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LARS (leucyl-tRNA synthetase)

Identity

Alias_namescytoplasmic
Alias_symbol (synonym)HSPC192
FLJ10595
FLJ21788
LARS1
LEUS
RNTLS
Other aliasILFS1
LEURS
LFIS
LRS
PIG44
hr025Cl
HGNC (Hugo) LARS
LocusID (NCBI) 51520
Atlas_Id 50329
Location 5q32  [Link to chromosome band 5q32]
Location_base_pair Starts at 146113026 and ends at 146182787 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LARS (5q32) / HSP90AA1 (14q32.31)LARS (5q32) / PIGB (15q21.3)LARS (5q32) / WAPL (10q23.2)
PRELID2 (5q32) / LARS (5q32)THSD1 (13q14.3) / LARS (5q32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LARS   6512
Cards
Entrez_Gene (NCBI)LARS  51520  leucyl-tRNA synthetase
AliasesHSPC192; ILFS1; LARS1; LEURS; 
LEUS; LFIS; LRS; PIG44; RNTLS; hr025Cl
GeneCards (Weizmann)LARS
Ensembl hg19 (Hinxton)ENSG00000133706 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133706 [Gene_View]  chr5:146113026-146182787 [Contig_View]  LARS [Vega]
ICGC DataPortalENSG00000133706
TCGA cBioPortalLARS
AceView (NCBI)LARS
Genatlas (Paris)LARS
WikiGenes51520
SOURCE (Princeton)LARS
Genetics Home Reference (NIH)LARS
Genomic and cartography
GoldenPath hg38 (UCSC)LARS  -     chr5:146113026-146182787 -  5q32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LARS  -     5q32   [Description]    (hg19-Feb_2009)
EnsemblLARS - 5q32 [CytoView hg19]  LARS - 5q32 [CytoView hg38]
Mapping of homologs : NCBILARS [Mapview hg19]  LARS [Mapview hg38]
OMIM151350   615438   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001317964 NM_001317965 NM_016460 NM_020117
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LARS
Cluster EST : UnigeneHs.432674 [ NCBI ]
CGAP (NCI)Hs.432674
Alternative Splicing GalleryENSG00000133706
Gene ExpressionLARS [ NCBI-GEO ]   LARS [ EBI - ARRAY_EXPRESS ]   LARS [ SEEK ]   LARS [ MEM ]
Gene Expression Viewer (FireBrowse)LARS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51520
GTEX Portal (Tissue expression)LARS
Human Protein AtlasENSG00000133706-LARS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2J5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2J5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2J5
Splice isoforms : SwissVarQ9P2J5
Catalytic activity : Enzyme6.1.1.4 [ Enzyme-Expasy ]   6.1.1.46.1.1.4 [ IntEnz-EBI ]   6.1.1.4 [ BRENDA ]   6.1.1.4 [ KEGG ]   
PhosPhoSitePlusQ9P2J5
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ia    Leu-tRNA-synth_Ia_arc/euk    M/V/L/I-tRNA-synth_anticd-bd    Rossmann-like_a/b/a_fold    tRNAsynth_Ia_anticodon-bd    Val/Leu/Ile-tRNA-synth_edit   
Domain families : Pfam (Sanger)Anticodon_1 (PF08264)    tRNA-synt_1 (PF00133)   
Domain families : Pfam (NCBI)pfam08264    pfam00133   
Conserved Domain (NCBI)LARS
DMDM Disease mutations51520
Blocks (Seattle)LARS
PDB (SRS)2WFD   
PDB (PDBSum)2WFD   
PDB (IMB)2WFD   
PDB (RSDB)2WFD   
Structural Biology KnowledgeBase2WFD   
SCOP (Structural Classification of Proteins)2WFD   
CATH (Classification of proteins structures)2WFD   
SuperfamilyQ9P2J5
Human Protein Atlas [tissue]ENSG00000133706-LARS [tissue]
Peptide AtlasQ9P2J5
HPRD01042
IPIIPI00103994   IPI01014989   IPI01011719   IPI00965964   IPI01012157   IPI00383290   IPI01014783   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2J5
IntAct (EBI)Q9P2J5
FunCoupENSG00000133706
BioGRIDLARS
STRING (EMBL)LARS
ZODIACLARS
Ontologies - Pathways
QuickGOQ9P2J5
