Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

LCLAT1 (lysocardiolipin acyltransferase 1)

Identity

Alias (NCBI)1AGPAT8
AGPAT8
ALCAT1
HSRG1849
LYCAT
UNQ1849
HGNC (Hugo) LCLAT1
HGNC Alias symbFLJ37965
ALCAT1
AGPAT8
HGNC Previous nameLYCAT
HGNC Previous namelysocardiolipin acyltransferase
LocusID (NCBI) 253558
Atlas_Id 54419
Location 2p23.1  [Link to chromosome band 2p23]
Location_base_pair Starts at 30447246 and ends at 30644225 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GRHPR (9p13.2)::LCLAT1 (2p23.1)LCLAT1 (2p23.1)::EPHA3 (3p11.1)LCLAT1 (2p23.1)::ERBB4 (2q34)
TMEM55A (8q21.3)::LCLAT1 (2p23.1)TMPRSS11B (4q13.2)::LCLAT1 (2p23.1)LCLAT1 2p23.1::EPHA3 3p11.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LCLAT1   26756
Cards
Entrez_Gene (NCBI)LCLAT1    lysocardiolipin acyltransferase 1
Aliases1AGPAT8; AGPAT8; ALCAT1; HSRG1849; 
LYCAT; UNQ1849
GeneCards (Weizmann)LCLAT1
Ensembl hg19 (Hinxton)ENSG00000172954 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172954 [Gene_View]  ENSG00000172954 [Sequence]  chr2:30447246-30644225 [Contig_View]  LCLAT1 [Vega]
ICGC DataPortalENSG00000172954
TCGA cBioPortalLCLAT1
AceView (NCBI)LCLAT1
Genatlas (Paris)LCLAT1
SOURCE (Princeton)LCLAT1
Genetics Home Reference (NIH)LCLAT1
Genomic and cartography
GoldenPath hg38 (UCSC)LCLAT1  -     chr2:30447246-30644225 +  2p23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LCLAT1  -     2p23.1   [Description]    (hg19-Feb_2009)
GoldenPathLCLAT1 - 2p23.1 [CytoView hg19]  LCLAT1 - 2p23.1 [CytoView hg38]
ImmunoBaseENSG00000172954
Genome Data Viewer NCBILCLAT1 [Mapview hg19]  
OMIM614241   
Gene and transcription
Genbank (Entrez)AA455668 AK023269 AK095284 AK296965 AK297262
RefSeq transcript (Entrez)NM_001002257 NM_001304445 NM_001304446 NM_182551
Consensus coding sequences : CCDS (NCBI)LCLAT1
Gene ExpressionLCLAT1 [ NCBI-GEO ]   LCLAT1 [ EBI - ARRAY_EXPRESS ]   LCLAT1 [ SEEK ]   LCLAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)LCLAT1 [ Firebrowse - Broad ]
GenevisibleExpression of LCLAT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)253558
GTEX Portal (Tissue expression)LCLAT1
Human Protein AtlasENSG00000172954-LCLAT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UWP7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UWP7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UWP7
PhosPhoSitePlusQ6UWP7
Domains : Interpro (EBI)Acyltransf_C    Plipid/glycerol_acylTrfase   
Domain families : Pfam (Sanger)Acyltransf_C (PF16076)    Acyltransferase (PF01553)   
Domain families : Pfam (NCBI)pfam16076    pfam01553   
Domain families : Smart (EMBL)PlsC (SM00563)  
Conserved Domain (NCBI)LCLAT1
SuperfamilyQ6UWP7
AlphaFold pdb e-kbQ6UWP7   
Human Protein Atlas [tissue]ENSG00000172954-LCLAT1 [tissue]
HPRD17458
Protein Interaction databases
DIP (DOE-UCLA)Q6UWP7
IntAct (EBI)Q6UWP7
BioGRIDLCLAT1
STRING (EMBL)LCLAT1
ZODIACLCLAT1
Ontologies - Pathways
QuickGOQ6UWP7
Ontology : AmiGO1-acylglycerol-3-phosphate O-acyltransferase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  phosphatidic acid biosynthetic process  multicellular organism development  endomembrane system  membrane  integral component of membrane  CDP-diacylglycerol biosynthetic process  acyltransferase activity  cardiolipin acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  
Ontology : EGO-EBI1-acylglycerol-3-phosphate O-acyltransferase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  phosphatidic acid biosynthetic process  multicellular organism development  endomembrane system  membrane  integral component of membrane  CDP-diacylglycerol biosynthetic process  acyltransferase activity  cardiolipin acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  
Pathways : KEGGGlycerolipid metabolism    Glycerophospholipid metabolism   
NDEx NetworkLCLAT1
Atlas of Cancer Signalling NetworkLCLAT1
Wikipedia pathwaysLCLAT1
Orthology - Evolution
OrthoDB253558
GeneTree (enSembl)ENSG00000172954
Phylogenetic Trees/Animal Genes : TreeFamLCLAT1
Homologs : HomoloGeneLCLAT1
Homology/Alignments : Family Browser (UCSC)LCLAT1
Gene fusions - Rearrangements
Fusion : MitelmanLCLAT1::EPHA3 [2p23.1/3p11.1]  
Fusion : MitelmanLCLAT1::ERBB4 [2p23.1/2q34]  
Fusion : MitelmanTMEM55A::LCLAT1 [8q21.3/2p23.1]  
Fusion : QuiverLCLAT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLCLAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LCLAT1
dbVarLCLAT1
ClinVarLCLAT1
MonarchLCLAT1
1000_GenomesLCLAT1 
Exome Variant ServerLCLAT1
GNOMAD BrowserENSG00000172954
Varsome BrowserLCLAT1
ACMGLCLAT1 variants
VarityQ6UWP7
Genomic Variants (DGV)LCLAT1 [DGVbeta]
DECIPHERLCLAT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLCLAT1 
Mutations
ICGC Data PortalLCLAT1 
TCGA Data PortalLCLAT1 
Broad Tumor PortalLCLAT1
OASIS PortalLCLAT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLCLAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLCLAT1
Mutations and Diseases : HGMDLCLAT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLCLAT1
DgiDB (Drug Gene Interaction Database)LCLAT1
DoCM (Curated mutations)LCLAT1
CIViC (Clinical Interpretations of Variants in Cancer)LCLAT1
Cancer3DLCLAT1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614241   
Orphanet
DisGeNETLCLAT1
MedgenLCLAT1
Genetic Testing Registry LCLAT1
NextProtQ6UWP7 [Medical]
GENETestsLCLAT1
Target ValidationLCLAT1
Huge Navigator LCLAT1 [HugePedia]
ClinGenLCLAT1
Clinical trials, drugs, therapy
MyCancerGenomeLCLAT1
Protein Interactions : CTDLCLAT1
Pharm GKB GenePA164722072
PharosQ6UWP7
Clinical trialLCLAT1
Miscellaneous
canSAR (ICR)LCLAT1
HarmonizomeLCLAT1
ARCHS4LCLAT1
DataMed IndexLCLAT1
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLCLAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Jan 16 18:17:26 CET 2022

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.