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LCP2 (lymphocyte cytosolic protein 2)

Identity

Alias (NCBI)IMD81
SLP-76
SLP76
HGNC (Hugo) LCP2
HGNC Alias symbSLP-76
HGNC Alias name76 kDa tyrosine phosphoprotein
 SH2 domain-containing leukocyte protein of 76kD
HGNC Previous nameSLP76
HGNC Previous namelymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LocusID (NCBI) 3937
Atlas_Id 45540
Location 5q35.1  [Link to chromosome band 5q35]
Location_base_pair Starts at 170246233 and ends at 170297777 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SGCD (5q33.3)::LCP2 (5q35.1)SGCD 5q33.3::LCP2 5q35.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)LCP2   6529
Cards
Entrez_Gene (NCBI)LCP2    lymphocyte cytosolic protein 2
AliasesIMD81; SLP-76; SLP76
GeneCards (Weizmann)LCP2
Ensembl hg19 (Hinxton)ENSG00000043462 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000043462 [Gene_View]  ENSG00000043462 [Sequence]  chr5:170246233-170297777 [Contig_View]  LCP2 [Vega]
ICGC DataPortalENSG00000043462
TCGA cBioPortalLCP2
AceView (NCBI)LCP2
Genatlas (Paris)LCP2
SOURCE (Princeton)LCP2
Genetics Home Reference (NIH)LCP2
Genomic and cartography
GoldenPath hg38 (UCSC)LCP2  -     chr5:170246233-170297777 -  5q35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LCP2  -     5q35.1   [Description]    (hg19-Feb_2009)
GoldenPathLCP2 - 5q35.1 [CytoView hg19]  LCP2 - 5q35.1 [CytoView hg38]
ImmunoBaseENSG00000043462
Genome Data Viewer NCBILCP2 [Mapview hg19]  
OMIM601603   619374   
Gene and transcription
Genbank (Entrez)AF086367 AK122637 AK292890 AK296098 AK300000
RefSeq transcript (Entrez)NM_005565
Consensus coding sequences : CCDS (NCBI)LCP2
Gene ExpressionLCP2 [ NCBI-GEO ]   LCP2 [ EBI - ARRAY_EXPRESS ]   LCP2 [ SEEK ]   LCP2 [ MEM ]
Gene Expression Viewer (FireBrowse)LCP2 [ Firebrowse - Broad ]
GenevisibleExpression of LCP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3937
GTEX Portal (Tissue expression)LCP2
Human Protein AtlasENSG00000043462-LCP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13094   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13094  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13094
PhosPhoSitePlusQ13094
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)SAM    SAM/pointed_sf    SH2    SH2_dom_sf   
Domain families : Pfam (Sanger)SAM_2 (PF07647)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam07647    pfam00017   
Domain families : Smart (EMBL)SAM (SM00454)  SH2 (SM00252)  
Conserved Domain (NCBI)LCP2
PDB (RSDB)1H3H    1YWO    2EAP    2ROR   
PDB Europe1H3H    1YWO    2EAP    2ROR   
PDB (PDBSum)1H3H    1YWO    2EAP    2ROR   
PDB (IMB)1H3H    1YWO    2EAP    2ROR   
Structural Biology KnowledgeBase1H3H    1YWO    2EAP    2ROR   
SCOP (Structural Classification of Proteins)1H3H    1YWO    2EAP    2ROR   
CATH (Classification of proteins structures)1H3H    1YWO    2EAP    2ROR   
SuperfamilyQ13094
AlphaFold pdb e-kbQ13094   
Human Protein Atlas [tissue]ENSG00000043462-LCP2 [tissue]
HPRD03362
Protein Interaction databases
DIP (DOE-UCLA)Q13094
IntAct (EBI)Q13094
BioGRIDLCP2
STRING (EMBL)LCP2
ZODIACLCP2
Ontologies - Pathways
QuickGOQ13094
Ontology : AmiGOprotein binding  cytosol  cytosol  cell-cell junction  immune response  transmembrane receptor protein tyrosine kinase signaling pathway  intracellular signal transduction  TCR signalosome  plasma membrane raft  mast cell activation  positive regulation of protein kinase activity  T cell receptor signaling pathway  
Ontology : EGO-EBIprotein binding  cytosol  cytosol  cell-cell junction  immune response  transmembrane receptor protein tyrosine kinase signaling pathway  intracellular signal transduction  TCR signalosome  plasma membrane raft  mast cell activation  positive regulation of protein kinase activity  T cell receptor signaling pathway  
Pathways : KEGGKEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY    KEGG_T_CELL_RECEPTOR_SIGNALING    KEGG_FC_EPSILON_RI_SIGNALING   
NDEx NetworkLCP2
Atlas of Cancer Signalling NetworkLCP2
Wikipedia pathwaysLCP2
Orthology - Evolution
OrthoDB3937
GeneTree (enSembl)ENSG00000043462
Phylogenetic Trees/Animal Genes : TreeFamLCP2
Homologs : HomoloGeneLCP2
Homology/Alignments : Family Browser (UCSC)LCP2
Gene fusions - Rearrangements
Fusion : MitelmanSGCD::LCP2 [5q33.3/5q35.1]  
Fusion : QuiverLCP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLCP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LCP2
dbVarLCP2
ClinVarLCP2
MonarchLCP2
1000_GenomesLCP2 
Exome Variant ServerLCP2
GNOMAD BrowserENSG00000043462
Varsome BrowserLCP2
ACMGLCP2 variants
VarityQ13094
Genomic Variants (DGV)LCP2 [DGVbeta]
DECIPHERLCP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLCP2 
Mutations
ICGC Data PortalLCP2 
TCGA Data PortalLCP2 
Broad Tumor PortalLCP2
OASIS PortalLCP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLCP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLCP2
Mutations and Diseases : HGMDLCP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLCP2
DgiDB (Drug Gene Interaction Database)LCP2
DoCM (Curated mutations)LCP2
CIViC (Clinical Interpretations of Variants in Cancer)LCP2
Cancer3DLCP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601603    619374   
Orphanet
DisGeNETLCP2
MedgenLCP2
Genetic Testing Registry LCP2
NextProtQ13094 [Medical]
GENETestsLCP2
Target ValidationLCP2
Huge Navigator LCP2 [HugePedia]
ClinGenLCP2
Clinical trials, drugs, therapy
MyCancerGenomeLCP2
Protein Interactions : CTDLCP2
Pharm GKB GenePA30313
PharosQ13094
Clinical trialLCP2
Miscellaneous
canSAR (ICR)LCP2
HarmonizomeLCP2
ARCHS4LCP2
DataMed IndexLCP2
Probes
Litterature
PubMed169 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLCP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:40:32 CET 2022
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