LATS2 (LATS, large tumor suppressor, homolog 2 (Drosophila))

Identity

Other names	FLJ13161
	KPM
HGNC	LATS2
Location	13q11-q12
Location_base_pair	Starts at 20445176 and ends at 20533722 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	LATS2   6515
Entrez_Gene	LATS2  26524  LATS, large tumor suppressor, homolog 2 (Drosophila)
	Cards
GeneCards	LATS2
Ensembl	LATS2 [Search_View]   ENSG00000150457 [Gene_View]
Genatlas	LATS2
GeneLynx	LATS2
eGenome	LATS2
euGene	26524
	Genomic and cartography
GoldenPath	LATS2  -     chr13:20445176-20533722 -  13q12.11   [Description]    (hg18-March_2006)
Ensembl	LATS2 - 13q12.11 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	LATS2
	Gene and transcription
Genbank	AB028019 [ ENTREZ ]
Genbank	AB209897 [ ENTREZ ]
Genbank	AF207547 [ ENTREZ ]
Genbank	AK123520 [ ENTREZ ]
Genbank	AK314235 [ ENTREZ ]
RefSeq	NM_014572 [ SRS ]    NM_014572 [ ENTREZ ]
RefSeq	AC_000056 [ SRS ]    AC_000056 [ ENTREZ ]
RefSeq	AC_000145 [ SRS ]    AC_000145 [ ENTREZ ]
RefSeq	NC_000013 [ SRS ]    NC_000013 [ ENTREZ ]
RefSeq	NT_024524 [ SRS ]    NT_024524 [ ENTREZ ]
RefSeq	NW_001838069 [ SRS ]    NW_001838069 [ ENTREZ ]
RefSeq	NW_925473 [ SRS ]    NW_925473 [ ENTREZ ]
AceView	LATS2 AceView - NCBI
Unigene	Hs.78960 [ SRS ]    Hs.78960 [ NCBI ]     HS78960 [ spliceNest ]
Fast-db	486 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q59EB4 [ SRS]    Q59EB4 [ EXPASY ]     Q59EB4 [ INTERPRO ]     Q59EB4 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Prosite	PS50030 UBA [ SRS ]    PS50030 UBA [ Expasy ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR000449 UBA/transl_elong_EF1B_N [ SRS ]    IPR000449 UBA/transl_elong_EF1B_N [ EBI ]
Interpro	IPR015940 UBA/transl_elong_EF1B_N_euk [ SRS ]    IPR015940 UBA/transl_elong_EF1B_N_euk [ EBI ]
CluSTr	Q59EB4
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Pfam	PF00627 UBA [ SRS ]    PF00627 UBA [ Sanger ]    pfam00627 [ NCBI-CDD ]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q59EB4 Q59EB4_HUMAN [ Domain structure ]   Q59EB4 Q59EB4_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q59EB4
HPRD	07277
	Protein Interaction databases
DIP	Q59EB4
IntAct	Q59EB4
	Polymorphism : SNP, mutations, diseases
OMIM	604861    [ map ]
GENECLINICS	604861
SNP	LATS2 [dbSNP-NCBI]
SNP	NM_014572 [SNP-NCI]
SNP	LATS2 [GeneSNPs - Utah]  LATS2] [HGBASE - SRS]
HAPMAP	LATS2 [HAPMAP]
COSMIC	LATS2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	LATS2
	General knowledge
Family Browser	LATS2 [UCSC Family Browser]
SOURCE	NM_014572
SMD	Hs.78960
SAGE	Hs.78960
GO	G1/S transition of mitotic cell cycle [Amigo]  G1/S transition of mitotic cell cycle
GO	nucleotide binding [Amigo]  nucleotide binding
GO	magnesium ion binding [Amigo]  magnesium ion binding
GO	spindle pole [Amigo]  spindle pole
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	ATP binding [Amigo]  ATP binding
GO	ATP binding [Amigo]  ATP binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	centrosome [Amigo]  centrosome
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	mitosis [Amigo]  mitosis
GO	protein kinase cascade [Amigo]  protein kinase cascade
GO	hormone-mediated signaling [Amigo]  hormone-mediated signaling
GO	transferase activity [Amigo]  transferase activity
GO	negative regulation of cyclin-dependent protein kinase activity [Amigo]  negative regulation of cyclin-dependent protein kinase activity
GO	cell division [Amigo]  cell division
PubGene	LATS2
TreeFam	LATS2
CTD	26524 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	LATS2 Related clones (RZPD - Berlin)
	PubMed
PubMed	14 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:48:18 2008