Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

LAT (linker for activation of T-cells)

Identity

Alias_namestransmembrane adaptor
Alias_symbol (synonym)LAT1
Other aliaspp36
HGNC (Hugo) LAT
LocusID (NCBI) 27040
Atlas_Id 52202
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 28985066 and ends at 28990783 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LAT   18874
Cards
Entrez_Gene (NCBI)LAT  27040  linker for activation of T-cells
AliasesLAT1; pp36
GeneCards (Weizmann)LAT
Ensembl hg19 (Hinxton)ENSG00000213658 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213658 [Gene_View]  chr16:28985066-28990783 [Contig_View]  LAT [Vega]
ICGC DataPortalENSG00000213658
TCGA cBioPortalLAT
AceView (NCBI)LAT
Genatlas (Paris)LAT
WikiGenes27040
SOURCE (Princeton)LAT
Genetics Home Reference (NIH)LAT
Genomic and cartography
GoldenPath hg38 (UCSC)LAT  -     chr16:28985066-28990783 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAT  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblLAT - 16p11.2 [CytoView hg19]  LAT - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBILAT [Mapview hg19]  LAT [Mapview hg38]
OMIM602354   
Gene and transcription
Genbank (Entrez)AF036905 AF036906 AJ223280 AK093815 AK307342
RefSeq transcript (Entrez)NM_001014987 NM_001014988 NM_001014989 NM_014387
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LAT
Cluster EST : UnigeneHs.632179 [ NCBI ]
CGAP (NCI)Hs.632179
Alternative Splicing GalleryENSG00000213658
Gene ExpressionLAT [ NCBI-GEO ]   LAT [ EBI - ARRAY_EXPRESS ]   LAT [ SEEK ]   LAT [ MEM ]
Gene Expression Viewer (FireBrowse)LAT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27040
GTEX Portal (Tissue expression)LAT
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43561   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43561  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43561
Splice isoforms : SwissVarO43561
PhosPhoSitePlusO43561
Domains : Interpro (EBI)Linker_for_activat_Tcells_prot   
Domain families : Pfam (Sanger)LAT (PF15234)   
Domain families : Pfam (NCBI)pfam15234   
Conserved Domain (NCBI)LAT
DMDM Disease mutations27040
Blocks (Seattle)LAT
SuperfamilyO43561
Human Protein AtlasENSG00000213658
Peptide AtlasO43561
HPRD03832
IPIIPI00012888   IPI00218716   IPI01015021   IPI00930169   IPI00556022   
Protein Interaction databases
DIP (DOE-UCLA)O43561
IntAct (EBI)O43561
FunCoupENSG00000213658
BioGRIDLAT
STRING (EMBL)LAT
ZODIACLAT
Ontologies - Pathways
QuickGOO43561
Ontology : AmiGOMAPK cascade  immunological synapse  adaptive immune response  lymphocyte homeostasis  SH3/SH2 adaptor activity  Ras guanyl-nucleotide exchange factor activity  protein binding  plasma membrane  cell-cell junction  inflammatory response  immune response  integrin-mediated signaling pathway  Ras protein signal transduction  COP9 signalosome  positive regulation of signal transduction  gene expression  integral component of membrane  calcium-mediated signaling  protein kinase binding  platelet activation  intracellular signal transduction  Fc-epsilon receptor signaling pathway  T cell activation  mast cell granule  mast cell degranulation  positive regulation of GTPase activity  membrane raft  positive regulation of protein kinase activity  T cell receptor signaling pathway  regulation of T cell activation  
Ontology : EGO-EBIMAPK cascade  immunological synapse  adaptive immune response  lymphocyte homeostasis  SH3/SH2 adaptor activity  Ras guanyl-nucleotide exchange factor activity  protein binding  plasma membrane  cell-cell junction  inflammatory response  immune response  integrin-mediated signaling pathway  Ras protein signal transduction  COP9 signalosome  positive regulation of signal transduction  gene expression  integral component of membrane  calcium-mediated signaling  protein kinase binding  platelet activation  intracellular signal transduction  Fc-epsilon receptor signaling pathway  T cell activation  mast cell granule  mast cell degranulation  positive regulation of GTPase activity  membrane raft  positive regulation of protein kinase activity  T cell receptor signaling pathway  regulation of T cell activation  
Pathways : BIOCARTARas-Independent pathway in NK cell-mediated cytotoxicity [Genes]    T Cell Receptor Signaling Pathway [Genes]   
Pathways : KEGG   
NDEx NetworkLAT
Atlas of Cancer Signalling NetworkLAT
Wikipedia pathwaysLAT
Orthology - Evolution
OrthoDB27040
GeneTree (enSembl)ENSG00000213658
Phylogenetic Trees/Animal Genes : TreeFamLAT
HOVERGENO43561
HOGENOMO43561
Homologs : HomoloGeneLAT
Homology/Alignments : Family Browser (UCSC)LAT
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAT
dbVarLAT
ClinVarLAT
1000_GenomesLAT 
Exome Variant ServerLAT
ExAC (Exome Aggregation Consortium)LAT (select the gene name)
Genetic variants : HAPMAP27040
Genomic Variants (DGV)LAT [DGVbeta]
DECIPHERLAT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAT 
Mutations
ICGC Data PortalLAT 
TCGA Data PortalLAT 
Broad Tumor PortalLAT
OASIS PortalLAT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLAT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAT
DgiDB (Drug Gene Interaction Database)LAT
DoCM (Curated mutations)LAT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAT (select a term)
intoGenLAT
Cancer3DLAT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602354   
Orphanet
MedgenLAT
Genetic Testing Registry LAT
NextProtO43561 [Medical]
TSGene27040
GENETestsLAT
Target ValidationLAT
Huge Navigator LAT [HugePedia]
snp3D : Map Gene to Disease27040
BioCentury BCIQLAT
ClinGenLAT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27040
Chemical/Pharm GKB GenePA38728
Clinical trialLAT
Miscellaneous
canSAR (ICR)LAT (select the gene name)
Probes
Litterature
PubMed122 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAT
EVEXLAT
GoPubMedLAT
iHOPLAT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:40:16 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.