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LBX1 (ladybird homeobox 1)

Identity

Alias (NCBI)HPX-6
HPX6
LBX1H
homeobox
HGNC (Hugo) LBX1
HGNC Alias symbLBX1H
HPX6
HGNC Previous nameladybird homeobox homolog 1 (Drosophila)
LocusID (NCBI) 10660
Atlas_Id 51096
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 101226976 and ends at 101228960 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;9)(q21;p13) PAX5/DACH2


External links

 

Nomenclature
HGNC (Hugo)LBX1   16960
Cards
Entrez_Gene (NCBI)LBX1    ladybird homeobox 1
AliasesHPX-6; HPX6; LBX1H; homeobox
GeneCards (Weizmann)LBX1
Ensembl hg19 (Hinxton)ENSG00000138136 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138136 [Gene_View]  ENSG00000138136 [Sequence]  chr10:101226976-101228960 [Contig_View]  LBX1 [Vega]
ICGC DataPortalENSG00000138136
TCGA cBioPortalLBX1
AceView (NCBI)LBX1
Genatlas (Paris)LBX1
SOURCE (Princeton)LBX1
Genetics Home Reference (NIH)LBX1
Genomic and cartography
GoldenPath hg38 (UCSC)LBX1  -     chr10:101226976-101228960 -  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LBX1  -     10q24.32   [Description]    (hg19-Feb_2009)
GoldenPathLBX1 - 10q24.32 [CytoView hg19]  LBX1 - 10q24.32 [CytoView hg38]
ImmunoBaseENSG00000138136
Genome Data Viewer NCBILBX1 [Mapview hg19]  
OMIM604255   
Gene and transcription
Genbank (Entrez)AJ004949 BC069156 BC136321 X74863 X90828
RefSeq transcript (Entrez)NM_006562
Consensus coding sequences : CCDS (NCBI)LBX1
Gene ExpressionLBX1 [ NCBI-GEO ]   LBX1 [ EBI - ARRAY_EXPRESS ]   LBX1 [ SEEK ]   LBX1 [ MEM ]
Gene Expression Viewer (FireBrowse)LBX1 [ Firebrowse - Broad ]
GenevisibleExpression of LBX1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10660
GTEX Portal (Tissue expression)LBX1
Human Protein AtlasENSG00000138136-LBX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52954   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52954  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52954
PhosPhoSitePlusP52954
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    HTH_motif   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)LBX1
SuperfamilyP52954
AlphaFold pdb e-kbP52954   
Human Protein Atlas [tissue]ENSG00000138136-LBX1 [tissue]
HPRD09178
Protein Interaction databases
DIP (DOE-UCLA)P52954
IntAct (EBI)P52954
BioGRIDLBX1
STRING (EMBL)LBX1
ZODIACLBX1
Ontologies - Pathways
QuickGOP52954
Ontology : AmiGOchromatin  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  heart looping  protein binding  nucleus  transcription regulator complex  regulation of transcription by RNA polymerase II  muscle organ development  negative regulation of cell population proliferation  anatomical structure morphogenesis  spinal cord motor neuron differentiation  negative regulation of neuron differentiation  neuron fate determination  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  heart looping  protein binding  nucleus  transcription regulator complex  regulation of transcription by RNA polymerase II  muscle organ development  negative regulation of cell population proliferation  anatomical structure morphogenesis  spinal cord motor neuron differentiation  negative regulation of neuron differentiation  neuron fate determination  sequence-specific double-stranded DNA binding  
NDEx NetworkLBX1
Atlas of Cancer Signalling NetworkLBX1
Wikipedia pathwaysLBX1
Orthology - Evolution
OrthoDB10660
GeneTree (enSembl)ENSG00000138136
Phylogenetic Trees/Animal Genes : TreeFamLBX1
Homologs : HomoloGeneLBX1
Homology/Alignments : Family Browser (UCSC)LBX1
Gene fusions - Rearrangements
Fusion : QuiverLBX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLBX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LBX1
dbVarLBX1
ClinVarLBX1
MonarchLBX1
1000_GenomesLBX1 
Exome Variant ServerLBX1
GNOMAD BrowserENSG00000138136
Varsome BrowserLBX1
ACMGLBX1 variants
VarityP52954
Genomic Variants (DGV)LBX1 [DGVbeta]
DECIPHERLBX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLBX1 
Mutations
ICGC Data PortalLBX1 
TCGA Data PortalLBX1 
Broad Tumor PortalLBX1
OASIS PortalLBX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLBX1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLBX1
Mutations and Diseases : HGMDLBX1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLBX1
DgiDB (Drug Gene Interaction Database)LBX1
DoCM (Curated mutations)LBX1
CIViC (Clinical Interpretations of Variants in Cancer)LBX1
Cancer3DLBX1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604255   
Orphanet
DisGeNETLBX1
MedgenLBX1
Genetic Testing Registry LBX1
NextProtP52954 [Medical]
GENETestsLBX1
Target ValidationLBX1
Huge Navigator LBX1 [HugePedia]
ClinGenLBX1 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeLBX1
Protein Interactions : CTDLBX1
Pharm GKB GenePA142671561
PharosP52954
Clinical trialLBX1
Miscellaneous
canSAR (ICR)LBX1
HarmonizomeLBX1
DataMed IndexLBX1
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLBX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:15:39 CEST 2021

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