Atlas of Genetics and Cytogenetics in Oncology and Haematology

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LBX1 (ladybird homeobox 1)

Identity

Alias_namesladybird homeobox homolog 1 (Drosophila)
Alias_symbol (synonym)LBX1H
HPX6
Other aliasHPX-6
homeobox
HGNC (Hugo) LBX1
LocusID (NCBI) 10660
Atlas_Id 51096
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 101226976 and ends at 101228960 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;9)(q21;p13) PAX5/DACH2

External links

Nomenclature
HGNC (Hugo)LBX1   16960
Cards
Entrez_Gene (NCBI)LBX1  10660  ladybird homeobox 1
AliasesHPX-6; HPX6; LBX1H; homeobox
GeneCards (Weizmann)LBX1
Ensembl hg19 (Hinxton)ENSG00000138136 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138136 [Gene_View]  chr10:101226976-101228960 [Contig_View]  LBX1 [Vega]
ICGC DataPortalENSG00000138136
TCGA cBioPortalLBX1
AceView (NCBI)LBX1
Genatlas (Paris)LBX1
WikiGenes10660
SOURCE (Princeton)LBX1
Genetics Home Reference (NIH)LBX1
Genomic and cartography
GoldenPath hg38 (UCSC)LBX1  -     chr10:101226976-101228960 -  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LBX1  -     10q24.32   [Description]    (hg19-Feb_2009)
EnsemblLBX1 - 10q24.32 [CytoView hg19]  LBX1 - 10q24.32 [CytoView hg38]
Mapping of homologs : NCBILBX1 [Mapview hg19]  LBX1 [Mapview hg38]
OMIM604255   
Gene and transcription
Genbank (Entrez)AJ004949 BC069156 BC136321 X74863 X90828
RefSeq transcript (Entrez)NM_006562
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LBX1
Cluster EST : UnigeneHs.37128 [ NCBI ]
CGAP (NCI)Hs.37128
Alternative Splicing GalleryENSG00000138136
Gene ExpressionLBX1 [ NCBI-GEO ]   LBX1 [ EBI - ARRAY_EXPRESS ]   LBX1 [ SEEK ]   LBX1 [ MEM ]
Gene Expression Viewer (FireBrowse)LBX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10660
GTEX Portal (Tissue expression)LBX1
Human Protein AtlasENSG00000138136-LBX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52954   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52954  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52954
Splice isoforms : SwissVarP52954
PhosPhoSitePlusP52954
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    HTH_motif   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)LBX1
DMDM Disease mutations10660
Blocks (Seattle)LBX1
SuperfamilyP52954
Human Protein Atlas [tissue]ENSG00000138136-LBX1 [tissue]
Peptide AtlasP52954
HPRD09178
IPIIPI00006058   
Protein Interaction databases
DIP (DOE-UCLA)P52954
IntAct (EBI)P52954
FunCoupENSG00000138136
BioGRIDLBX1
STRING (EMBL)LBX1
ZODIACLBX1
Ontologies - Pathways
QuickGOP52954
Ontology : AmiGOheart looping  DNA binding transcription factor activity  nucleus  transcription factor complex  transcription, DNA-templated  muscle organ development  negative regulation of cell proliferation  anatomical structure morphogenesis  spinal cord motor neuron differentiation  regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification  sequence-specific DNA binding  negative regulation of neuron differentiation  neuron fate determination  
Ontology : EGO-EBIheart looping  DNA binding transcription factor activity  nucleus  transcription factor complex  transcription, DNA-templated  muscle organ development  negative regulation of cell proliferation  anatomical structure morphogenesis  spinal cord motor neuron differentiation  regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification  sequence-specific DNA binding  negative regulation of neuron differentiation  neuron fate determination  
NDEx NetworkLBX1
Atlas of Cancer Signalling NetworkLBX1
Wikipedia pathwaysLBX1
Orthology - Evolution
OrthoDB10660
GeneTree (enSembl)ENSG00000138136
Phylogenetic Trees/Animal Genes : TreeFamLBX1
HOVERGENP52954
HOGENOMP52954
Homologs : HomoloGeneLBX1
Homology/Alignments : Family Browser (UCSC)LBX1
Gene fusions - Rearrangements
Fusion : QuiverLBX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLBX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LBX1
dbVarLBX1
ClinVarLBX1
1000_GenomesLBX1 
Exome Variant ServerLBX1
ExAC (Exome Aggregation Consortium)ENSG00000138136
GNOMAD BrowserENSG00000138136
Genetic variants : HAPMAP10660
Genomic Variants (DGV)LBX1 [DGVbeta]
DECIPHERLBX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLBX1 
Mutations
ICGC Data PortalLBX1 
TCGA Data PortalLBX1 
Broad Tumor PortalLBX1
OASIS PortalLBX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLBX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLBX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LBX1
DgiDB (Drug Gene Interaction Database)LBX1
DoCM (Curated mutations)LBX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LBX1 (select a term)
intoGenLBX1
Cancer3DLBX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604255   
Orphanet
DisGeNETLBX1
MedgenLBX1
Genetic Testing Registry LBX1
NextProtP52954 [Medical]
TSGene10660
GENETestsLBX1
Target ValidationLBX1
Huge Navigator LBX1 [HugePedia]
snp3D : Map Gene to Disease10660
BioCentury BCIQLBX1
ClinGenLBX1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10660
Chemical/Pharm GKB GenePA142671561
Clinical trialLBX1
Miscellaneous
canSAR (ICR)LBX1 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLBX1
EVEXLBX1
GoPubMedLBX1
iHOPLBX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jun 18 19:27:53 CEST 2018
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