Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

LAX1 (lymphocyte transmembrane adaptor 1)

Identity

Alias (NCBI)LAX
HGNC (Hugo) LAX1
HGNC Alias symbLAX
FLJ20340
HGNC Alias nameLAT-like membrane associated protein
 linker for activation of x cells
LocusID (NCBI) 54900
Atlas_Id 65180
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 203765183 and ends at 203776352 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LAX1   26005
Cards
Entrez_Gene (NCBI)LAX1    lymphocyte transmembrane adaptor 1
AliasesLAX
GeneCards (Weizmann)LAX1
Ensembl hg19 (Hinxton)ENSG00000122188 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122188 [Gene_View]  ENSG00000122188 [Sequence]  chr1:203765183-203776352 [Contig_View]  LAX1 [Vega]
ICGC DataPortalENSG00000122188
TCGA cBioPortalLAX1
AceView (NCBI)LAX1
Genatlas (Paris)LAX1
SOURCE (Princeton)LAX1
Genetics Home Reference (NIH)LAX1
Genomic and cartography
GoldenPath hg38 (UCSC)LAX1  -     chr1:203765183-203776352 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAX1  -     1q32.1   [Description]    (hg19-Feb_2009)
GoldenPathLAX1 - 1q32.1 [CytoView hg19]  LAX1 - 1q32.1 [CytoView hg38]
ImmunoBaseENSG00000122188
Genome Data Viewer NCBILAX1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK000347 AK225331 AK301076 AK301421 AY090784
RefSeq transcript (Entrez)NM_001136190 NM_001282878 NM_017773
Consensus coding sequences : CCDS (NCBI)LAX1
Gene ExpressionLAX1 [ NCBI-GEO ]   LAX1 [ EBI - ARRAY_EXPRESS ]   LAX1 [ SEEK ]   LAX1 [ MEM ]
Gene Expression Viewer (FireBrowse)LAX1 [ Firebrowse - Broad ]
GenevisibleExpression of LAX1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54900
GTEX Portal (Tissue expression)LAX1
Human Protein AtlasENSG00000122188-LAX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWV1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWV1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWV1
PhosPhoSitePlusQ8IWV1
Domains : Interpro (EBI)LAX   
Domain families : Pfam (Sanger)LAX (PF15681)   
Domain families : Pfam (NCBI)pfam15681   
Conserved Domain (NCBI)LAX1
SuperfamilyQ8IWV1
AlphaFold pdb e-kbQ8IWV1   
Human Protein Atlas [tissue]ENSG00000122188-LAX1 [tissue]
HPRD08312
Protein Interaction databases
DIP (DOE-UCLA)Q8IWV1
IntAct (EBI)Q8IWV1
BioGRIDLAX1
STRING (EMBL)LAX1
ZODIACLAX1
Ontologies - Pathways
QuickGOQ8IWV1
Ontology : AmiGOinactivation of MAPK activity  adaptive immune response  protein binding  Golgi apparatus  cytosol  plasma membrane  plasma membrane  immune response  immune response  membrane  integral component of membrane  protein kinase binding  intracellular signal transduction  intracellular signal transduction  B cell activation  SH2 domain binding  membrane raft  lymphocyte activation  antigen receptor-mediated signaling pathway  negative regulation of T cell activation  negative regulation of T cell activation  
Ontology : EGO-EBIinactivation of MAPK activity  adaptive immune response  protein binding  Golgi apparatus  cytosol  plasma membrane  plasma membrane  immune response  immune response  membrane  integral component of membrane  protein kinase binding  intracellular signal transduction  intracellular signal transduction  B cell activation  SH2 domain binding  membrane raft  lymphocyte activation  antigen receptor-mediated signaling pathway  negative regulation of T cell activation  negative regulation of T cell activation  
NDEx NetworkLAX1
Atlas of Cancer Signalling NetworkLAX1
Wikipedia pathwaysLAX1
Orthology - Evolution
OrthoDB54900
GeneTree (enSembl)ENSG00000122188
Phylogenetic Trees/Animal Genes : TreeFamLAX1
Homologs : HomoloGeneLAX1
Homology/Alignments : Family Browser (UCSC)LAX1
Gene fusions - Rearrangements
Fusion : QuiverLAX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAX1
dbVarLAX1
ClinVarLAX1
MonarchLAX1
1000_GenomesLAX1 
Exome Variant ServerLAX1
GNOMAD BrowserENSG00000122188
Varsome BrowserLAX1
ACMGLAX1 variants
VarityQ8IWV1
Genomic Variants (DGV)LAX1 [DGVbeta]
DECIPHERLAX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAX1 
Mutations
ICGC Data PortalLAX1 
TCGA Data PortalLAX1 
Broad Tumor PortalLAX1
OASIS PortalLAX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAX1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLAX1
Mutations and Diseases : HGMDLAX1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLAX1
DgiDB (Drug Gene Interaction Database)LAX1
DoCM (Curated mutations)LAX1
CIViC (Clinical Interpretations of Variants in Cancer)LAX1
Cancer3DLAX1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETLAX1
MedgenLAX1
Genetic Testing Registry LAX1
NextProtQ8IWV1 [Medical]
GENETestsLAX1
Target ValidationLAX1
Huge Navigator LAX1 [HugePedia]
ClinGenLAX1
Clinical trials, drugs, therapy
MyCancerGenomeLAX1
Protein Interactions : CTDLAX1
Pharm GKB GenePA142671569
PharosQ8IWV1
Clinical trialLAX1
Miscellaneous
canSAR (ICR)LAX1
HarmonizomeLAX1
ARCHS4LAX1
DataMed IndexLAX1
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLAX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Jan 16 18:58:19 CET 2022

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.