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LBP (lipopolysaccharide binding protein)

Identity

Alias_namesmember 2
Alias_symbol (synonym)BPIFD2
Other alias
HGNC (Hugo) LBP
LocusID (NCBI) 3929
Atlas_Id 50443
Location 20q11.23  [Link to chromosome band 20q11]
Location_base_pair Starts at 38346411 and ends at 38377011 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LBP   6517
Cards
Entrez_Gene (NCBI)LBP  3929  lipopolysaccharide binding protein
AliasesBPIFD2
GeneCards (Weizmann)LBP
Ensembl hg19 (Hinxton)ENSG00000129988 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129988 [Gene_View]  chr20:38346411-38377011 [Contig_View]  LBP [Vega]
ICGC DataPortalENSG00000129988
TCGA cBioPortalLBP
AceView (NCBI)LBP
Genatlas (Paris)LBP
WikiGenes3929
SOURCE (Princeton)LBP
Genetics Home Reference (NIH)LBP
Genomic and cartography
GoldenPath hg38 (UCSC)LBP  -     chr20:38346411-38377011 +  20q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LBP  -     20q11.23   [Description]    (hg19-Feb_2009)
EnsemblLBP - 20q11.23 [CytoView hg19]  LBP - 20q11.23 [CytoView hg38]
Mapping of homologs : NCBILBP [Mapview hg19]  LBP [Mapview hg38]
OMIM151990   
Gene and transcription
Genbank (Entrez)AF105067 AK313625 AY344471 BC022256 BQ028088
RefSeq transcript (Entrez)NM_004139
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LBP
Cluster EST : UnigeneHs.154078 [ NCBI ]
CGAP (NCI)Hs.154078
Alternative Splicing GalleryENSG00000129988
Gene ExpressionLBP [ NCBI-GEO ]   LBP [ EBI - ARRAY_EXPRESS ]   LBP [ SEEK ]   LBP [ MEM ]
Gene Expression Viewer (FireBrowse)LBP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3929
GTEX Portal (Tissue expression)LBP
Human Protein AtlasENSG00000129988-LBP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18428   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18428  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18428
Splice isoforms : SwissVarP18428
PhosPhoSitePlusP18428
Domaine pattern : Prosite (Expaxy)LBP_BPI_CETP (PS00400)   
Domains : Interpro (EBI)Bactericidal_perm-incr_a/b_dom    BPI/LBP    BPI/LBP/Plunc    LBP    Lipid-bd_serum_glycop_C    Lipid-bd_serum_glycop_CS    Lipid-bd_serum_glycop_N   
Domain families : Pfam (Sanger)LBP_BPI_CETP (PF01273)    LBP_BPI_CETP_C (PF02886)   
Domain families : Pfam (NCBI)pfam01273    pfam02886   
Domain families : Smart (EMBL)BPI1 (SM00328)  BPI2 (SM00329)  
Conserved Domain (NCBI)LBP
DMDM Disease mutations3929
Blocks (Seattle)LBP
SuperfamilyP18428
Human Protein Atlas [tissue]ENSG00000129988-LBP [tissue]
Peptide AtlasP18428
HPRD07175
IPIIPI00032311   IPI01009486   
Protein Interaction databases
DIP (DOE-UCLA)P18428
IntAct (EBI)P18428
FunCoupENSG00000129988
BioGRIDLBP
STRING (EMBL)LBP
ZODIACLBP
Ontologies - Pathways
QuickGOP18428
Ontology : AmiGOlipopolysaccharide binding  lipopolysaccharide binding  lipopolysaccharide binding  toll-like receptor signaling pathway  leukocyte chemotaxis involved in inflammatory response  macrophage activation involved in immune response  macrophage activation involved in immune response  receptor binding  protein binding  extracellular region  extracellular space  extracellular space  acute-phase response  acute-phase response  cellular defense response  opsonization  opsonization  cell surface  lipopolysaccharide transport  membrane  lipopolysaccharide-mediated signaling pathway  detection of molecule of bacterial origin  response to lipopolysaccharide  negative regulation of tumor necrosis factor production  positive regulation of chemokine production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of tumor necrosis factor production  positive regulation of tumor necrosis factor production  macromolecule localization  toll-like receptor 4 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  positive regulation of tumor necrosis factor biosynthetic process  positive regulation of macrophage activation  negative regulation of growth of symbiont in host  innate immune response  innate immune response  positive regulation of cytolysis  defense response to Gram-negative bacterium  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  positive regulation of respiratory burst involved in inflammatory response  extracellular exosome  lipoteichoic acid binding  cellular response to lipopolysaccharide  cellular response to lipopolysaccharide  cellular response to lipoteichoic acid  lipopeptide binding  positive regulation of neutrophil chemotaxis  
