LARP4 (La ribonucleoprotein 4)

2018-02-01  

Identity

HGNC
LARP4
LOCATION
12q13.12
LOCUSID
113251
ALIAS
PP13296
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 113251
MIM: 618657
HGNC: 24320
Ensembl: ENSG00000161813

Variants:

dbSNP: 113251
ClinVar: 113251
TCGA: ENSG00000161813
COSMIC: LARP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161813ENST00000293618Q71RC2
ENSG00000161813ENST00000347328Q71RC2
ENSG00000161813ENST00000398473Q71RC2
ENSG00000161813ENST00000429001Q71RC2
ENSG00000161813ENST00000517559E5RHZ8
ENSG00000161813ENST00000518444Q71RC2
ENSG00000161813ENST00000518561Q96J85
ENSG00000161813ENST00000520064X6RLN4
ENSG00000161813ENST00000522085Q71RC2
ENSG00000161813ENST00000523389E5RJH8
ENSG00000161813ENST00000548174F8VNV1
ENSG00000161813ENST00000548697F8VXL0
ENSG00000161813ENST00000548993F8W1I4
ENSG00000161813ENST00000550260F8VY40
ENSG00000161813ENST00000550522F8VSA9
ENSG00000161813ENST00000551886F8W1Z5
ENSG00000161813ENST00000552445F8VZ60
ENSG00000161813ENST00000614335Q8TBL5
ENSG00000161813ENST00000615080A0A087WTL9

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
288932652017Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression.132
210981202011La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability.34
287822432017The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.18
238879372013Conservation of RNA chaperone activity of the human La-related proteins 4, 6 and 7.16
276157442016The RNA-binding protein LARP4 regulates cancer cell migration and invasion.16
155722132005Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders.13
288955292017LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection.10
304684592018Circular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis.9
305205392019circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma.8
266444072016LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a Tristetraprolin-Dependent Manner.5

Citation

Dessen P

LARP4 (La ribonucleoprotein 4)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57369/larp4