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LARGE2 (LARGE xylosyl- and glucuronyltransferase 2)

Identity

Alias_namesGYLTL1B
glycosyltransferase-like 1B
Alias_symbol (synonym)PP5656
FLJ35207
Other alias
HGNC (Hugo) LARGE2
LocusID (NCBI) 120071
Atlas_Id 55818
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 45921621 and ends at 45929096 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LARGE2   16522
Cards
Entrez_Gene (NCBI)LARGE2  120071  LARGE xylosyl- and glucuronyltransferase 2
AliasesGYLTL1B; PP5656
GeneCards (Weizmann)LARGE2
Ensembl hg19 (Hinxton)ENSG00000165905 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165905 [Gene_View]  ENSG00000165905 [Sequence]  chr11:45921621-45929096 [Contig_View]  LARGE2 [Vega]
ICGC DataPortalENSG00000165905
TCGA cBioPortalLARGE2
AceView (NCBI)LARGE2
Genatlas (Paris)LARGE2
WikiGenes120071
SOURCE (Princeton)LARGE2
Genetics Home Reference (NIH)LARGE2
Genomic and cartography
GoldenPath hg38 (UCSC)LARGE2  -     chr11:45921621-45929096 +  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LARGE2  -     11p11.2   [Description]    (hg19-Feb_2009)
EnsemblLARGE2 - 11p11.2 [CytoView hg19]  LARGE2 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBILARGE2 [Mapview hg19]  LARGE2 [Mapview hg38]
OMIM609709   
Gene and transcription
Genbank (Entrez)AF258588 AK055829 AK092526 AK096021 BC037291
RefSeq transcript (Entrez)NM_001300721 NM_001300722 NM_152312
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LARGE2
Cluster EST : UnigeneHs.86543 [ NCBI ]
CGAP (NCI)Hs.86543
Alternative Splicing GalleryENSG00000165905
Gene ExpressionLARGE2 [ NCBI-GEO ]   LARGE2 [ EBI - ARRAY_EXPRESS ]   LARGE2 [ SEEK ]   LARGE2 [ MEM ]
Gene Expression Viewer (FireBrowse)LARGE2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)120071
GTEX Portal (Tissue expression)LARGE2
Human Protein AtlasENSG00000165905-LARGE2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N3Y3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N3Y3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N3Y3
Splice isoforms : SwissVarQ8N3Y3
Catalytic activity : Enzyme2.4.-.- [ Enzyme-Expasy ]   2.4.-.-2.4.-.- [ IntEnz-EBI ]   2.4.-.- [ BRENDA ]   2.4.-.- [ KEGG ]   
PhosPhoSitePlusQ8N3Y3
Domains : Interpro (EBI)Glyco_trans_8    Nucleotide-diphossugar_trans   
Domain families : Pfam (Sanger)Glyco_transf_8 (PF01501)   
Domain families : Pfam (NCBI)pfam01501   
Conserved Domain (NCBI)LARGE2
DMDM Disease mutations120071
Blocks (Seattle)LARGE2
SuperfamilyQ8N3Y3
Human Protein Atlas [tissue]ENSG00000165905-LARGE2 [tissue]
Peptide AtlasQ8N3Y3
HPRD13618
IPIIPI00298417   IPI00783334   IPI00978423   IPI00984180   IPI00978135   IPI00977599   
Protein Interaction databases
DIP (DOE-UCLA)Q8N3Y3
IntAct (EBI)Q8N3Y3
FunCoupENSG00000165905
BioGRIDLARGE2
STRING (EMBL)LARGE2
ZODIACLARGE2
Ontologies - Pathways
QuickGOQ8N3Y3
Ontology : AmiGOGolgi membrane  protein binding  protein O-linked glycosylation  glucuronosyltransferase activity  glucuronosyltransferase activity  integral component of membrane  manganese ion binding  UDP-xylosyltransferase activity  protein O-linked mannosylation  xylosyltransferase activity  muscle cell cellular homeostasis  
Ontology : EGO-EBIGolgi membrane  protein binding  protein O-linked glycosylation  glucuronosyltransferase activity  glucuronosyltransferase activity  integral component of membrane  manganese ion binding  UDP-xylosyltransferase activity  protein O-linked mannosylation  xylosyltransferase activity  muscle cell cellular homeostasis  
NDEx NetworkLARGE2
Atlas of Cancer Signalling NetworkLARGE2
Wikipedia pathwaysLARGE2
Orthology - Evolution
OrthoDB120071
GeneTree (enSembl)ENSG00000165905
Phylogenetic Trees/Animal Genes : TreeFamLARGE2
HOVERGENQ8N3Y3
HOGENOMQ8N3Y3
Homologs : HomoloGeneLARGE2
Homology/Alignments : Family Browser (UCSC)LARGE2
Gene fusions - Rearrangements
Fusion : QuiverLARGE2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLARGE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LARGE2
dbVarLARGE2
ClinVarLARGE2
1000_GenomesLARGE2 
Exome Variant ServerLARGE2
ExAC (Exome Aggregation Consortium)ENSG00000165905
GNOMAD BrowserENSG00000165905
Varsome BrowserLARGE2
Genetic variants : HAPMAP120071
Genomic Variants (DGV)LARGE2 [DGVbeta]
DECIPHERLARGE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLARGE2 
Mutations
ICGC Data PortalLARGE2 
TCGA Data PortalLARGE2 
Broad Tumor PortalLARGE2
OASIS PortalLARGE2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDLARGE2
BioMutasearch LARGE2
DgiDB (Drug Gene Interaction Database)LARGE2
DoCM (Curated mutations)LARGE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LARGE2 (select a term)
intoGenLARGE2
Cancer3DLARGE2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609709   
Orphanet
DisGeNETLARGE2
MedgenLARGE2
Genetic Testing Registry LARGE2
NextProtQ8N3Y3 [Medical]
TSGene120071
GENETestsLARGE2
Target ValidationLARGE2
Huge Navigator LARGE2 [HugePedia]
snp3D : Map Gene to Disease120071
BioCentury BCIQLARGE2
ClinGenLARGE2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD120071
Chemical/Pharm GKB GenePA142671704
Clinical trialLARGE2
Miscellaneous
canSAR (ICR)LARGE2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLARGE2
EVEXLARGE2
GoPubMedLARGE2
iHOPLARGE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:31:30 CEST 2018

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