Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

LAPTM4B (lysosomal protein transmembrane 4 beta)

Identity

Alias_symbol (synonym)LC27
Other aliasLAPTM4beta
HGNC (Hugo) LAPTM4B
LocusID (NCBI) 55353
Atlas_Id 43622
Location 8q22.1  [Link to chromosome band 8q22]
Location_base_pair Starts at 97775581 and ends at 97852602 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRP12 (8q22.3) / LAPTM4B (8q22.1)NCALD (8q22.3) / LAPTM4B (8q22.1)VPS13B (8q22.2) / LAPTM4B (8q22.1)
LRP12 8q22.3 / LAPTM4B 8q22.1NCALD 8q22.3 / LAPTM4B 8q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LAPTM4B   13646
Cards
Entrez_Gene (NCBI)LAPTM4B  55353  lysosomal protein transmembrane 4 beta
AliasesLAPTM4beta; LC27
GeneCards (Weizmann)LAPTM4B
Ensembl hg19 (Hinxton)ENSG00000104341 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104341 [Gene_View]  chr8:97775581-97852602 [Contig_View]  LAPTM4B [Vega]
ICGC DataPortalENSG00000104341
TCGA cBioPortalLAPTM4B
AceView (NCBI)LAPTM4B
Genatlas (Paris)LAPTM4B
WikiGenes55353
SOURCE (Princeton)LAPTM4B
Genetics Home Reference (NIH)LAPTM4B
Genomic and cartography
GoldenPath hg38 (UCSC)LAPTM4B  -     chr8:97775581-97852602 +  8q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAPTM4B  -     8q22.1   [Description]    (hg19-Feb_2009)
EnsemblLAPTM4B - 8q22.1 [CytoView hg19]  LAPTM4B - 8q22.1 [CytoView hg38]
Mapping of homologs : NCBILAPTM4B [Mapview hg19]  LAPTM4B [Mapview hg38]
OMIM613296   
Gene and transcription
Genbank (Entrez)AF317417 AF527412 AI079853 AK075326 AK311377
RefSeq transcript (Entrez)NM_018407
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LAPTM4B
Cluster EST : UnigeneHs.492314 [ NCBI ]
CGAP (NCI)Hs.492314
Alternative Splicing GalleryENSG00000104341
Gene ExpressionLAPTM4B [ NCBI-GEO ]   LAPTM4B [ EBI - ARRAY_EXPRESS ]   LAPTM4B [ SEEK ]   LAPTM4B [ MEM ]
Gene Expression Viewer (FireBrowse)LAPTM4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55353
GTEX Portal (Tissue expression)LAPTM4B
Human Protein AtlasENSG00000104341-LAPTM4B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VI4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VI4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VI4
Splice isoforms : SwissVarQ86VI4
PhosPhoSitePlusQ86VI4
Domains : Interpro (EBI)LAPTM4/5    Lysosomal-assoc_TM_prot4B   
Domain families : Pfam (Sanger)Mtp (PF03821)   
Domain families : Pfam (NCBI)pfam03821   
Conserved Domain (NCBI)LAPTM4B
DMDM Disease mutations55353
Blocks (Seattle)LAPTM4B
SuperfamilyQ86VI4
Human Protein Atlas [tissue]ENSG00000104341-LAPTM4B [tissue]
Peptide AtlasQ86VI4
IPIIPI00465172   IPI00743046   IPI00786974   IPI00978586   
Protein Interaction databases
DIP (DOE-UCLA)Q86VI4
IntAct (EBI)Q86VI4
FunCoupENSG00000104341
BioGRIDLAPTM4B
STRING (EMBL)LAPTM4B
ZODIACLAPTM4B
Ontologies - Pathways
QuickGOQ86VI4
Ontology : AmiGOprotein binding  transport  endomembrane system  integral component of membrane  
Ontology : EGO-EBIprotein binding  transport  endomembrane system  integral component of membrane  
Pathways : KEGGLysosome   
NDEx NetworkLAPTM4B
Atlas of Cancer Signalling NetworkLAPTM4B
Wikipedia pathwaysLAPTM4B
Orthology - Evolution
OrthoDB55353
GeneTree (enSembl)ENSG00000104341
Phylogenetic Trees/Animal Genes : TreeFamLAPTM4B
HOVERGENQ86VI4
HOGENOMQ86VI4
Homologs : HomoloGeneLAPTM4B
Homology/Alignments : Family Browser (UCSC)LAPTM4B
Gene fusions - Rearrangements
Fusion : MitelmanLRP12/LAPTM4B [8q22.3/8q22.1]  [t(8;8)(q22;q22)]  
Fusion : MitelmanNCALD/LAPTM4B [8q22.3/8q22.1]  [t(8;8)(q22;q22)]  
Fusion: TCGA_MDACCLRP12 8q22.3 LAPTM4B 8q22.1 BRCA
Fusion: TCGA_MDACCNCALD 8q22.3 LAPTM4B 8q22.1 LGG
Tumor Fusion PortalLAPTM4B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAPTM4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAPTM4B
dbVarLAPTM4B
ClinVarLAPTM4B
1000_GenomesLAPTM4B 
Exome Variant ServerLAPTM4B
ExAC (Exome Aggregation Consortium)ENSG00000104341
GNOMAD BrowserENSG00000104341
Genetic variants : HAPMAP55353
Genomic Variants (DGV)LAPTM4B [DGVbeta]
DECIPHERLAPTM4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAPTM4B 
Mutations
ICGC Data PortalLAPTM4B 
TCGA Data PortalLAPTM4B 
Broad Tumor PortalLAPTM4B
OASIS PortalLAPTM4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAPTM4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLAPTM4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAPTM4B
DgiDB (Drug Gene Interaction Database)LAPTM4B
DoCM (Curated mutations)LAPTM4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAPTM4B (select a term)
intoGenLAPTM4B
Cancer3DLAPTM4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613296   
Orphanet
DisGeNETLAPTM4B
MedgenLAPTM4B
Genetic Testing Registry LAPTM4B
NextProtQ86VI4 [Medical]
TSGene55353
GENETestsLAPTM4B
Target ValidationLAPTM4B
Huge Navigator LAPTM4B [HugePedia]
snp3D : Map Gene to Disease55353
BioCentury BCIQLAPTM4B
ClinGenLAPTM4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55353
Chemical/Pharm GKB GenePA128395785
Clinical trialLAPTM4B
Miscellaneous
canSAR (ICR)LAPTM4B (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAPTM4B
EVEXLAPTM4B
GoPubMedLAPTM4B
iHOPLAPTM4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:19:32 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.