Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

LCAT (lecithin-cholesterol acyltransferase)

Identity

Other names-
HGNC (Hugo) LCAT
LocusID (NCBI) 3931
Location 16q22.1
Location_base_pair Starts at 67973787 and ends at 67978015 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LCAT   6522
Cards
Entrez_Gene (NCBI)LCAT  3931  lecithin-cholesterol acyltransferase
GeneCards (Weizmann)LCAT
Ensembl (Hinxton)ENSG00000213398 [Gene_View]  chr16:67973787-67978015 [Contig_View]  LCAT [Vega]
ICGC DataPortalENSG00000213398
cBioPortalLCAT
AceView (NCBI)LCAT
Genatlas (Paris)LCAT
WikiGenes3931
SOURCE (Princeton)NM_000229
Genomic and cartography
GoldenPath (UCSC)LCAT  -  16q22.1   chr16:67973787-67978015 -  16q22.1   [Description]    (hg19-Feb_2009)
EnsemblLCAT - 16q22.1 [CytoView]
Mapping of homologs : NCBILCAT [Mapview]
OMIM136120   245900   606967   
Gene and transcription
Genbank (Entrez)BC014781 BT009748 M12625 M26268 X06537
RefSeq transcript (Entrez)NM_000229
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_009778 NT_010498 NW_001838290 NW_004929402
Consensus coding sequences : CCDS (NCBI)LCAT
Cluster EST : UnigeneHs.387239 [ NCBI ]
CGAP (NCI)Hs.387239
Alternative Splicing : Fast-db (Paris)GSHG0033255
Alternative Splicing GalleryENSG00000213398
Gene ExpressionLCAT [ NCBI-GEO ]     LCAT [ SEEK ]   LCAT [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04180 (Uniprot)
NextProtP04180  [Medical]
With graphics : InterProP04180
Splice isoforms : SwissVarP04180 (Swissvar)
Catalytic activity : Enzyme2.3.1.43 [ Enzyme-Expasy ]   2.3.1.432.3.1.43 [ IntEnz-EBI ]   2.3.1.43 [ BRENDA ]   2.3.1.43 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)LIPASE_SER (PS00120)   
Domains : Interpro (EBI)AB_hydrolase [organisation]   LACT/PDAT_acylTrfase [organisation]  
Related proteins : CluSTrP04180
Domain families : Pfam (Sanger)LCAT (PF02450)   
Domain families : Pfam (NCBI)pfam02450   
DMDM Disease mutations3931
Blocks (Seattle)P04180
Human Protein AtlasENSG00000213398 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP04180
HPRD06098
IPIIPI00022331   
Protein Interaction databases
DIP (DOE-UCLA)P04180
IntAct (EBI)P04180
FunCoupENSG00000213398
BioGRIDLCAT
InParanoidP04180
Interologous Interaction database P04180
IntegromeDBLCAT
STRING (EMBL)LCAT
Ontologies - Pathways
Ontology : AmiGOphosphatidylcholine-sterol O-acyltransferase activity  phosphatidylcholine-sterol O-acyltransferase activity  protein binding  extracellular region  extracellular space  phospholipid metabolic process  phosphatidylcholine biosynthetic process  cholesterol metabolic process  cholesterol transport  apolipoprotein A-I binding  high-density lipoprotein particle  very-low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  cholesterol esterification  lipoprotein metabolic process  lipoprotein biosynthetic process  cholesterol homeostasis  reverse cholesterol transport  small molecule metabolic process  extracellular vesicular exosome  regulation of high-density lipoprotein particle assembly  
Ontology : EGO-EBIphosphatidylcholine-sterol O-acyltransferase activity  phosphatidylcholine-sterol O-acyltransferase activity  protein binding  extracellular region  extracellular space  phospholipid metabolic process  phosphatidylcholine biosynthetic process  cholesterol metabolic process  cholesterol transport  apolipoprotein A-I binding  high-density lipoprotein particle  very-low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  cholesterol esterification  lipoprotein metabolic process  lipoprotein biosynthetic process  cholesterol homeostasis  reverse cholesterol transport  small molecule metabolic process  extracellular vesicular exosome  regulation of high-density lipoprotein particle assembly  
Pathways : KEGGGlycerophospholipid metabolism   
Protein Interaction DatabaseLCAT
Wikipedia pathwaysLCAT
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)LCAT
snp3D : Map Gene to Disease3931
SNP (GeneSNP Utah)LCAT
SNP : HGBaseLCAT
Genetic variants : HAPMAPLCAT
Exome VariantLCAT
1000_GenomesLCAT 
ICGC programENSG00000213398 
Somatic Mutations in Cancer : COSMICLCAT 
CONAN: Copy Number AnalysisLCAT 
Mutations and Diseases : HGMDLCAT
Genomic VariantsLCAT  LCAT [DGVbeta]
dbVarLCAT
ClinVarLCAT
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM136120    245900    606967   
MedgenLCAT
GENETestsLCAT
Disease Genetic AssociationLCAT
Huge Navigator LCAT [HugePedia]  LCAT [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneLCAT
Homology/Alignments : Family Browser (UCSC)LCAT
Phylogenetic Trees/Animal Genes : TreeFamLCAT
Chemical/Protein Interactions : CTD3931
Chemical/Pharm GKB GenePA226
Clinical trialLCAT
Cancer Resource (Charite)ENSG00000213398
Other databases
Probes
Litterature
PubMed143 Pubmed reference(s) in Entrez
CoreMineLCAT
iHOPLCAT
OncoSearchLCAT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:01:55 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.