LCE3C (late cornified envelope 3C)

2014-11-01 Affiliation

Identity

HGNC

LCE3C

LOCATION

1q21.3

LOCUSID

353144

ALIAS

LEP15,SPRL3A

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 353144
MIM: 612615
HGNC: 16612
Ensembl: ENSG00000244057

Variants:

dbSNP: 353144
ClinVar: 353144
TCGA: ENSG00000244057
COSMIC: LCE3C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000244057	ENST00000333881	Q5T5A8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Developmental Biology	REACTOME	R-HSA-1266738
Keratinization	REACTOME	R-HSA-6805567
Formation of the cornified envelope	REACTOME	R-HSA-6809371

References

Pubmed ID	Year	Title	Citations
19169253	2009	Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.	170
19169253	2009	Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.	170
15854049	2005	Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.	56
21107349	2011	Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.	31
20016497	2010	Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors.	23
20016497	2010	Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors.	23
22512642	2012	Paediatric-onset psoriasis is associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C*06.	9
27048876	2016	Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population.	4
29623515	2018	DNA methylation-based subclassification of psoriasis in the Chinese Han population.	1
20213803	2010	Deletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis.	0

Citation

Dessen P

LCE3C (late cornified envelope 3C)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/65200/lce3c