LCMT2 (leucine carboxyl methyltransferase 2)

2003-12-01  

Identity

HGNC
LOCATION
15q15.3
LOCUSID
ALIAS
PPM2,TYW4

Other Information

Locus ID:

NCBI: 9836
MIM: 611246
HGNC: 17558
Ensembl: ENSG00000168806

Variants:

dbSNP: 9836
ClinVar: 9836
TCGA: ENSG00000168806
COSMIC: LCMT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168806ENST00000305641O60294
ENSG00000168806ENST00000567039H3BU01

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315
Synthesis of wybutosine at G37 of tRNA(Phe)REACTOMER-HSA-6782861

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192870062009Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.17
124858772002Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells.14
222532322012KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A.13
168303652006Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor.8
158139172005Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders.5
170269582006p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1.5

Citation

Dessen P

LCMT2 (leucine carboxyl methyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41132/lcmt2