Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)

Identity

Alias_namesC11orf59
chromosome 11 open reading frame 59
Alias_symbol (synonym)FLJ20625
p18
p27RF-Rho
Pdro
Ragulator1
Other aliasPDRO
HGNC (Hugo) LAMTOR1
LocusID (NCBI) 55004
Atlas_Id 52126
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 72097292 and ends at 72103387 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FZD4 (11q14.2) / LAMTOR1 (11q13.4)LAMTOR1 (11q13.4) / PRKCD (3p21.1)FZD4 11q14.2 / LAMTOR1 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(3;11)(p21;q13) LAMTOR1/PRKCD
t(11;11)(q13;q14) FZD4/LAMTOR1


External links

Nomenclature
HGNC (Hugo)LAMTOR1   26068
Cards
Entrez_Gene (NCBI)LAMTOR1  55004  late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
AliasesC11orf59; PDRO; Ragulator1; p18; 
p27RF-Rho
GeneCards (Weizmann)LAMTOR1
Ensembl hg19 (Hinxton)ENSG00000149357 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149357 [Gene_View]  ENSG00000149357 [Sequence]  chr11:72097292-72103387 [Contig_View]  LAMTOR1 [Vega]
ICGC DataPortalENSG00000149357
TCGA cBioPortalLAMTOR1
AceView (NCBI)LAMTOR1
Genatlas (Paris)LAMTOR1
WikiGenes55004
SOURCE (Princeton)LAMTOR1
Genetics Home Reference (NIH)LAMTOR1
Genomic and cartography
GoldenPath hg38 (UCSC)LAMTOR1  -     chr11:72097292-72103387 -  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAMTOR1  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblLAMTOR1 - 11q13.4 [CytoView hg19]  LAMTOR1 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBILAMTOR1 [Mapview hg19]  LAMTOR1 [Mapview hg38]
OMIM613510   
Gene and transcription
Genbank (Entrez)AF289583 AK000632 AK300681 BC001706 BX381569
RefSeq transcript (Entrez)NM_017907
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LAMTOR1
Cluster EST : UnigeneHs.731528 [ NCBI ]
CGAP (NCI)Hs.731528
Alternative Splicing GalleryENSG00000149357
Gene ExpressionLAMTOR1 [ NCBI-GEO ]   LAMTOR1 [ EBI - ARRAY_EXPRESS ]   LAMTOR1 [ SEEK ]   LAMTOR1 [ MEM ]
Gene Expression Viewer (FireBrowse)LAMTOR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55004
GTEX Portal (Tissue expression)LAMTOR1
Human Protein AtlasENSG00000149357-LAMTOR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6IAA8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6IAA8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6IAA8
Splice isoforms : SwissVarQ6IAA8
PhosPhoSitePlusQ6IAA8
Domains : Interpro (EBI)LAMTOR1-like    LAMTOR1/MEH1   
Domain families : Pfam (Sanger)LAMTOR (PF15454)   
Domain families : Pfam (NCBI)pfam15454   
Domain families : Smart (EMBL)LAMTOR (SM01262)  
Conserved Domain (NCBI)LAMTOR1
DMDM Disease mutations55004
Blocks (Seattle)LAMTOR1
SuperfamilyQ6IAA8
Human Protein Atlas [tissue]ENSG00000149357-LAMTOR1 [tissue]
Peptide AtlasQ6IAA8
HPRD07933
IPIIPI00016670   IPI01014026   IPI01013627   IPI01010893   IPI00980723   IPI01012200   
Protein Interaction databases
DIP (DOE-UCLA)Q6IAA8
IntAct (EBI)Q6IAA8
FunCoupENSG00000149357
BioGRIDLAMTOR1
STRING (EMBL)LAMTOR1
ZODIACLAMTOR1
Ontologies - Pathways
QuickGOQ6IAA8
