LBP (lipopolysaccharide binding protein)

2008-10-01  

Identity

HGNC
LOCATION
20q11.23
LOCUSID
ALIAS
BPIFD2

Other Information

Locus ID:

NCBI: 3929
MIM: 151990
HGNC: 6517
Ensembl: ENSG00000129988

Variants:

dbSNP: 3929
ClinVar: 3929
TCGA: ENSG00000129988
COSMIC: LBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129988ENST00000217407P18428

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Transfer of LPS from LBP carrier to CD14REACTOMER-HSA-166020
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Regulation of TLR by endogenous ligandREACTOMER-HSA-5686938
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125942072003Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.173
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
205307472010A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese.85
185593432008Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition.74
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
93387871997Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection.53
233499362013Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity.48
125387002003Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons.45
113734192001Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis.41
217403122011Soluble CD14 subtype presepsin (sCD14-ST) and lipopolysaccharide binding protein (LBP) in neonatal sepsis: new clinical and analytical perspectives for two old biomarkers.33

Citation

Dessen P

LBP (lipopolysaccharide binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50443/lbp