Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

LAPTM5 (lysosomal protein transmembrane 5)

Identity

Alias (NCBI)CLAST6
HGNC (Hugo) LAPTM5
HGNC Previous namelysosomal multispanning membrane protein 5
LocusID (NCBI) 7805
Atlas_Id 53018
Location 1p35.2  [Link to chromosome band 1p35]
Location_base_pair Starts at 30732469 and ends at 30757774 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LAPTM5 (1p35.2) / AFAP1L1 (5q32)LAPTM5 (1p35.2) / CD82 (11p11.2)LAPTM5 (1p35.2) / GRID2IP (7p22.1)
LAPTM5 (1p35.2) / JADE3 (Xp11.23)LAPTM5 (1p35.2) / POR (7q11.23)LAPTM5 (1p35.2) / ZBTB20 (3q13.31)
MFSD2A (1p34.2) / LAPTM5 (1p35.2)SNORA63 (3q27.3) / LAPTM5 (1p35.2)MFSD2A 1p34.2 / LAPTM5 1p35.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;14)(p35;q32) LAPTM5/IGH

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(p34;p35) MFSD2A/LAPTM5

External links

Nomenclature
HGNC (Hugo)LAPTM5   29612
Cards
Entrez_Gene (NCBI)LAPTM5    lysosomal protein transmembrane 5
AliasesCLAST6
GeneCards (Weizmann)LAPTM5
Ensembl hg19 (Hinxton)ENSG00000162511 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162511 [Gene_View]  ENSG00000162511 [Sequence]  chr1:30732469-30757774 [Contig_View]  LAPTM5 [Vega]
ICGC DataPortalENSG00000162511
TCGA cBioPortalLAPTM5
AceView (NCBI)LAPTM5
Genatlas (Paris)LAPTM5
SOURCE (Princeton)LAPTM5
Genetics Home Reference (NIH)LAPTM5
Genomic and cartography
GoldenPath hg38 (UCSC)LAPTM5  -     chr1:30732469-30757774 -  1p35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAPTM5  -     1p35.2   [Description]    (hg19-Feb_2009)
GoldenPathLAPTM5 - 1p35.2 [CytoView hg19]  LAPTM5 - 1p35.2 [CytoView hg38]
ImmunoBaseENSG00000162511
genome Data Viewer NCBILAPTM5 [Mapview hg19]  
OMIM601476   
Gene and transcription
Genbank (Entrez)AF401210 AK292009 AK297014 BC106896 BC106897
RefSeq transcript (Entrez)NM_006762
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LAPTM5
Alternative Splicing GalleryENSG00000162511
Gene ExpressionLAPTM5 [ NCBI-GEO ]   LAPTM5 [ EBI - ARRAY_EXPRESS ]   LAPTM5 [ SEEK ]   LAPTM5 [ MEM ]
Gene Expression Viewer (FireBrowse)LAPTM5 [ Firebrowse - Broad ]
GenevisibleExpression of LAPTM5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7805
GTEX Portal (Tissue expression)LAPTM5
Human Protein AtlasENSG00000162511-LAPTM5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13571   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13571  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13571
Splice isoforms : SwissVarQ13571
PhosPhoSitePlusQ13571
Domains : Interpro (EBI)LAPTM4/5    LAPTM_4A/5    Lysosomal-assoc_TM_prot5   
Domain families : Pfam (Sanger)Mtp (PF03821)   
Domain families : Pfam (NCBI)pfam03821   
Conserved Domain (NCBI)LAPTM5
Blocks (Seattle)LAPTM5
SuperfamilyQ13571
Human Protein Atlas [tissue]ENSG00000162511-LAPTM5 [tissue]
Peptide AtlasQ13571
HPRD03280
IPIIPI00013827   IPI00910991   
Protein Interaction databases
DIP (DOE-UCLA)Q13571
IntAct (EBI)Q13571
BioGRIDLAPTM5
STRING (EMBL)LAPTM5
ZODIACLAPTM5
Ontologies - Pathways
QuickGOQ13571
Ontology : AmiGOprotein binding  lysosome  lysosomal membrane  integral component of plasma membrane  cellular response to leukemia inhibitory factor  
Ontology : EGO-EBIprotein binding  lysosome  lysosomal membrane  integral component of plasma membrane  cellular response to leukemia inhibitory factor  
Pathways : KEGGLysosome   
NDEx NetworkLAPTM5
Atlas of Cancer Signalling NetworkLAPTM5
Wikipedia pathwaysLAPTM5
Orthology - Evolution
OrthoDB7805
GeneTree (enSembl)ENSG00000162511
Phylogenetic Trees/Animal Genes : TreeFamLAPTM5
HOGENOMQ13571
Homologs : HomoloGeneLAPTM5
Homology/Alignments : Family Browser (UCSC)LAPTM5
Gene fusions - Rearrangements
Fusion : MitelmanMFSD2A/LAPTM5 [1p34.2/1p35.2]  
Fusion PortalMFSD2A 1p34.2 LAPTM5 1p35.2 LGG
Fusion Cancer (Beijing)LAPTM5 [1p35.2]  -  GRID2IP [7p22.1]  [FUSC002423]
Fusion : QuiverLAPTM5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAPTM5 [hg38]
dbVarLAPTM5
ClinVarLAPTM5
MonarchLAPTM5
1000_GenomesLAPTM5 
Exome Variant ServerLAPTM5
GNOMAD BrowserENSG00000162511
Varsome BrowserLAPTM5
Genomic Variants (DGV)LAPTM5 [DGVbeta]
DECIPHERLAPTM5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAPTM5 
Mutations
ICGC Data PortalLAPTM5 
TCGA Data PortalLAPTM5 
Broad Tumor PortalLAPTM5
OASIS PortalLAPTM5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAPTM5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLAPTM5
Mutations and Diseases : HGMDLAPTM5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAPTM5
DgiDB (Drug Gene Interaction Database)LAPTM5
DoCM (Curated mutations)LAPTM5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAPTM5 (select a term)
intoGenLAPTM5
Cancer3DLAPTM5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601476   
Orphanet
DisGeNETLAPTM5
MedgenLAPTM5
Genetic Testing Registry LAPTM5
NextProtQ13571 [Medical]
GENETestsLAPTM5
Target ValidationLAPTM5
Huge Navigator LAPTM5 [HugePedia]
ClinGenLAPTM5
Clinical trials, drugs, therapy
MyCancerGenomeLAPTM5
Protein Interactions : CTD
Pharm GKB GenePA134953439
PharosQ13571
Clinical trialLAPTM5
Miscellaneous
canSAR (ICR)LAPTM5 (select the gene name)
HarmonizomeLAPTM5
DataMed IndexLAPTM5
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLAPTM5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:21:57 CET 2021
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.