LCMT1 (leucine carboxyl methyltransferase 1)

2014-08-01  

Identity

HGNC
LCMT1
LOCATION
16p12.1
LOCUSID
51451
ALIAS
CGI-68,LCMT,PPMT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51451
MIM: 610286
HGNC: 17557
Ensembl: ENSG00000205629

Variants:

dbSNP: 51451
ClinVar: 51451
TCGA: ENSG00000205629
COSMIC: LCMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205629ENST00000380962H7BYF0
ENSG00000205629ENST00000380966Q9UIC8
ENSG00000205629ENST00000399069Q9UIC8
ENSG00000205629ENST00000564011H3BUP7
ENSG00000205629ENST00000570981I3L2Q8
ENSG00000205629ENST00000572761I3L2E3
ENSG00000205629ENST00000575396I3L537
ENSG00000205629ENST00000576625I3L4A2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
224436832013The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity.64
212921652011The structural basis for tight control of PP2A methylation and function by LCMT-1.42
177240242007Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells.20
278109032017NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability.17
227325522012Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.9
239436182013Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells.9
258396652015A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size.5
212060582011The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A.4

Citation

Dessen P

LCMT1 (leucine carboxyl methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54420/lcmt1