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LCLAT1 (lysocardiolipin acyltransferase 1)

Identity

Alias_namesLYCAT
lysocardiolipin acyltransferase
Alias_symbol (synonym)FLJ37965
ALCAT1
AGPAT8
Other alias1AGPAT8
HSRG1849
UNQ1849
HGNC (Hugo) LCLAT1
LocusID (NCBI) 253558
Atlas_Id 54419
Location 2p23.1  [Link to chromosome band 2p23]
Location_base_pair Starts at 30670092 and ends at 30867091 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GRHPR (9p13.2) / LCLAT1 (2p23.1)LCLAT1 (2p23.1) / EPHA3 (3p11.1)LCLAT1 (2p23.1) / ERBB4 (2q34)
TMEM55A (8q21.3) / LCLAT1 (2p23.1)TMPRSS11B (4q13.2) / LCLAT1 (2p23.1)LCLAT1 2p23.1 / EPHA3 3p11.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LCLAT1   26756
Cards
Entrez_Gene (NCBI)LCLAT1  253558  lysocardiolipin acyltransferase 1
Aliases1AGPAT8; AGPAT8; ALCAT1; HSRG1849; 
LYCAT; UNQ1849
GeneCards (Weizmann)LCLAT1
Ensembl hg19 (Hinxton)ENSG00000172954 [Gene_View]  chr2:30670092-30867091 [Contig_View]  LCLAT1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000172954 [Gene_View]  chr2:30670092-30867091 [Contig_View]  LCLAT1 [Vega]
ICGC DataPortalENSG00000172954
TCGA cBioPortalLCLAT1
AceView (NCBI)LCLAT1
Genatlas (Paris)LCLAT1
WikiGenes253558
SOURCE (Princeton)LCLAT1
Genetics Home Reference (NIH)LCLAT1
Genomic and cartography
GoldenPath hg19 (UCSC)LCLAT1  -     chr2:30670092-30867091 +  2p23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LCLAT1  -     2p23.1   [Description]    (hg38-Dec_2013)
EnsemblLCLAT1 - 2p23.1 [CytoView hg19]  LCLAT1 - 2p23.1 [CytoView hg38]
Mapping of homologs : NCBILCLAT1 [Mapview hg19]  LCLAT1 [Mapview hg38]
OMIM614241   
Gene and transcription
Genbank (Entrez)AA455668 AK023269 AK095284 AK296965 AK297262
RefSeq transcript (Entrez)NM_001002257 NM_001304445 NM_001304446 NM_182551
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)LCLAT1
Cluster EST : UnigeneHs.662770 [ NCBI ]
CGAP (NCI)Hs.662770
Alternative Splicing GalleryENSG00000172954
Gene ExpressionLCLAT1 [ NCBI-GEO ]   LCLAT1 [ EBI - ARRAY_EXPRESS ]   LCLAT1 [ SEEK ]   LCLAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)LCLAT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)253558
GTEX Portal (Tissue expression)LCLAT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UWP7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UWP7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UWP7
Splice isoforms : SwissVarQ6UWP7
Catalytic activity : Enzyme2.3.1.- [ Enzyme-Expasy ]   2.3.1.-2.3.1.- [ IntEnz-EBI ]   2.3.1.- [ BRENDA ]   2.3.1.- [ KEGG ]   
PhosPhoSitePlusQ6UWP7
Domains : Interpro (EBI)Acyltransf_C    Plipid/glycerol_acylTrfase   
Domain families : Pfam (Sanger)Acyltransf_C (PF16076)    Acyltransferase (PF01553)   
Domain families : Pfam (NCBI)pfam16076    pfam01553   
Domain families : Smart (EMBL)PlsC (SM00563)  
Conserved Domain (NCBI)LCLAT1
DMDM Disease mutations253558
Blocks (Seattle)LCLAT1
SuperfamilyQ6UWP7
Human Protein AtlasENSG00000172954
Peptide AtlasQ6UWP7
HPRD17458
IPIIPI00419643   IPI00166225   IPI00910254   IPI00456786   IPI00945829   IPI00945290   IPI00946883   IPI00945617   IPI00946529   IPI00946360   IPI00945450   IPI00945977   
