Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

LAP3 (leucine aminopeptidase 3)

Identity

Alias_namesPEPS
peptidase S
Alias_symbol (synonym)LAPEP
LAP
Other aliasHEL-S-106
HGNC (Hugo) LAP3
LocusID (NCBI) 51056
Atlas_Id 54993
Location 4p15.32  [Link to chromosome band 4p15]
Location_base_pair Starts at 17577304 and ends at 17607967 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LAP3 (4p15.32) / DDX1 (2p24.3)LAP3 (4p15.32) / LAP3 (4p15.32)LAP3 (4p15.32) / REPS2 (Xp22.2)
LAP3 (4p15.32) / SERPINA1 (14q32.13)NTRK2 (9q21.33) / LAP3 (4p15.32)LAP3 4p15.32 / DDX1 2p24.3
NTRK2 9q21.33 / LAP3 4p15.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LAP3   18449
Cards
Entrez_Gene (NCBI)LAP3  51056  leucine aminopeptidase 3
AliasesHEL-S-106; LAP; LAPEP; PEPS
GeneCards (Weizmann)LAP3
Ensembl hg19 (Hinxton)ENSG00000002549 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000002549 [Gene_View]  chr4:17577304-17607967 [Contig_View]  LAP3 [Vega]
ICGC DataPortalENSG00000002549
TCGA cBioPortalLAP3
AceView (NCBI)LAP3
Genatlas (Paris)LAP3
WikiGenes51056
SOURCE (Princeton)LAP3
Genetics Home Reference (NIH)LAP3
Genomic and cartography
GoldenPath hg38 (UCSC)LAP3  -     chr4:17577304-17607967 +  4p15.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAP3  -     4p15.32   [Description]    (hg19-Feb_2009)
EnsemblLAP3 - 4p15.32 [CytoView hg19]  LAP3 - 4p15.32 [CytoView hg38]
Mapping of homologs : NCBILAP3 [Mapview hg19]  LAP3 [Mapview hg38]
OMIM170250   
Gene and transcription
Genbank (Entrez)AF061738 AK022055 AK130293 AK225511 AK298613
RefSeq transcript (Entrez)NM_015907
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LAP3
Cluster EST : UnigeneHs.570791 [ NCBI ]
CGAP (NCI)Hs.570791
Alternative Splicing GalleryENSG00000002549
Gene ExpressionLAP3 [ NCBI-GEO ]   LAP3 [ EBI - ARRAY_EXPRESS ]   LAP3 [ SEEK ]   LAP3 [ MEM ]
Gene Expression Viewer (FireBrowse)LAP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51056
GTEX Portal (Tissue expression)LAP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28838   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28838  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28838
Splice isoforms : SwissVarP28838
Catalytic activity : Enzyme3.4.11.1 [ Enzyme-Expasy ]   3.4.11.13.4.11.1 [ IntEnz-EBI ]   3.4.11.1 [ BRENDA ]   3.4.11.1 [ KEGG ]   
PhosPhoSitePlusP28838
Domaine pattern : Prosite (Expaxy)CYTOSOL_AP (PS00631)   
Domains : Interpro (EBI)Leucine_aapep/pepB    Peptidase_M17_C    Peptidase_M17_leu_NH2_pept    Peptidase_M17_N   
Domain families : Pfam (Sanger)Peptidase_M17 (PF00883)    Peptidase_M17_N (PF02789)   
Domain families : Pfam (NCBI)pfam00883    pfam02789   
Conserved Domain (NCBI)LAP3
DMDM Disease mutations51056
Blocks (Seattle)LAP3
SuperfamilyP28838
Human Protein AtlasENSG00000002549
Peptide AtlasP28838
HPRD07516
IPIIPI00419237   IPI00789806   IPI00967898   IPI00963851   
Protein Interaction databases
DIP (DOE-UCLA)P28838
IntAct (EBI)P28838
FunCoupENSG00000002549
BioGRIDLAP3
STRING (EMBL)LAP3
ZODIACLAP3
Ontologies - Pathways
QuickGOP28838
Ontology : AmiGOaminopeptidase activity  nucleus  nucleoplasm  mitochondrion  trans-Golgi network  cytosol  focal adhesion  proteolysis  metalloexopeptidase activity  manganese ion binding  midbody  extracellular exosome  
Ontology : EGO-EBIaminopeptidase activity  nucleus  nucleoplasm  mitochondrion  trans-Golgi network  cytosol  focal adhesion  proteolysis  metalloexopeptidase activity  manganese ion binding  midbody  extracellular exosome  
Pathways : KEGGArginine and proline metabolism    Glutathione metabolism   
NDEx NetworkLAP3
Atlas of Cancer Signalling NetworkLAP3
Wikipedia pathwaysLAP3
Orthology - Evolution
OrthoDB51056
GeneTree (enSembl)ENSG00000002549
Phylogenetic Trees/Animal Genes : TreeFamLAP3
HOVERGENP28838
HOGENOMP28838
Homologs : HomoloGeneLAP3
Homology/Alignments : Family Browser (UCSC)LAP3
Gene fusions - Rearrangements
Fusion : MitelmanLAP3/DDX1 [4p15.32/2p24.3]  
Fusion : MitelmanNTRK2/LAP3 [9q21.33/4p15.32]  [t(4;9)(p15;q21)]  
Fusion: TCGALAP3 4p15.32 DDX1 2p24.3 BLCA
Fusion: TCGANTRK2 9q21.33 LAP3 4p15.32 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAP3
dbVarLAP3
ClinVarLAP3
1000_GenomesLAP3 
Exome Variant ServerLAP3
ExAC (Exome Aggregation Consortium)LAP3 (select the gene name)
Genetic variants : HAPMAP51056
Genomic Variants (DGV)LAP3 [DGVbeta]
DECIPHERLAP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAP3 
Mutations
ICGC Data PortalLAP3 
TCGA Data PortalLAP3 
Broad Tumor PortalLAP3
OASIS PortalLAP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLAP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LAP3
DgiDB (Drug Gene Interaction Database)LAP3
DoCM (Curated mutations)LAP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAP3 (select a term)
intoGenLAP3
Cancer3DLAP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM170250   
Orphanet
MedgenLAP3
Genetic Testing Registry LAP3
NextProtP28838 [Medical]
TSGene51056
GENETestsLAP3
Target ValidationLAP3
Huge Navigator LAP3 [HugePedia]
snp3D : Map Gene to Disease51056
BioCentury BCIQLAP3
ClinGenLAP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51056
Chemical/Pharm GKB GenePA38537
Clinical trialLAP3
Miscellaneous
canSAR (ICR)LAP3 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAP3
EVEXLAP3
GoPubMedLAP3
iHOPLAP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:40:13 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.