00000050555
Gene ExpressionLAMC3 [ NCBI-GEO ]   LAMC3 [ EBI - ARRAY_EXPRESS ]   LAMC3 [ SEEK ]   LAMC3 [ MEM ]
Gene Expression Viewer (FireBrowse)LAMC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10319
GTEX Portal (Tissue expression)LAMC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6N6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6N6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6N6
Splice isoforms : SwissVarQ9Y6N6
PhosPhoSitePlusQ9Y6N6
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    LAMININ_IVA (PS51115)    LAMININ_NTER (PS51117)   
Domains : Interpro (EBI)Galactose-bd-like    Laminin_EGF    Laminin_IV    Laminin_N   
Domain families : Pfam (Sanger)Laminin_B (PF00052)    Laminin_EGF (PF00053)    Laminin_N (PF00055)   
Domain families : Pfam (NCBI)pfam00052    pfam00053    pfam00055   
Domain families : Smart (EMBL)EGF_Lam (SM00180)  LamNT (SM00136)  
Conserved Domain (NCBI)LAMC3
DMDM Disease mutations10319
Blocks (Seattle)LAMC3
SuperfamilyQ9Y6N6
Human Protein AtlasENSG00000050555
Peptide AtlasQ9Y6N6
HPRD05069
IPIIPI00178273   IPI00914899   IPI00641172   IPI00383802   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6N6
IntAct (EBI)Q9Y6N6
FunCoupENSG00000050555
BioGRIDLAMC3
STRING (EMBL)LAMC3
ZODIACLAMC3
Ontologies - Pathways
QuickGOQ9Y6N6
Ontology : AmiGOcell morphogenesis involved in differentiation  structural molecule activity  extracellular region  proteinaceous extracellular matrix  basement membrane  cell adhesion  visual perception  astrocyte development  membrane  extracellular matrix organization  retina development in camera-type eye  
Ontology : EGO-EBIcell morphogenesis involved in differentiation  structural molecule activity  extracellular region  proteinaceous extracellular matrix  basement membrane  cell adhesion  visual perception  astrocyte development  membrane  extracellular matrix organization  retina development in camera-type eye  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Toxoplasmosis    Amoebiasis    Pathways in cancer    Small cell lung cancer   
NDEx NetworkLAMC3
Atlas of Cancer Signalling NetworkLAMC3
Wikipedia pathwaysLAMC3
Orthology - Evolution
OrthoDB10319
GeneTree (enSembl)ENSG00000050555
Phylogenetic Trees/Animal Genes : TreeFamLAMC3
HOVERGENQ9Y6N6
HOGENOMQ9Y6N6
Homologs : HomoloGeneLAMC3
Homology/Alignments : Family Browser (UCSC)LAMC3
Gene fusions - Rearrangements
Fusion : MitelmanAFF4/LAMC3 [5q31.1/9q34.12]  [t(5;9)(q31;q34)]  
Fusion : MitelmanLAMC3/NPHP3 [9q34.12/3q22.1]  [t(3;9)(q22;q34)]  
Fusion : MitelmanNAA35/LAMC3 [9q21.33/9q34.12]  [t(9;9)(q21;q34)]  
Fusion: TCGALAMC3 9q34.12 NPHP3 3q22.1 PRAD
Fusion: TCGANAA35 9q21.33 LAMC3 9q34.12 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAMC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMC3
dbVarLAMC3
ClinVarLAMC3
1000_GenomesLAMC3 
Exome Variant ServerLAMC3
ExAC (Exome Aggregation Consortium)LAMC3 (select the gene name)
Genetic variants : HAPMAP10319
Genomic Variants (DGV)LAMC3 [DGVbeta]
DECIPHER (Syndromes)9:133884504-133968446  ENSG00000050555
CONAN: Copy Number AnalysisLAMC3 
Mutations
ICGC Data PortalLAMC3 
TCGA Data PortalLAMC3 
Broad Tumor PortalLAMC3
OASIS PortalLAMC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAMC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLAMC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch LAMC3
DgiDB (Drug Gene Interaction Database)LAMC3
DoCM (Curated mutations)LAMC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAMC3 (select a term)
intoGenLAMC3
Cancer3DLAMC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604349    614115   
Orphanet20488   
MedgenLAMC3
Genetic Testing Registry LAMC3
NextProtQ9Y6N6 [Medical]
TSGene10319
GENETestsLAMC3
Huge Navigator LAMC3 [HugePedia]
snp3D : Map Gene to Disease10319
BioCentury BCIQLAMC3
ClinGenLAMC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10319
Chemical/Pharm GKB GenePA30282
Clinical trialLAMC3
Miscellaneous
canSAR (ICR)LAMC3 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAMC3
EVEXLAMC3
GoPubMedLAMC3
iHOPLAMC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:06:42 CEST 2017

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