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LARS2 (leucyl-tRNA synthetase 2, mitochondrial)

Identity

Alias_namesmitochondrial
Alias_symbol (synonym)KIAA0028
LEURS
MGC26121
mtLeuRS
Other aliasHLASA
PRLTS4
HGNC (Hugo) LARS2
LocusID (NCBI) 23395
Atlas_Id 50944
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 45388583 and ends at 45548836 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LARS2 (3p21.31) / RAB3GAP2 (1q41)LIMD1 (3p21.31) / LARS2 (3p21.31)LIMD1 3p21.31 / LARS2 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LARS2   17095
Cards
Entrez_Gene (NCBI)LARS2  23395  leucyl-tRNA synthetase 2, mitochondrial
AliasesHLASA; LEURS; PRLTS4; mtLeuRS
GeneCards (Weizmann)LARS2
Ensembl hg19 (Hinxton)ENSG00000011376 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011376 [Gene_View]  chr3:45388583-45548836 [Contig_View]  LARS2 [Vega]
ICGC DataPortalENSG00000011376
TCGA cBioPortalLARS2
AceView (NCBI)LARS2
Genatlas (Paris)LARS2
WikiGenes23395
SOURCE (Princeton)LARS2
Genetics Home Reference (NIH)LARS2
Genomic and cartography
GoldenPath hg38 (UCSC)LARS2  -     chr3:45388583-45548836 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LARS2  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblLARS2 - 3p21.31 [CytoView hg19]  LARS2 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBILARS2 [Mapview hg19]  LARS2 [Mapview hg38]
OMIM604544   615300   617021   
Gene and transcription
Genbank (Entrez)AK025465 AK026113 AK308146 BC025989 BI463427
RefSeq transcript (Entrez)NM_015340
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LARS2
Cluster EST : UnigeneHs.526975 [ NCBI ]
CGAP (NCI)Hs.526975
Alternative Splicing GalleryENSG00000011376
Gene ExpressionLARS2 [ NCBI-GEO ]   LARS2 [ EBI - ARRAY_EXPRESS ]   LARS2 [ SEEK ]   LARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)LARS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23395
GTEX Portal (Tissue expression)LARS2
Human Protein AtlasENSG00000011376-LARS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15031   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15031  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15031
Splice isoforms : SwissVarQ15031
Catalytic activity : Enzyme6.1.1.4 [ Enzyme-Expasy ]   6.1.1.46.1.1.4 [ IntEnz-EBI ]   6.1.1.4 [ BRENDA ]   6.1.1.4 [ KEGG ]   
PhosPhoSitePlusQ15031
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ia    Leu-tRNA-ligase    M/V/L/I-tRNA-synth_anticd-bd    Rossmann-like_a/b/a_fold    tRNAsynth_Ia_anticodon-bd    Val/Leu/Ile-tRNA-synth_edit   
Domain families : Pfam (Sanger)Anticodon_1 (PF08264)    tRNA-synt_1 (PF00133)   
Domain families : Pfam (NCBI)pfam08264    pfam00133   
Conserved Domain (NCBI)LARS2
DMDM Disease mutations23395
Blocks (Seattle)LARS2
SuperfamilyQ15031
Human Protein Atlas [tissue]ENSG00000011376-LARS2 [tissue]
Peptide AtlasQ15031
HPRD05178
IPIIPI00014213   IPI00926560   IPI00927574   IPI00924756   
Protein Interaction databases
DIP (DOE-UCLA)Q15031
IntAct (EBI)Q15031
FunCoupENSG00000011376
BioGRIDLARS2
STRING (EMBL)LARS2
ZODIACLARS2
Ontologies - Pathways
QuickGOQ15031
Ontology : AmiGOaminoacyl-tRNA editing activity  leucine-tRNA ligase activity  leucine-tRNA ligase activity  ATP binding  mitochondrion  mitochondrial matrix  tRNA aminoacylation for protein translation  leucyl-tRNA aminoacylation  regulation of translational fidelity  mitochondrial translation  
Ontology : EGO-EBIaminoacyl-tRNA editing activity  leucine-tRNA ligase activity  leucine-tRNA ligase activity  ATP binding  mitochondrion  mitochondrial matrix  tRNA aminoacylation for protein translation  leucyl-tRNA aminoacylation  regulation of translational fidelity  mitochondrial translation  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkLARS2
Atlas of Cancer Signalling NetworkLARS2
Wikipedia pathwaysLARS2
Orthology - Evolution
OrthoDB23395
GeneTree (enSembl)ENSG00000011376
Phylogenetic Trees/Animal Genes : TreeFamLARS2
HOVERGENQ15031
HOGENOMQ15031
Homologs : HomoloGeneLARS2
Homology/Alignments : Family Browser (UCSC)LARS2
Gene fusions - Rearrangements
Fusion : MitelmanLIMD1/LARS2 [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion: TCGA_MDACCLIMD1 3p21.31 LARS2 3p21.31 LUAD
Tumor Fusion PortalLARS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LARS2
dbVarLARS2
ClinVarLARS2
1000_GenomesLARS2 
Exome Variant ServerLARS2
ExAC (Exome Aggregation Consortium)ENSG00000011376
GNOMAD BrowserENSG00000011376
Genetic variants : HAPMAP23395
Genomic Variants (DGV)LARS2 [DGVbeta]
DECIPHERLARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLARS2 
Mutations
ICGC Data PortalLARS2 
TCGA Data PortalLARS2 
Broad Tumor PortalLARS2
OASIS PortalLARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLARS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LARS2
DgiDB (Drug Gene Interaction Database)LARS2
DoCM (Curated mutations)LARS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LARS2 (select a term)
intoGenLARS2
Cancer3DLARS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604544    615300    617021   
Orphanet2589   
DisGeNETLARS2
MedgenLARS2
Genetic Testing Registry LARS2
NextProtQ15031 [Medical]
TSGene23395
GENETestsLARS2
Target ValidationLARS2
Huge Navigator LARS2 [HugePedia]
snp3D : Map Gene to Disease23395
BioCentury BCIQLARS2
ClinGenLARS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23395
Chemical/Pharm GKB GenePA134982982
Clinical trialLARS2
Miscellaneous
canSAR (ICR)LARS2 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLARS2
EVEXLARS2
GoPubMedLARS2
iHOPLARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:19:34 CET 2017

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