LAS1L (LAS1 like ribosome biogenesis factor)

2016-10-01  

Identity

HGNC
LOCATION
Xq12
LOCUSID
ALIAS
Las1,Las1-like,WTS,dJ475B7.2
FUSION GENES

Other Information

Locus ID:

NCBI: 81887
MIM: 300964
HGNC: 25726
Ensembl: ENSG00000001497

Variants:

dbSNP: 81887
ClinVar: 81887
TCGA: ENSG00000001497
COSMIC: LAS1L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000001497ENST00000374804Q9Y4W2
ENSG00000001497ENST00000374807Q9Y4W2
ENSG00000001497ENST00000374811Q9Y4W2
ENSG00000001497ENST00000469091R4GNF7
ENSG00000001497ENST00000484069Q9Y4W2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
221907352012LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis.36
220839612012The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2.33
228728592012Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.26
206475402010Las1L is a nucleolar protein required for cell proliferation and ribosome biogenesis.25

Citation

Dessen P

LAS1L (LAS1 like ribosome biogenesis factor)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56577/las1l