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LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3)

Identity

Alias_namesMAP2K1IP1
MAPKSP1
mitogen-activated protein kinase kinase 1 interacting protein 1
MAPK scaffold protein 1
Alias_symbol (synonym)MP1
MAPBP
Ragulator3
Other aliasPRO0633
HGNC (Hugo) LAMTOR3
LocusID (NCBI) 8649
Atlas_Id 52098
Location 4q23  [Link to chromosome band 4q23]
Location_base_pair Starts at 99878338 and ends at 99894546 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ASCC2 (22q12.2) / LAMTOR3 (4q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LAMTOR3   15606
Cards
Entrez_Gene (NCBI)LAMTOR3  8649  late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
AliasesMAP2K1IP1; MAPBP; MAPKSP1; MP1; 
PRO0633; Ragulator3
GeneCards (Weizmann)LAMTOR3
Ensembl hg19 (Hinxton)ENSG00000109270 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109270 [Gene_View]  chr4:99878338-99894546 [Contig_View]  LAMTOR3 [Vega]
ICGC DataPortalENSG00000109270
TCGA cBioPortalLAMTOR3
AceView (NCBI)LAMTOR3
Genatlas (Paris)LAMTOR3
WikiGenes8649
SOURCE (Princeton)LAMTOR3
Genetics Home Reference (NIH)LAMTOR3
Genomic and cartography
GoldenPath hg38 (UCSC)LAMTOR3  -     chr4:99878338-99894546 -  4q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAMTOR3  -     4q23   [Description]    (hg19-Feb_2009)
EnsemblLAMTOR3 - 4q23 [CytoView hg19]  LAMTOR3 - 4q23 [CytoView hg38]
Mapping of homologs : NCBILAMTOR3 [Mapview hg19]  LAMTOR3 [Mapview hg38]
OMIM603296   
Gene and transcription
Genbank (Entrez)AF130115 AF201947 AF305816 AK022313 AK223311
RefSeq transcript (Entrez)NM_001243736 NM_021970
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LAMTOR3
Cluster EST : UnigeneHs.433332 [ NCBI ]
CGAP (NCI)Hs.433332
Alternative Splicing GalleryENSG00000109270
Gene ExpressionLAMTOR3 [ NCBI-GEO ]   LAMTOR3 [ EBI - ARRAY_EXPRESS ]   LAMTOR3 [ SEEK ]   LAMTOR3 [ MEM ]
Gene Expression Viewer (FireBrowse)LAMTOR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8649
GTEX Portal (Tissue expression)LAMTOR3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHA4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHA4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHA4
Splice isoforms : SwissVarQ9UHA4
PhosPhoSitePlusQ9UHA4
Domains : Interpro (EBI)LAMTOR3   
Domain families : Pfam (Sanger)MAPKK1_Int (PF08923)   
Domain families : Pfam (NCBI)pfam08923   
Domain families : Smart (EMBL)MAPKK1_Int (SM01278)  
Conserved Domain (NCBI)LAMTOR3
DMDM Disease mutations8649
Blocks (Seattle)LAMTOR3
PDB (SRS)1SKO    2ZL1    3CPT   
PDB (PDBSum)1SKO    2ZL1    3CPT   
PDB (IMB)1SKO    2ZL1    3CPT   
PDB (RSDB)1SKO    2ZL1    3CPT   
Structural Biology KnowledgeBase1SKO    2ZL1    3CPT   
SCOP (Structural Classification of Proteins)1SKO    2ZL1    3CPT   
CATH (Classification of proteins structures)1SKO    2ZL1    3CPT   
SuperfamilyQ9UHA4
Human Protein AtlasENSG00000109270
Peptide AtlasQ9UHA4
HPRD04485
IPIIPI00030919   IPI00064296   IPI00967162   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHA4
IntAct (EBI)Q9UHA4
FunCoupENSG00000109270
BioGRIDLAMTOR3
STRING (EMBL)LAMTOR3
ZODIACLAMTOR3
Ontologies - Pathways
QuickGOQ9UHA4
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  guanyl-nucleotide exchange factor activity  protein binding  lysosomal membrane  late endosome  plasma membrane  focal adhesion  cell cycle arrest  endosome membrane  macroautophagy  kinase activator activity  positive regulation of TOR signaling  protein complex scaffold  cellular protein localization  specific granule membrane  neutrophil degranulation  positive regulation of GTPase activity  extracellular exosome  tertiary granule membrane  cellular response to amino acid stimulus  Ragulator complex  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  guanyl-nucleotide exchange factor activity  protein binding  lysosomal membrane  late endosome  plasma membrane  focal adhesion  cell cycle arrest  endosome membrane  macroautophagy  kinase activator activity  positive regulation of TOR signaling  protein complex scaffold  cellular protein localization  specific granule membrane  neutrophil degranulation  positive regulation of GTPase activity  extracellular exosome  tertiary granule membrane  cellular response to amino acid stimulus  Ragulator complex  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkLAMTOR3
Atlas of Cancer Signalling NetworkLAMTOR3
Wikipedia pathwaysLAMTOR3
Orthology - Evolution
OrthoDB8649
GeneTree (enSembl)ENSG00000109270
Phylogenetic Trees/Animal Genes : TreeFamLAMTOR3
HOVERGENQ9UHA4
HOGENOMQ9UHA4
Homologs : HomoloGeneLAMTOR3
Homology/Alignments : Family Browser (UCSC)LAMTOR3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAMTOR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMTOR3
dbVarLAMTOR3
ClinVarLAMTOR3
1000_GenomesLAMTOR3 
Exome Variant ServerLAMTOR3
ExAC (Exome Aggregation Consortium)LAMTOR3 (select the gene name)
Genetic variants : HAPMAP8649
Genomic Variants (DGV)LAMTOR3 [DGVbeta]
DECIPHERLAMTOR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAMTOR3 
Mutations
ICGC Data PortalLAMTOR3 
TCGA Data PortalLAMTOR3 
Broad Tumor PortalLAMTOR3
OASIS PortalLAMTOR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAMTOR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLAMTOR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAMTOR3
DgiDB (Drug Gene Interaction Database)LAMTOR3
DoCM (Curated mutations)LAMTOR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAMTOR3 (select a term)
intoGenLAMTOR3
Cancer3DLAMTOR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603296   
Orphanet
MedgenLAMTOR3
Genetic Testing Registry LAMTOR3
NextProtQ9UHA4 [Medical]
TSGene8649
GENETestsLAMTOR3
Target ValidationLAMTOR3
Huge Navigator LAMTOR3 [HugePedia]
snp3D : Map Gene to Disease8649
BioCentury BCIQLAMTOR3
ClinGenLAMTOR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8649
Chemical/Pharm GKB GenePA164722189
Clinical trialLAMTOR3
Miscellaneous
canSAR (ICR)LAMTOR3 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAMTOR3
EVEXLAMTOR3
GoPubMedLAMTOR3
iHOPLAMTOR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:40:12 CEST 2017

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