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LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3)

Identity

Alias (NCBI)MAP2K1IP1
MAPBP
MAPKSP1
MP1
PRO0633
Ragulator3
HGNC (Hugo) LAMTOR3
HGNC Alias symbMP1
MAPBP
Ragulator3
HGNC Alias nameMEK partner 1
HGNC Previous nameMAP2K1IP1
 MAPKSP1
HGNC Previous namemitogen-activated protein kinase kinase 1 interacting protein 1
 MAPK scaffold protein 1
LocusID (NCBI) 8649
Atlas_Id 52098
Location 4q23  [Link to chromosome band 4q23]
Location_base_pair Starts at 99878336 and ends at 99894427 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASCC2 (22q12.2) / LAMTOR3 (4q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LAMTOR3   15606
Cards
Entrez_Gene (NCBI)LAMTOR3    late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
AliasesMAP2K1IP1; MAPBP; MAPKSP1; MP1; 
PRO0633; Ragulator3
GeneCards (Weizmann)LAMTOR3
Ensembl hg19 (Hinxton)ENSG00000109270 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109270 [Gene_View]  ENSG00000109270 [Sequence]  chr4:99878336-99894427 [Contig_View]  LAMTOR3 [Vega]
ICGC DataPortalENSG00000109270
TCGA cBioPortalLAMTOR3
AceView (NCBI)LAMTOR3
Genatlas (Paris)LAMTOR3
SOURCE (Princeton)LAMTOR3
Genetics Home Reference (NIH)LAMTOR3
Genomic and cartography
GoldenPath hg38 (UCSC)LAMTOR3  -     chr4:99878336-99894427 -  4q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAMTOR3  -     4q23   [Description]    (hg19-Feb_2009)
GoldenPathLAMTOR3 - 4q23 [CytoView hg19]  LAMTOR3 - 4q23 [CytoView hg38]
ImmunoBaseENSG00000109270
Genome Data Viewer NCBILAMTOR3 [Mapview hg19]  
OMIM603296   
Gene and transcription
Genbank (Entrez)AF130115 AF201947 AF305816 AK022313 AK223311
RefSeq transcript (Entrez)NM_001243736 NM_021970
Consensus coding sequences : CCDS (NCBI)LAMTOR3
Gene ExpressionLAMTOR3 [ NCBI-GEO ]   LAMTOR3 [ EBI - ARRAY_EXPRESS ]   LAMTOR3 [ SEEK ]   LAMTOR3 [ MEM ]
Gene Expression Viewer (FireBrowse)LAMTOR3 [ Firebrowse - Broad ]
GenevisibleExpression of LAMTOR3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8649
GTEX Portal (Tissue expression)LAMTOR3
Human Protein AtlasENSG00000109270-LAMTOR3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHA4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHA4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHA4
PhosPhoSitePlusQ9UHA4
Domains : Interpro (EBI)LAMTOR3   
Domain families : Pfam (Sanger)MAPKK1_Int (PF08923)   
Domain families : Pfam (NCBI)pfam08923   
Domain families : Smart (EMBL)MAPKK1_Int (SM01278)  
Conserved Domain (NCBI)LAMTOR3
PDB (RSDB)1SKO    2ZL1    3CPT    5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
PDB Europe1SKO    2ZL1    3CPT    5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
PDB (PDBSum)1SKO    2ZL1    3CPT    5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
PDB (IMB)1SKO    2ZL1    3CPT    5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
Structural Biology KnowledgeBase1SKO    2ZL1    3CPT    5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
SCOP (Structural Classification of Proteins)1SKO    2ZL1    3CPT    5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
CATH (Classification of proteins structures)1SKO    2ZL1    3CPT    5X6U    5X6V    5Y39    5Y3A    6B9X    6EHP    6EHR    6NZD    6U62    6ULG    6WJ2    6WJ3   
SuperfamilyQ9UHA4
AlphaFold pdb e-kbQ9UHA4   
Human Protein Atlas [tissue]ENSG00000109270-LAMTOR3 [tissue]
HPRD04485
Protein Interaction databases
DIP (DOE-UCLA)Q9UHA4
IntAct (EBI)Q9UHA4
BioGRIDLAMTOR3
STRING (EMBL)LAMTOR3
ZODIACLAMTOR3
Ontologies - Pathways
QuickGOQ9UHA4
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  guanyl-nucleotide exchange factor activity  protein binding  lysosomal membrane  plasma membrane  focal adhesion  endosome membrane  regulation of macroautophagy  kinase activator activity  positive regulation of TOR signaling  positive regulation of TOR signaling  cellular response to amino acid starvation  cellular protein localization  specific granule membrane  neutrophil degranulation  molecular adaptor activity  extracellular exosome  tertiary granule membrane  cellular response to amino acid stimulus  cellular response to amino acid stimulus  Ragulator complex  Ragulator complex  protein localization to cell junction  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  guanyl-nucleotide exchange factor activity  protein binding  lysosomal membrane  plasma membrane  focal adhesion  endosome membrane  regulation of macroautophagy  kinase activator activity  positive regulation of TOR signaling  positive regulation of TOR signaling  cellular response to amino acid starvation  cellular protein localization  specific granule membrane  neutrophil degranulation  molecular adaptor activity  extracellular exosome  tertiary granule membrane  cellular response to amino acid stimulus  cellular response to amino acid stimulus  Ragulator complex  Ragulator complex  protein localization to cell junction  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkLAMTOR3
Atlas of Cancer Signalling NetworkLAMTOR3
Wikipedia pathwaysLAMTOR3
Orthology - Evolution
OrthoDB8649
GeneTree (enSembl)ENSG00000109270
Phylogenetic Trees/Animal Genes : TreeFamLAMTOR3
Homologs : HomoloGeneLAMTOR3
Homology/Alignments : Family Browser (UCSC)LAMTOR3
Gene fusions - Rearrangements
Fusion : QuiverLAMTOR3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAMTOR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAMTOR3
dbVarLAMTOR3
ClinVarLAMTOR3
MonarchLAMTOR3
1000_GenomesLAMTOR3 
Exome Variant ServerLAMTOR3
GNOMAD BrowserENSG00000109270
Varsome BrowserLAMTOR3
ACMGLAMTOR3 variants
VarityQ9UHA4
Genomic Variants (DGV)LAMTOR3 [DGVbeta]
DECIPHERLAMTOR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAMTOR3 
Mutations
ICGC Data PortalLAMTOR3 
TCGA Data PortalLAMTOR3 
Broad Tumor PortalLAMTOR3
OASIS PortalLAMTOR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAMTOR3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLAMTOR3
Mutations and Diseases : HGMDLAMTOR3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLAMTOR3
DgiDB (Drug Gene Interaction Database)LAMTOR3
DoCM (Curated mutations)LAMTOR3
CIViC (Clinical Interpretations of Variants in Cancer)LAMTOR3
Cancer3DLAMTOR3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603296   
Orphanet
DisGeNETLAMTOR3
MedgenLAMTOR3
Genetic Testing Registry LAMTOR3
NextProtQ9UHA4 [Medical]
GENETestsLAMTOR3
Target ValidationLAMTOR3
Huge Navigator LAMTOR3 [HugePedia]
ClinGenLAMTOR3
Clinical trials, drugs, therapy
MyCancerGenomeLAMTOR3
Protein Interactions : CTDLAMTOR3
Pharm GKB GenePA164722189
PharosQ9UHA4
Clinical trialLAMTOR3
Miscellaneous
canSAR (ICR)LAMTOR3
HarmonizomeLAMTOR3
DataMed IndexLAMTOR3
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLAMTOR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:15:34 CEST 2021

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