LCMT2 (leucine carboxyl methyltransferase 2)

2003-12-01  

Identity

HGNC
LCMT2
LOCATION
15q15.3
LOCUSID
9836
ALIAS
PPM2,TYW4

Other Information

Locus ID:

NCBI: 9836
MIM: 611246
HGNC: 17558
Ensembl: ENSG00000168806

Variants:

dbSNP: 9836
ClinVar: 9836
TCGA: ENSG00000168806
COSMIC: LCMT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168806ENST00000305641O60294
ENSG00000168806ENST00000567039H3BU01

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315
Synthesis of wybutosine at G37 of tRNA(Phe)REACTOMER-HSA-6782861

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
222532322012KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A.18
222532322012KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A.18
192870062009Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.20
192870062009Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.20

Citation

Dessen P

LCMT2 (leucine carboxyl methyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41132/lcmt2