Ontology : EGO-EBIlipopolysaccharide binding  lipopolysaccharide binding  lipopolysaccharide binding  toll-like receptor signaling pathway  leukocyte chemotaxis involved in inflammatory response  macrophage activation involved in immune response  macrophage activation involved in immune response  receptor binding  protein binding  extracellular region  extracellular space  extracellular space  acute-phase response  acute-phase response  cellular defense response  opsonization  opsonization  cell surface  lipopolysaccharide transport  membrane  lipopolysaccharide-mediated signaling pathway  detection of molecule of bacterial origin  response to lipopolysaccharide  negative regulation of tumor necrosis factor production  positive regulation of chemokine production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of tumor necrosis factor production  positive regulation of tumor necrosis factor production  macromolecule localization  toll-like receptor 4 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  positive regulation of tumor necrosis factor biosynthetic process  positive regulation of macrophage activation  negative regulation of growth of symbiont in host  innate immune response  innate immune response  positive regulation of cytolysis  defense response to Gram-negative bacterium  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  positive regulation of respiratory burst involved in inflammatory response  extracellular exosome  lipoteichoic acid binding  cellular response to lipopolysaccharide  cellular response to lipopolysaccharide  cellular response to lipoteichoic acid  lipopeptide binding  positive regulation of neutrophil chemotaxis  
Pathways : BIOCARTAInactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages [Genes]   
Pathways : KEGGNF-kappa B signaling pathway    Toll-like receptor signaling pathway    Salmonella infection    Tuberculosis   
NDEx NetworkLBP
Atlas of Cancer Signalling NetworkLBP
Wikipedia pathwaysLBP
Orthology - Evolution
OrthoDB3929
GeneTree (enSembl)ENSG00000129988
Phylogenetic Trees/Animal Genes : TreeFamLBP
HOVERGENP18428
HOGENOMP18428
Homologs : HomoloGeneLBP
Homology/Alignments : Family Browser (UCSC)LBP
Gene fusions - Rearrangements
Tumor Fusion PortalLBP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLBP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LBP
dbVarLBP
ClinVarLBP
1000_GenomesLBP 
Exome Variant ServerLBP
ExAC (Exome Aggregation Consortium)ENSG00000129988
GNOMAD BrowserENSG00000129988
Genetic variants : HAPMAP3929
Genomic Variants (DGV)LBP [DGVbeta]
DECIPHERLBP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLBP 
Mutations
ICGC Data PortalLBP 
TCGA Data PortalLBP 
Broad Tumor PortalLBP
OASIS PortalLBP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLBP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLBP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LBP
DgiDB (Drug Gene Interaction Database)LBP
DoCM (Curated mutations)LBP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LBP (select a term)
intoGenLBP
Cancer3DLBP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151990   
Orphanet
DisGeNETLBP
MedgenLBP
Genetic Testing Registry LBP
NextProtP18428 [Medical]
TSGene3929
GENETestsLBP
Target ValidationLBP
Huge Navigator LBP [HugePedia]
snp3D : Map Gene to Disease3929
BioCentury BCIQLBP
ClinGenLBP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3929
Chemical/Pharm GKB GenePA30303
Clinical trialLBP
Miscellaneous
canSAR (ICR)LBP (select the gene name)
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLBP
EVEXLBP
GoPubMedLBP
iHOPLBP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:19:35 CET 2017

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