LARP6 (La ribonucleoprotein 6, translational regulator)

2012-02-01  

Identity

HGNC
LARP6
LOCATION
15q23
LOCUSID
55323
ALIAS
ACHN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55323
MIM: 611300
HGNC: 24012
Ensembl: ENSG00000166173

Variants:

dbSNP: 55323
ClinVar: 55323
TCGA: ENSG00000166173
COSMIC: LARP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166173ENST00000299213Q9BRS8
ENSG00000166173ENST00000344870Q9BRS8
ENSG00000166173ENST00000559140H0YMC6
ENSG00000166173ENST00000559316K7EPD2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199172932010Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen.44
244694592014Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA.26
287822432017The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.18
173831182007Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta.16
238879372013Conservation of RNA chaperone activity of the human La-related proteins 4, 6 and 7.16
254888122015Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.15
269324612016Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen.13
256922372014Characterization of binding of LARP6 to the 5' stem-loop of collagen mRNAs: implications for synthesis of type I collagen.11
252718812014Role of LARP6 and nonmuscle myosin in partitioning of collagen mRNAs to the ER membrane.10
198899612010Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts.7

Citation

Dessen P

LARP6 (La ribonucleoprotein 6, translational regulator)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52603/larp6