Ontology : AmiGOregulation of cell growth  regulation of receptor recycling  guanyl-nucleotide exchange factor activity  protein binding  lysosome  lysosomal membrane  plasma membrane  endosome organization  lysosome organization  cell cycle arrest  regulation of cholesterol esterification  regulation of cholesterol efflux  regulation of macroautophagy  late endosome membrane  positive regulation of TOR signaling  lysosome localization  endosome localization  protein complex scaffold activity  cellular protein localization  azurophil granule membrane  specific granule membrane  cholesterol homeostasis  neutrophil degranulation  positive regulation of MAPK cascade  membrane raft  GTPase binding  regulation of cholesterol import  regulation of molecular function  extracellular exosome  cellular response to amino acid stimulus  Ragulator complex  ficolin-1-rich granule membrane  
Ontology : EGO-EBIregulation of cell growth  regulation of receptor recycling  guanyl-nucleotide exchange factor activity  protein binding  lysosome  lysosomal membrane  plasma membrane  endosome organization  lysosome organization  cell cycle arrest  regulation of cholesterol esterification  regulation of cholesterol efflux  regulation of macroautophagy  late endosome membrane  positive regulation of TOR signaling  lysosome localization  endosome localization  protein complex scaffold activity  cellular protein localization  azurophil granule membrane  specific granule membrane  cholesterol homeostasis  neutrophil degranulation  positive regulation of MAPK cascade  membrane raft  GTPase binding  regulation of cholesterol import  regulation of molecular function  extracellular exosome  cellular response to amino acid stimulus  Ragulator complex  ficolin-1-rich granule membrane  
NDEx NetworkLAMTOR1
Atlas of Cancer Signalling NetworkLAMTOR1
Wikipedia pathwaysLAMTOR1
Orthology - Evolution
OrthoDB55004
GeneTree (enSembl)ENSG00000149357
Phylogenetic Trees/Animal Genes : TreeFamLAMTOR1
HOVERGENQ6IAA8
HOGENOMQ6IAA8
Homologs : HomoloGeneLAMTOR1
Homology/Alignments : Family Browser (UCSC)LAMTOR1
Gene fusions - Rearrangements
Fusion : MitelmanFZD4/LAMTOR1 [11q14.2/11q13.4]  [t(11;11)(q13;q14)]  
Fusion : MitelmanLAMTOR1/PRKCD [11q13.4/3p21.1]  [ins(11;3)(q13;p13p21)]  
Fusion PortalFZD4 11q14.2 LAMTOR1 11q13.4 BRCA
Fusion : QuiverLAMTOR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAMTOR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMTOR1
dbVarLAMTOR1
ClinVarLAMTOR1
1000_GenomesLAMTOR1 
Exome Variant ServerLAMTOR1
ExAC (Exome Aggregation Consortium)ENSG00000149357
GNOMAD BrowserENSG00000149357
Genetic variants : HAPMAP55004
Genomic Variants (DGV)LAMTOR1 [DGVbeta]
DECIPHERLAMTOR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAMTOR1 
Mutations
ICGC Data PortalLAMTOR1 
TCGA Data PortalLAMTOR1 
Broad Tumor PortalLAMTOR1
OASIS PortalLAMTOR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAMTOR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLAMTOR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAMTOR1
DgiDB (Drug Gene Interaction Database)LAMTOR1
DoCM (Curated mutations)LAMTOR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAMTOR1 (select a term)
intoGenLAMTOR1
Cancer3DLAMTOR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613510   
Orphanet
DisGeNETLAMTOR1
MedgenLAMTOR1
Genetic Testing Registry LAMTOR1
NextProtQ6IAA8 [Medical]
TSGene55004
GENETestsLAMTOR1
Target ValidationLAMTOR1
Huge Navigator LAMTOR1 [HugePedia]
snp3D : Map Gene to Disease55004
BioCentury BCIQLAMTOR1
ClinGenLAMTOR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55004
Chemical/Pharm GKB GenePA143485354
Clinical trialLAMTOR1
Miscellaneous
canSAR (ICR)LAMTOR1 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAMTOR1
EVEXLAMTOR1
GoPubMedLAMTOR1
iHOPLAMTOR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:32:46 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.