Ontology : AmiGOaminoacyl-tRNA editing activity  leucine-tRNA ligase activity  leucine-tRNA ligase activity  valine-tRNA ligase activity  GTPase activator activity  protein binding  ETp binding  cytoplasm  lysosome  endoplasmic reticulum  cytosol  cytosol  cytosol  tRNA aminoacylation for protein translation  leucyl-tRNA aminoacylation  valyl-tRNA aminoacylation  regulation of translational fidelity  protein targeting to lysosome  regulation of cell size  negative regulation of autophagy  endomembrane system  nuclear body  aminoacyl-tRNA synthetase multienzyme complex  cellular response to amino acid starvation  positive regulation of GTPase activity  cellular response to amino acid stimulus  cellular response to leucine  positive regulation of TORC1 signaling  cellular response to leucine starvation  
Ontology : EGO-EBIaminoacyl-tRNA editing activity  leucine-tRNA ligase activity  leucine-tRNA ligase activity  valine-tRNA ligase activity  GTPase activator activity  protein binding  ATP binding  cytoplasm  lysosome  endoplasmic reticulum  cytosol  cytosol  cytosol  tRNA aminoacylation for protein translation  leucyl-tRNA aminoacylation  valyl-tRNA aminoacylation  regulation of translational fidelity  protein targeting to lysosome  regulation of cell size  negative regulation of autophagy  endomembrane system  nuclear body  aminoacyl-tRNA synthetase multienzyme complex  cellular response to amino acid starvation  positive regulation of GTPase activity  cellular response to amino acid stimulus  cellular response to leucine  positive regulation of TORC1 signaling  cellular response to leucine starvation  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkLARS
Atlas of Cancer Signalling NetworkLARS
Wikipedia pathwaysLARS
Orthology - Evolution
OrthoDB51520
GeneTree (enSembl)ENSG00000133706
Phylogenetic Trees/Animal Genes : TreeFamLARS
HOVERGENQ9P2J5
HOGENOMQ9P2J5
Homologs : HomoloGeneLARS
Homology/Alignments : Family Browser (UCSC)LARS
Gene fusions - Rearrangements
Tumor Fusion PortalLARS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LARS
dbVarLARS
ClinVarLARS
1000_GenomesLARS 
Exome Variant ServerLARS
ExAC (Exome Aggregation Consortium)ENSG00000133706
GNOMAD BrowserENSG00000133706
Genetic variants : HAPMAP51520
Genomic Variants (DGV)LARS [DGVbeta]
DECIPHERLARS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLARS 
Mutations
ICGC Data PortalLARS 
TCGA Data PortalLARS 
Broad Tumor PortalLARS
OASIS PortalLARS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLARS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLARS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LARS
DgiDB (Drug Gene Interaction Database)LARS
DoCM (Curated mutations)LARS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LARS (select a term)
intoGenLARS
Cancer3DLARS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151350    615438   
Orphanet22479   
DisGeNETLARS
MedgenLARS
Genetic Testing Registry LARS
NextProtQ9P2J5 [Medical]
TSGene51520
GENETestsLARS
Target ValidationLARS
Huge Navigator LARS [HugePedia]
snp3D : Map Gene to Disease51520
BioCentury BCIQLARS
ClinGenLARS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51520
Chemical/Pharm GKB GenePA30297
Clinical trialLARS
Miscellaneous
canSAR (ICR)LARS (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLARS
EVEXLARS
GoPubMedLARS
iHOPLARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:19:34 CET 2017

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