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LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2)

Identity

Alias (NCBI)ENDAP
HSPC003
MAPBPIP
MAPKSP1AP
ROBLD3
Ragulator2
p14
HGNC (Hugo) LAMTOR2
HGNC Alias symbMAPBPIP
MAPKSP1AP
p14
ENDAP
Ragulator2
HGNC Alias namemitogen activated protein binding protein interacting protein
 MAPKSP1 adaptor protein
 endosomal adaptor protein
HGNC Previous nameROBLD3
HGNC Previous nameroadblock domain containing 3
LocusID (NCBI) 28956
Atlas_Id 49903
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 156054782 and ends at 156058506 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSNK1A1 (5q32) / LAMTOR2 (1q22)GALNT14 (2p23.1) / LAMTOR2 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LAMTOR2   29796
LRG (Locus Reference Genomic)LRG_81
Cards
Entrez_Gene (NCBI)LAMTOR2    late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
AliasesENDAP; HSPC003; MAPBPIP; MAPKSP1AP; 
ROBLD3; Ragulator2; p14
GeneCards (Weizmann)LAMTOR2
Ensembl hg19 (Hinxton)ENSG00000116586 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116586 [Gene_View]  ENSG00000116586 [Sequence]  chr1:156054782-156058506 [Contig_View]  LAMTOR2 [Vega]
ICGC DataPortalENSG00000116586
TCGA cBioPortalLAMTOR2
AceView (NCBI)LAMTOR2
Genatlas (Paris)LAMTOR2
SOURCE (Princeton)LAMTOR2
Genetics Home Reference (NIH)LAMTOR2
Genomic and cartography
GoldenPath hg38 (UCSC)LAMTOR2  -     chr1:156054782-156058506 +  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAMTOR2  -     1q22   [Description]    (hg19-Feb_2009)
GoldenPathLAMTOR2 - 1q22 [CytoView hg19]  LAMTOR2 - 1q22 [CytoView hg38]
ImmunoBaseENSG00000116586
Genome Data Viewer NCBILAMTOR2 [Mapview hg19]  
OMIM610389   610798   
Gene and transcription
Genbank (Entrez)AF070659 AK307086 BC024190 BM353842 BU184679
RefSeq transcript (Entrez)NM_001145264 NM_014017
Consensus coding sequences : CCDS (NCBI)LAMTOR2
Gene ExpressionLAMTOR2 [ NCBI-GEO ]   LAMTOR2 [ EBI - ARRAY_EXPRESS ]   LAMTOR2 [ SEEK ]   LAMTOR2 [ MEM ]
Gene Expression Viewer (FireBrowse)LAMTOR2 [ Firebrowse - Broad ]
GenevisibleExpression of LAMTOR2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28956
GTEX Portal (Tissue expression)LAMTOR2
Human Protein AtlasENSG00000116586-LAMTOR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2Q5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2Q5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2Q5
PhosPhoSitePlusQ9Y2Q5
Domains : Interpro (EBI)LAMTOR2-like    Roadblock/LAMTOR2_dom   
Domain families : Pfam (Sanger)Robl_LC7 (PF03259)   
Domain families : Pfam (NCBI)pfam03259   
Domain families : Smart (EMBL)Robl_LC7 (SM00960)  
Conserved Domain (NCBI)LAMTOR2
PDB (RSDB)5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
PDB Europe5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
PDB (PDBSum)5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
PDB (IMB)5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
Structural Biology KnowledgeBase5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
SCOP (Structural Classification of Proteins)5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
CATH (Classification of proteins structures)5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
SuperfamilyQ9Y2Q5
AlphaFold pdb e-kbQ9Y2Q5   
Human Protein Atlas [tissue]ENSG00000116586-LAMTOR2 [tissue]
HPRD17463
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2Q5
IntAct (EBI)Q9Y2Q5
BioGRIDLAMTOR2
STRING (EMBL)LAMTOR2
ZODIACLAMTOR2
Ontologies - Pathways
QuickGOQ9Y2Q5
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  regulation of cell growth  guanyl-nucleotide exchange factor activity  protein binding  lysosomal membrane  lysosomal membrane  late endosome  plasma membrane  endosome membrane  fibroblast migration  regulation of macroautophagy  positive regulation of TOR signaling  positive regulation of TOR signaling  cellular response to amino acid starvation  cellular protein localization  specific granule membrane  neutrophil degranulation  molecular adaptor activity  tertiary granule membrane  cellular response to amino acid stimulus  cellular response to amino acid stimulus  Ragulator complex  Ragulator complex  regulation of cell-substrate junction organization  protein localization to cell junction  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  regulation of cell growth  guanyl-nucleotide exchange factor activity  protein binding  lysosomal membrane  lysosomal membrane  late endosome  plasma membrane  endosome membrane  fibroblast migration  regulation of macroautophagy  positive regulation of TOR signaling  positive regulation of TOR signaling  cellular response to amino acid starvation  cellular protein localization  specific granule membrane  neutrophil degranulation  molecular adaptor activity  tertiary granule membrane  cellular response to amino acid stimulus  cellular response to amino acid stimulus  Ragulator complex  Ragulator complex  regulation of cell-substrate junction organization  protein localization to cell junction  
NDEx NetworkLAMTOR2
Atlas of Cancer Signalling NetworkLAMTOR2
Wikipedia pathwaysLAMTOR2
Orthology - Evolution
OrthoDB28956
GeneTree (enSembl)ENSG00000116586
Phylogenetic Trees/Animal Genes : TreeFamLAMTOR2
Homologs : HomoloGeneLAMTOR2
Homology/Alignments : Family Browser (UCSC)LAMTOR2
Gene fusions - Rearrangements
Fusion : QuiverLAMTOR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAMTOR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMTOR2
dbVarLAMTOR2
ClinVarLAMTOR2
MonarchLAMTOR2
1000_GenomesLAMTOR2 
Exome Variant ServerLAMTOR2
GNOMAD BrowserENSG00000116586
Varsome BrowserLAMTOR2
ACMGLAMTOR2 variants
VarityQ9Y2Q5
Genomic Variants (DGV)LAMTOR2 [DGVbeta]
DECIPHERLAMTOR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAMTOR2 
Mutations
ICGC Data PortalLAMTOR2 
TCGA Data PortalLAMTOR2 
Broad Tumor PortalLAMTOR2
OASIS PortalLAMTOR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAMTOR2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLAMTOR2
Mutations and Diseases : HGMDLAMTOR2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLAMTOR2
DgiDB (Drug Gene Interaction Database)LAMTOR2
DoCM (Curated mutations)LAMTOR2
CIViC (Clinical Interpretations of Variants in Cancer)LAMTOR2
Cancer3DLAMTOR2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610389    610798   
Orphanet11925   
DisGeNETLAMTOR2
MedgenLAMTOR2
Genetic Testing Registry LAMTOR2
NextProtQ9Y2Q5 [Medical]
GENETestsLAMTOR2
Target ValidationLAMTOR2
Huge Navigator LAMTOR2 [HugePedia]
ClinGenLAMTOR2
Clinical trials, drugs, therapy
MyCancerGenomeLAMTOR2
Protein Interactions : CTDLAMTOR2
Pharm GKB GenePA164725527
PharosQ9Y2Q5
Clinical trialLAMTOR2
Miscellaneous
canSAR (ICR)LAMTOR2
HarmonizomeLAMTOR2
DataMed IndexLAMTOR2
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLAMTOR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:15:34 CEST 2021

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