LARP1 (La ribonucleoprotein 1, translational regulator)

2016-01-01  

Identity

HGNC
LARP1
LOCATION
5q33.2
LOCUSID
23367
ALIAS
LARP,Lar1,Lhp1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23367
MIM: 612059
HGNC: 29531
Ensembl: ENSG00000155506

Variants:

dbSNP: 23367
ClinVar: 23367
TCGA: ENSG00000155506
COSMIC: LARP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155506ENST00000336314Q6PKG0
ENSG00000155506ENST00000517616H0YBM7
ENSG00000155506ENST00000518194H0YAN4
ENSG00000155506ENST00000518297A0A0B4J210
ENSG00000155506ENST00000518677H0YC33
ENSG00000155506ENST00000518742H0YC73
ENSG00000155506ENST00000518892H0YBJ5
ENSG00000155506ENST00000519931E5RHK4
ENSG00000155506ENST00000521577H0YAX9
ENSG00000155506ENST00000522272H0YBR8
ENSG00000155506ENST00000523163H0YBW1
ENSG00000155506ENST00000524248E5RH50

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
245327142014Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation.83
259400912015La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).52
150600812004Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA.37
255313182015LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression.29
283791362017La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs.28
237113702013LARP1 specifically recognizes the 3' terminus of poly(A) mRNA.26
260634842015MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer.25
267179852016The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer.24
286507972017LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs.24
292441222018La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region.19

Citation

Dessen P

LARP1 (La ribonucleoprotein 1, translational regulator)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55577/larp1