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LAPTM4A (lysosomal protein transmembrane 4 alpha)

Identity

Alias (NCBI)HUMORF13
LAPTM4
MBNT
Mtrp
HGNC (Hugo) LAPTM4A
HGNC Alias symbHUMORF13
KIAA0108
Mtrp
LAPTM4
HGNC Previous nameMBNT
HGNC Previous namelysosomal-associated protein transmembrane 4 alpha
LocusID (NCBI) 9741
Atlas_Id 65172
Location 2p24.1  [Link to chromosome band 2p24]
Location_base_pair Starts at 20032650 and ends at 20051628 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAPN2 (1q41) / LAPTM4A (2p24.1)EIF4G3 (1p36.12) / LAPTM4A (2p24.1)LAPTM4A (2p24.1) / BAZ2B (2q24.2)
LAPTM4A (2p24.1) / DHDDS (1p36.11)LAPTM4A (2p24.1) / GNAS (20q13.32)LAPTM4A (2p24.1) / NACC1 (19p13.2)
LAPTM4A (2p24.1) / NMD3 (3q26.1)LAPTM4A (2p24.1) / SDC1 (2p24.1)RAI14 (5p13.2) / LAPTM4A (2p24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(2;2)(p24;p25) RNF144A/LAPTM4A
t(2;2)(p24;p25) RNF144A/LAPTM4A


External links

 

Nomenclature
HGNC (Hugo)LAPTM4A   6924
Cards
Entrez_Gene (NCBI)LAPTM4A    lysosomal protein transmembrane 4 alpha
AliasesHUMORF13; LAPTM4; MBNT; Mtrp
GeneCards (Weizmann)LAPTM4A
Ensembl hg19 (Hinxton)ENSG00000068697 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000068697 [Gene_View]  ENSG00000068697 [Sequence]  chr2:20032650-20051628 [Contig_View]  LAPTM4A [Vega]
ICGC DataPortalENSG00000068697
TCGA cBioPortalLAPTM4A
AceView (NCBI)LAPTM4A
Genatlas (Paris)LAPTM4A
SOURCE (Princeton)LAPTM4A
Genetics Home Reference (NIH)LAPTM4A
Genomic and cartography
GoldenPath hg38 (UCSC)LAPTM4A  -     chr2:20032650-20051628 -  2p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAPTM4A  -     2p24.1   [Description]    (hg19-Feb_2009)
GoldenPathLAPTM4A - 2p24.1 [CytoView hg19]  LAPTM4A - 2p24.1 [CytoView hg38]
ImmunoBaseENSG00000068697
Genome Data Viewer NCBILAPTM4A [Mapview hg19]  
OMIM618837   
Gene and transcription
Genbank (Entrez)AK129875 AK304433 AY359028 BC000421 BC003158
RefSeq transcript (Entrez)NM_014713
Consensus coding sequences : CCDS (NCBI)LAPTM4A
Gene ExpressionLAPTM4A [ NCBI-GEO ]   LAPTM4A [ EBI - ARRAY_EXPRESS ]   LAPTM4A [ SEEK ]   LAPTM4A [ MEM ]
Gene Expression Viewer (FireBrowse)LAPTM4A [ Firebrowse - Broad ]
GenevisibleExpression of LAPTM4A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9741
GTEX Portal (Tissue expression)LAPTM4A
Human Protein AtlasENSG00000068697-LAPTM4A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15012   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15012  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15012
PhosPhoSitePlusQ15012
Domains : Interpro (EBI)LAPTM4/5    LAPTM_4A/5   
Domain families : Pfam (Sanger)Mtp (PF03821)   
Domain families : Pfam (NCBI)pfam03821   
Conserved Domain (NCBI)LAPTM4A
SuperfamilyQ15012
AlphaFold pdb e-kbQ15012   
Human Protein Atlas [tissue]ENSG00000068697-LAPTM4A [tissue]
HPRD13959
Protein Interaction databases
DIP (DOE-UCLA)Q15012
IntAct (EBI)Q15012
BioGRIDLAPTM4A
STRING (EMBL)LAPTM4A
ZODIACLAPTM4A
Ontologies - Pathways
QuickGOQ15012
Ontology : AmiGOprotein binding  lysosomal membrane  lysosomal membrane  Golgi apparatus  integral component of membrane  late endosome membrane  
Ontology : EGO-EBIprotein binding  lysosomal membrane  lysosomal membrane  Golgi apparatus  integral component of membrane  late endosome membrane  
NDEx NetworkLAPTM4A
Atlas of Cancer Signalling NetworkLAPTM4A
Wikipedia pathwaysLAPTM4A
Orthology - Evolution
OrthoDB9741
GeneTree (enSembl)ENSG00000068697
Phylogenetic Trees/Animal Genes : TreeFamLAPTM4A
Homologs : HomoloGeneLAPTM4A
Homology/Alignments : Family Browser (UCSC)LAPTM4A
Gene fusions - Rearrangements
Fusion : QuiverLAPTM4A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAPTM4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAPTM4A
dbVarLAPTM4A
ClinVarLAPTM4A
MonarchLAPTM4A
1000_GenomesLAPTM4A 
Exome Variant ServerLAPTM4A
GNOMAD BrowserENSG00000068697
Varsome BrowserLAPTM4A
ACMGLAPTM4A variants
VarityQ15012
Genomic Variants (DGV)LAPTM4A [DGVbeta]
DECIPHERLAPTM4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAPTM4A 
Mutations
ICGC Data PortalLAPTM4A 
TCGA Data PortalLAPTM4A 
Broad Tumor PortalLAPTM4A
OASIS PortalLAPTM4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAPTM4A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLAPTM4A
Mutations and Diseases : HGMDLAPTM4A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLAPTM4A
DgiDB (Drug Gene Interaction Database)LAPTM4A
DoCM (Curated mutations)LAPTM4A
CIViC (Clinical Interpretations of Variants in Cancer)LAPTM4A
Cancer3DLAPTM4A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618837   
Orphanet
DisGeNETLAPTM4A
MedgenLAPTM4A
Genetic Testing Registry LAPTM4A
NextProtQ15012 [Medical]
GENETestsLAPTM4A
Target ValidationLAPTM4A
Huge Navigator LAPTM4A [HugePedia]
ClinGenLAPTM4A
Clinical trials, drugs, therapy
MyCancerGenomeLAPTM4A
Protein Interactions : CTDLAPTM4A
Pharm GKB GenePA30295
PharosQ15012
Clinical trialLAPTM4A
Miscellaneous
canSAR (ICR)LAPTM4A
HarmonizomeLAPTM4A
DataMed IndexLAPTM4A
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLAPTM4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:55:24 CEST 2021

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