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LAS1L (LAS1 like ribosome biogenesis factor)

Identity

Alias (NCBI)Las1
Las1-like
WTS
dJ475B7.2
HGNC (Hugo) LAS1L
HGNC Alias symbFLJ12525
Las1
HGNC Previous nameLAS1-like (S. cerevisiae)
LocusID (NCBI) 81887
Atlas_Id 56577
Location Xq12  [Link to chromosome band Xq12]
Location_base_pair Starts at 65512582 and ends at 65534787 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCA1 (9q31.1) / LAS1L (Xq12)LAS1L (Xq12) / SDC3 (1p35.2)MSS51 (10q22.2) / LAS1L (Xq12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LAS1L   25726
Cards
Entrez_Gene (NCBI)LAS1L    LAS1 like ribosome biogenesis factor
AliasesLas1; Las1-like; WTS; dJ475B7.2
GeneCards (Weizmann)LAS1L
Ensembl hg19 (Hinxton)ENSG00000001497 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000001497 [Gene_View]  ENSG00000001497 [Sequence]  chrX:65512582-65534787 [Contig_View]  LAS1L [Vega]
ICGC DataPortalENSG00000001497
TCGA cBioPortalLAS1L
AceView (NCBI)LAS1L
Genatlas (Paris)LAS1L
SOURCE (Princeton)LAS1L
Genetics Home Reference (NIH)LAS1L
Genomic and cartography
GoldenPath hg38 (UCSC)LAS1L  -     chrX:65512582-65534787 -  Xq12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAS1L  -     Xq12   [Description]    (hg19-Feb_2009)
GoldenPathLAS1L - Xq12 [CytoView hg19]  LAS1L - Xq12 [CytoView hg38]
ImmunoBaseENSG00000001497
Genome Data Viewer NCBILAS1L [Mapview hg19]  
OMIM300964   309585   
Gene and transcription
Genbank (Entrez)AF116730 AK022587 AK054695 AK054817 AK074087
RefSeq transcript (Entrez)NM_001170649 NM_001170650 NM_001375328 NM_001375329 NM_001375330 NM_001375331 NM_001375332 NM_001375333 NM_001375334 NM_001375335 NM_001375336 NM_001375337 NM_031206
Consensus coding sequences : CCDS (NCBI)LAS1L
Gene ExpressionLAS1L [ NCBI-GEO ]   LAS1L [ EBI - ARRAY_EXPRESS ]   LAS1L [ SEEK ]   LAS1L [ MEM ]
Gene Expression Viewer (FireBrowse)LAS1L [ Firebrowse - Broad ]
GenevisibleExpression of LAS1L in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81887
GTEX Portal (Tissue expression)LAS1L
Human Protein AtlasENSG00000001497-LAS1L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4W2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4W2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4W2
PhosPhoSitePlusQ9Y4W2
Domains : Interpro (EBI)Las1   
Domain families : Pfam (Sanger)Las1 (PF04031)   
Domain families : Pfam (NCBI)pfam04031   
Conserved Domain (NCBI)LAS1L
SuperfamilyQ9Y4W2
AlphaFold pdb e-kbQ9Y4W2   
Human Protein Atlas [tissue]ENSG00000001497-LAS1L [tissue]
HPRD06519
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4W2
IntAct (EBI)Q9Y4W2
BioGRIDLAS1L
STRING (EMBL)LAS1L
ZODIACLAS1L
Ontologies - Pathways
QuickGOQ9Y4W2
Ontology : AmiGOmaturation of 5.8S rRNA  maturation of LSU-rRNA  RNA binding  endonuclease activity  protein binding  nucleoplasm  nucleolus  rRNA processing  membrane  preribosome, large subunit precursor  MLL1 complex  nucleic acid phosphodiester bond hydrolysis  Las1 complex  
Ontology : EGO-EBImaturation of 5.8S rRNA  maturation of LSU-rRNA  RNA binding  endonuclease activity  protein binding  nucleoplasm  nucleolus  rRNA processing  membrane  preribosome, large subunit precursor  MLL1 complex  nucleic acid phosphodiester bond hydrolysis  Las1 complex  
NDEx NetworkLAS1L
Atlas of Cancer Signalling NetworkLAS1L
Wikipedia pathwaysLAS1L
Orthology - Evolution
OrthoDB81887
GeneTree (enSembl)ENSG00000001497
Phylogenetic Trees/Animal Genes : TreeFamLAS1L
Homologs : HomoloGeneLAS1L
Homology/Alignments : Family Browser (UCSC)LAS1L
Gene fusions - Rearrangements
Fusion : QuiverLAS1L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAS1L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAS1L
dbVarLAS1L
ClinVarLAS1L
MonarchLAS1L
1000_GenomesLAS1L 
Exome Variant ServerLAS1L
GNOMAD BrowserENSG00000001497
Varsome BrowserLAS1L
ACMGLAS1L variants
VarityQ9Y4W2
Genomic Variants (DGV)LAS1L [DGVbeta]
DECIPHERLAS1L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAS1L 
Mutations
ICGC Data PortalLAS1L 
TCGA Data PortalLAS1L 
Broad Tumor PortalLAS1L
OASIS PortalLAS1L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAS1L  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLAS1L
Mutations and Diseases : HGMDLAS1L
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLAS1L
DgiDB (Drug Gene Interaction Database)LAS1L
DoCM (Curated mutations)LAS1L
CIViC (Clinical Interpretations of Variants in Cancer)LAS1L
Cancer3DLAS1L
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300964    309585   
Orphanet3041    22935   
DisGeNETLAS1L
MedgenLAS1L
Genetic Testing Registry LAS1L
NextProtQ9Y4W2 [Medical]
GENETestsLAS1L
Target ValidationLAS1L
Huge Navigator LAS1L [HugePedia]
ClinGenLAS1L
Clinical trials, drugs, therapy
MyCancerGenomeLAS1L
Protein Interactions : CTDLAS1L
Pharm GKB GenePA128394732
PharosQ9Y4W2
Clinical trialLAS1L
Miscellaneous
canSAR (ICR)LAS1L
HarmonizomeLAS1L
DataMed IndexLAS1L
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLAS1L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:15:37 CEST 2021

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