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LAPTM4A (lysosomal protein transmembrane 4 alpha)

Identity

Alias_namesMBNT
lysosomal-associated protein transmembrane 4 alpha
Alias_symbol (synonym)HUMORF13
KIAA0108
Mtrp
LAPTM4
Other alias
HGNC (Hugo) LAPTM4A
LocusID (NCBI) 9741
Atlas_Id 65172
Location 2p24.1  [Link to chromosome band 2p24]
Location_base_pair Starts at 20032650 and ends at 20052028 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAPN2 (1q41) / LAPTM4A (2p24.1)EIF4G3 (1p36.12) / LAPTM4A (2p24.1)LAPTM4A (2p24.1) / BAZ2B (2q24.2)
LAPTM4A (2p24.1) / DHDDS (1p36.11)LAPTM4A (2p24.1) / GNAS (20q13.32)LAPTM4A (2p24.1) / NACC1 (19p13.2)
LAPTM4A (2p24.1) / NMD3 (3q26.1)LAPTM4A (2p24.1) / SDC1 (2p24.1)RAI14 (5p13.2) / LAPTM4A (2p24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LAPTM4A   6924
Cards
Entrez_Gene (NCBI)LAPTM4A  9741  lysosomal protein transmembrane 4 alpha
AliasesHUMORF13; LAPTM4; MBNT; Mtrp
GeneCards (Weizmann)LAPTM4A
Ensembl hg19 (Hinxton)ENSG00000068697 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000068697 [Gene_View]  chr2:20032650-20052028 [Contig_View]  LAPTM4A [Vega]
ICGC DataPortalENSG00000068697
TCGA cBioPortalLAPTM4A
AceView (NCBI)LAPTM4A
Genatlas (Paris)LAPTM4A
WikiGenes9741
SOURCE (Princeton)LAPTM4A
Genetics Home Reference (NIH)LAPTM4A
Genomic and cartography
GoldenPath hg38 (UCSC)LAPTM4A  -     chr2:20032650-20052028 -  2p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAPTM4A  -     2p24.1   [Description]    (hg19-Feb_2009)
EnsemblLAPTM4A - 2p24.1 [CytoView hg19]  LAPTM4A - 2p24.1 [CytoView hg38]
Mapping of homologs : NCBILAPTM4A [Mapview hg19]  LAPTM4A [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK129875 AK304433 AY359028 BC000421 BC003158
RefSeq transcript (Entrez)NM_014713
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LAPTM4A
Cluster EST : UnigeneHs.467807 [ NCBI ]
CGAP (NCI)Hs.467807
Alternative Splicing GalleryENSG00000068697
Gene ExpressionLAPTM4A [ NCBI-GEO ]   LAPTM4A [ EBI - ARRAY_EXPRESS ]   LAPTM4A [ SEEK ]   LAPTM4A [ MEM ]
Gene Expression Viewer (FireBrowse)LAPTM4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9741
GTEX Portal (Tissue expression)LAPTM4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15012   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15012  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15012
Splice isoforms : SwissVarQ15012
PhosPhoSitePlusQ15012
Domains : Interpro (EBI)LAPTM4/5    LAPTM_4A/5   
Domain families : Pfam (Sanger)Mtp (PF03821)   
Domain families : Pfam (NCBI)pfam03821   
Conserved Domain (NCBI)LAPTM4A
DMDM Disease mutations9741
Blocks (Seattle)LAPTM4A
SuperfamilyQ15012
Human Protein AtlasENSG00000068697
Peptide AtlasQ15012
HPRD13959
IPIIPI00014172   
Protein Interaction databases
DIP (DOE-UCLA)Q15012
IntAct (EBI)Q15012
FunCoupENSG00000068697
BioGRIDLAPTM4A
STRING (EMBL)LAPTM4A
ZODIACLAPTM4A
Ontologies - Pathways
QuickGOQ15012
Ontology : AmiGOGolgi apparatus  transport  integral component of membrane  
Ontology : EGO-EBIGolgi apparatus  transport  integral component of membrane  
Pathways : KEGGLysosome   
NDEx NetworkLAPTM4A
Atlas of Cancer Signalling NetworkLAPTM4A
Wikipedia pathwaysLAPTM4A
Orthology - Evolution
OrthoDB9741
GeneTree (enSembl)ENSG00000068697
Phylogenetic Trees/Animal Genes : TreeFamLAPTM4A
HOVERGENQ15012
HOGENOMQ15012
Homologs : HomoloGeneLAPTM4A
Homology/Alignments : Family Browser (UCSC)LAPTM4A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAPTM4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAPTM4A
dbVarLAPTM4A
ClinVarLAPTM4A
1000_GenomesLAPTM4A 
Exome Variant ServerLAPTM4A
ExAC (Exome Aggregation Consortium)LAPTM4A (select the gene name)
Genetic variants : HAPMAP9741
Genomic Variants (DGV)LAPTM4A [DGVbeta]
DECIPHERLAPTM4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAPTM4A 
Mutations
ICGC Data PortalLAPTM4A 
TCGA Data PortalLAPTM4A 
Broad Tumor PortalLAPTM4A
OASIS PortalLAPTM4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAPTM4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLAPTM4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAPTM4A
DgiDB (Drug Gene Interaction Database)LAPTM4A
DoCM (Curated mutations)LAPTM4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAPTM4A (select a term)
intoGenLAPTM4A
Cancer3DLAPTM4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenLAPTM4A
Genetic Testing Registry LAPTM4A
NextProtQ15012 [Medical]
TSGene9741
GENETestsLAPTM4A
Target ValidationLAPTM4A
Huge Navigator LAPTM4A [HugePedia]
snp3D : Map Gene to Disease9741
BioCentury BCIQLAPTM4A
ClinGenLAPTM4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9741
Chemical/Pharm GKB GenePA30295
Clinical trialLAPTM4A
Miscellaneous
canSAR (ICR)LAPTM4A (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAPTM4A
EVEXLAPTM4A
GoPubMedLAPTM4A
iHOPLAPTM4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:12:30 CEST 2017

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