Protein Interaction databases
DIP (DOE-UCLA)Q6UWP7
IntAct (EBI)Q6UWP7
FunCoupENSG00000172954
BioGRIDLCLAT1
STRING (EMBL)LCLAT1
ZODIACLCLAT1
Ontologies - Pathways
QuickGOQ6UWP7
Ontology : AmiGO1-acylglycerol-3-phosphate O-acyltransferase activity  protein binding  endoplasmic reticulum membrane  phosphatidic acid biosynthetic process  multicellular organism development  O-acyltransferase activity  membrane  integral component of membrane  CDP-diacylglycerol biosynthetic process  triglyceride biosynthetic process  cardiolipin acyl-chain remodeling  
Ontology : EGO-EBI1-acylglycerol-3-phosphate O-acyltransferase activity  protein binding  endoplasmic reticulum membrane  phosphatidic acid biosynthetic process  multicellular organism development  O-acyltransferase activity  membrane  integral component of membrane  CDP-diacylglycerol biosynthetic process  triglyceride biosynthetic process  cardiolipin acyl-chain remodeling  
Pathways : KEGGGlycerolipid metabolism    Glycerophospholipid metabolism   
NDEx NetworkLCLAT1
Atlas of Cancer Signalling NetworkLCLAT1
Wikipedia pathwaysLCLAT1
Orthology - Evolution
OrthoDB253558
GeneTree (enSembl)ENSG00000172954
Phylogenetic Trees/Animal Genes : TreeFamLCLAT1
HOVERGENQ6UWP7
HOGENOMQ6UWP7
Homologs : HomoloGeneLCLAT1
Homology/Alignments : Family Browser (UCSC)LCLAT1
Gene fusions - Rearrangements
Fusion : MitelmanLCLAT1/EPHA3 [2p23.1/3p11.1]  
Fusion : MitelmanLCLAT1/ERBB4 [2p23.1/2q34]  [t(2;2)(p23;q34)]  
Fusion : MitelmanTMEM55A/LCLAT1 [8q21.3/2p23.1]  [t(2;8)(p23;q21)]  
Fusion: TCGALCLAT1 2p23.1 EPHA3 3p11.1 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLCLAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LCLAT1
dbVarLCLAT1
ClinVarLCLAT1
1000_GenomesLCLAT1 
Exome Variant ServerLCLAT1
ExAC (Exome Aggregation Consortium)LCLAT1 (select the gene name)
Genetic variants : HAPMAP253558
Genomic Variants (DGV)LCLAT1 [DGVbeta]
DECIPHER (Syndromes)2:30670092-30867091  ENSG00000172954
CONAN: Copy Number AnalysisLCLAT1 
Mutations
ICGC Data PortalLCLAT1 
TCGA Data PortalLCLAT1 
Broad Tumor PortalLCLAT1
OASIS PortalLCLAT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLCLAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLCLAT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LCLAT1
DgiDB (Drug Gene Interaction Database)LCLAT1
DoCM (Curated mutations)LCLAT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LCLAT1 (select a term)
intoGenLCLAT1
Cancer3DLCLAT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614241   
Orphanet
MedgenLCLAT1
Genetic Testing Registry LCLAT1
NextProtQ6UWP7 [Medical]
TSGene253558
GENETestsLCLAT1
Huge Navigator LCLAT1 [HugePedia]
snp3D : Map Gene to Disease253558
BioCentury BCIQLCLAT1
ClinGenLCLAT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD253558
Chemical/Pharm GKB GenePA164722072
Clinical trialLCLAT1
Miscellaneous
canSAR (ICR)LCLAT1 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLCLAT1
EVEXLCLAT1
GoPubMedLCLAT1
iHOPLCLAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:12:33 CET 2017

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